| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiological Reviews, Vol. 79, No. 4, October 1999, pp. 1157-1191
Copyright ©1999 by the American Physiological Society
Physiologisches Institut, Universität München, München, Germany
Horster, Michael F.,
Gerald S. Braun, and
Stephan M. Huber.
Embryonic Renal Epithelia: Induction, Nephrogenesis, and Cell
Differentiation. J. Neurophysiol. 79: 1157-1191, 1999. Embryonic metanephroi, differentiating into the adult kidney,
have come to be a generally accepted model system for organogenesis. Nephrogenesis implies a highly controlled series of morphogenetic and
differentiation events that starts with reciprocal inductive interactions between two different primordial tissues and leads, in one
of two mainstream processes, to the formation of mesenchymal condensations and aggregates. These go through the intricate process of
mesenchyme-to-epithelium transition by which epithelial cell polarization is initiated, and they continue to differentiate into the
highly specialized epithelial cell populations of the nephron. Each
step along the developmental metanephrogenic pathway is initiated and
organized by signaling molecules that are locally secreted polypeptides
encoded by different gene families and regulated by transcription
factors. Nephrogenesis proceeds from the deep to the outer cortex, and
it is directed by a second, entirely different developmental process,
the ductal branching of the ureteric bud-derived collecting tubule.
Both systems, the nephrogenic (mesenchymal) and the ductogenic
(ureteric), undergo a repeat series of inductive signaling that serves
to organize the architecture and differentiated cell functions in a
cascade of developmental gene programs. The aim of this review is to
present a coherent picture of principles and mechanisms in embryonic
renal epithelia.
This article has been cited by other articles:
|
|
 |
|
  J. Achenbach, M. Mengel, I. Tossidou, I. Peters, J.-K. Park, M. Haubitz, J. H. Ehrich, H. Haller, and M. Schiffer Parietal epithelia cells in the urine as a marker of disease activity in glomerular diseases Nephrol. Dial. Transplant., May 5, 2008; (2008) gfn235v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, Y. S. Kang, C. Dai, L. P. Kiss, X. Wen, and Y. Liu Epithelial-to-Mesenchymal Transition Is a Potential Pathway Leading to Podocyte Dysfunction and Proteinuria Am. J. Pathol., February 1, 2008; 172(2): 299 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, J. Yang, J.-H. Luo, S. Dedhar, and Y. Liu Tubular Epithelial Cell Dedifferentiation Is Driven by the Helix-Loop-Helix Transcriptional Inhibitor Id1 J. Am. Soc. Nephrol., February 1, 2007; 18(2): 449 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Marshall, M. R. Dilworth, M. Clancy, C. A. Bravery, and N. Ashton Renal: Increasing renal mass improves survival in anephric rats following metanephros transplantation Exp Physiol, January 1, 2007; 92(1): 263 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Allory, F. Commo, L. Boccon-Gibod, M. Sibony, P. Callard, P. Ronco, and H. Debiec Sulfated HNK-1 Epitope in Developing and Mature Kidney: A New Marker for Thin Ascending Loop of Henle and Tubular Injury in Acute Tubular Necrosis J. Histochem. Cytochem., May 1, 2006; 54(5): 575 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Sheng, G. Wang, D. P. La Pierre, J. Wen, Z. Deng, C.-K. A. Wong, D. Y. Lee, and B. B. Yang Versican Mediates Mesenchymal-Epithelial Transition Mol. Biol. Cell, April 1, 2006; 17(4): 2009 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zeisberg, A. A. Shah, and R. Kalluri Bone Morphogenic Protein-7 Induces Mesenchymal to Epithelial Transition in Adult Renal Fibroblasts and Facilitates Regeneration of Injured Kidney J. Biol. Chem., March 4, 2005; 280(9): 8094 - 8100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-S. Lee, A. O. Vortmeyer, I. A. Lubensky, T. W.A. Vogel, B. Ikejiri, S. Ferlicot, G. Benoit, S. Giraud, E. H. Oldfield, W. M. Linehan, et al. Coexpression of Erythropoietin and Erythropoietin Receptor in Von Hippel-Lindau Disease-Associated Renal Cysts and Renal Cell Carcinoma Clin. Cancer Res., February 1, 2005; 11(3): 1059 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Anglesio, V. Evdokimova, N. Melnyk, L. Zhang, C. V. Fernandez, P. E. Grundy, S. Leach, M. A. Marra, A. R. Brooks-Wilson, J. Penninger, et al. Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney Hum. Mol. Genet., September 15, 2004; 13(18): 2061 - 2074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Challen, G. Martinez, M. J. Davis, D. F. Taylor, M. Crowe, R. D. Teasdale, S. M. Grimmond, and M. H. Little Identifying the Molecular Phenotype of Renal Progenitor Cells J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2344 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Roitbak, C. J. Ward, P. C. Harris, R. Bacallao, S. A. Ness, and A. Wandinger-Ness A Polycystin-1 Multiprotein Complex Is Disrupted in Polycystic Kidney Disease Cells Mol. Biol. Cell, March 1, 2004; 15(3): 1334 - 1346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu Epithelial to Mesenchymal Transition in Renal Fibrogenesis: Pathologic Significance, Molecular Mechanism, and Therapeutic Intervention J. Am. Soc. Nephrol., January 1, 2004; 15(1): 1 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dai, J. Yang, and Y. Liu Transforming Growth Factor-beta 1 Potentiates Renal Tubular Epithelial Cell Death by a Mechanism Independent of Smad Signaling J. Biol. Chem., March 28, 2003; 278(14): 12537 - 12545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Pavenstadt, W. Kriz, and M. Kretzler Cell Biology of the Glomerular Podocyte Physiol Rev, January 1, 2003; 83(1): 253 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Douglas-Denton, K. M. Moritz, J. F. Bertram, and E. M. Wintour Compensatory Renal Growth after Unilateral Nephrectomy in the Ovine Fetus J. Am. Soc. Nephrol., February 1, 2002; 13(2): 406 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yokoyama, J. Yasuda, H. Okamoto, and Y. Iwakura Pathological changes of renal epithelial cells in mice transgenic for the TT virus ORF1 gene J. Gen. Virol., January 1, 2002; 83(1): 141 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yang and Y. Liu Blockage of Tubular Epithelial to Myofibroblast Transition by Hepatocyte Growth Factor Prevents Renal Interstitial Fibrosis J. Am. Soc. Nephrol., January 1, 2002; 13(1): 96 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yang and Y. Liu Dissection of Key Events in Tubular Epithelial to Myofibroblast Transition and Its Implications in Renal Interstitial Fibrosis Am. J. Pathol., October 1, 2001; 159(4): 1465 - 1475. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. P. Wallace, L. A. Rome, L. P. Sullivan, and J. J. Grantham cAMP-dependent fluid secretion in rat inner medullary collecting ducts Am J Physiol Renal Physiol, June 1, 2001; 280(6): F1019 - F1029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Horster Embryonic epithelial membrane transporters Am J Physiol Renal Physiol, December 1, 2000; 279(6): F982 - F996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yang, Y. Tian, J. Wada, N. Kashihara, E. Wallner, D. Peterson, and Y. S. Kanwar Expression characteristics and relevance of sodium glucose cotransporter-1 in mammalian renal tubulogenesis Am J Physiol Renal Physiol, October 1, 2000; 279(4): F765 - F777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Huber, G. S. Braun, S. Segerer, R. W. Veh, and M. F. Horster Metanephrogenic mesenchyme-to-epithelium transition induces profound expression changes of ion channels Am J Physiol Renal Physiol, July 1, 2000; 279(1): F65 - F76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Kanwar, Q. Yang, Y. Tian, S. Lin, J. Wada, S. Chugh, and S. K. Srivastava Relevance of renal-specific oxidoreductase in tubulogenesis during mammalian nephron development Am J Physiol Renal Physiol, April 1, 2002; 282(4): F752 - F762. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
