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Physiological Reviews, Vol. 79, No. 4, October 1999, pp. 1127-1155
Copyright ©1999 by the American Physiological Society
Department of Biomedical Sciences, University of Padova, and Consiglio Nazionale delle Ricerche Center for the Study of Biomembranes, Padova, Italy
Bernardi, Paolo
Mitochondrial Transport of Cations: Channels, Exchangers, and
Permeability Transition. J. Neurophysiol. 79: 1127-1155, 1999. This review provides a selective history of how
studies of mitochondrial cation transport (K+,
Na+, Ca2+) developed in relation to the major
themes of research in bioenergetics. It then covers in some detail
specific transport pathways for these cations, and it introduces and
discusses open problems about their nature and physiological function,
particularly in relation to volume regulation and Ca2+
homeostasis. The review should provide the basic elements needed to
understand both earlier mitochondrial literature and current problems
associated with mitochondrial transport of cations and hopefully will
foster new interest in the molecular definition of mitochondrial cation
channels and exchangers as well as their roles in cell physiology.
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