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Physiological Reviews, Vol. 79, No. 2, April 1999, pp. 387-423
Copyright ©1999 by the American Physiological Society
Department of Medical Physiology, Microcirculation Research Institute, Texas A&M University, College Station, Texas; and Microvascular Biology Group, Department of Human Biology and Movement Science, RMIT University, Bundoora, Victoria, Australia
Davis, Michael J. and
Michael A. Hill.
The vascular myogenic response refers to the acute
reaction of a blood vessel to a change in transmural pressure. This
response is critically important for the development of resting
vascular tone, upon which other control mechanisms exert vasodilator
and vasoconstrictor influences. The purpose of this review is to
summarize and synthesize information regarding the cellular
mechanism(s) underlying the myogenic response in blood vessels, with
particular emphasis on arterioles. When necessary, experiments
performed on larger blood vessels, visceral smooth muscle, and even
striated muscle are cited. Mechanical aspects of myogenic behavior are discussed first, followed by electromechanical coupling mechanisms. Next, mechanotransduction by membrane-bound enzymes and involvement of second messengers, including calcium, are discussed. After this, the
roles of the extracellular matrix, integrins, and the smooth muscle
cytoskeleton are reviewed, with emphasis on short-term signaling
mechanisms. Finally, suggestions are offered for possible future studies.
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D. Xiao, J. N. Buchholz, and L. Zhang Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2337 - H2343. [Abstract] [Full Text] [PDF] |
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R. Loutzenhiser, K. Griffin, G. Williamson, and A. Bidani Renal autoregulation: new perspectives regarding the protective and regulatory roles of the underlying mechanisms Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1153 - R1167. [Abstract] [Full Text] [PDF] |
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A. J. McNeish, S. L. Sandow, C. B. Neylon, M. X. Chen, K. A. Dora, and C. J. Garland Evidence for Involvement of Both IKCa and SKCa Channels in Hyperpolarizing Responses of the Rat Middle Cerebral Artery Stroke, May 1, 2006; 37(5): 1277 - 1282. [Abstract] [Full Text] [PDF] |
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B. Lopez, R. P. Ryan, C. Moreno, A. Sarkis, J. Lazar, A. P. Provoost, H. J. Jacob, and R. J. Roman Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1213 - F1221. [Abstract] [Full Text] [PDF] |
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P. S. Clifford, H. A. Kluess, J. J. Hamann, J. B. Buckwalter, and J. L. Jasperse Mechanical compression elicits vasodilatation in rat skeletal muscle feed arteries J. Physiol., April 15, 2006; 572(2): 561 - 567. [Abstract] [Full Text] [PDF] |
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U. Yokoyama, S. Minamisawa, S. Adachi-Akahane, T. Akaike, I. Naguro, K. Funakoshi, M. Iwamoto, M. Nakagome, N. Uemura, H. Hori, et al. Multiple transcripts of Ca2+ channel {alpha}1-subunits and a novel spliced variant of the {alpha}1C-subunit in rat ductus arteriosus Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1660 - H1670. [Abstract] [Full Text] [PDF] |
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R. L. Armentano, J. G. Barra, D. B. Santana, F. M. Pessana, S. Graf, D. Craiem, L. M. Brandani, H. P. Baglivo, and R. A. Sanchez Smart Damping Modulation of Carotid Wall Energetics in Human Hypertension: Effects of Angiotensin-Converting Enzyme Inhibition Hypertension, March 1, 2006; 47(3): 384 - 390. [Abstract] [Full Text] [PDF] |
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R. H. P. Hilgers and R. C. Webb Molecular Aspects of Arterial Smooth Muscle Contraction: Focus on Rho Experimental Biology and Medicine, December 1, 2005; 230(11): 829 - 835. [Abstract] [Full Text] [PDF] |
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L. Wang, P. Chitano, and T. M. Murphy Length oscillation induces force potentiation in infant guinea pig airway smooth muscle Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L909 - L915. [Abstract] [Full Text] [PDF] |
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K. Okazaki, Q. Fu, E. R. Martini, R. Shook, C. Conner, R. Zhang, C. G. Crandall, and B. D. Levine Vasoconstriction during venous congestion: effects of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1354 - R1359. [Abstract] [Full Text] [PDF] |
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K. A. Dora Does arterial myogenic tone determine blood flow distribution in vivo? Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1323 - H1325. [Full Text] [PDF] |
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N. L. Jernigan and H. A. Drummond Vascular ENaC proteins are required for renal myogenic constriction Am J Physiol Renal Physiol, October 1, 2005; 289(4): F891 - F901. [Abstract] [Full Text] [PDF] |
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N. Kotecha and M. A. Hill Myogenic contraction in rat skeletal muscle arterioles: smooth muscle membrane potential and Ca2+ signaling Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1326 - H1334. [Abstract] [Full Text] [PDF] |
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A. Huang, D. Sun, C. Yan, J. R. Falck, and G. Kaley Contribution of 20-HETE to Augmented Myogenic Constriction in Coronary Arteries of Endothelial NO Synthase Knockout Mice Hypertension, September 1, 2005; 46(3): 607 - 613. [Abstract] [Full Text] [PDF] |
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Z. Bagi, N. Erdei, A. Toth, W. Li, T. H. Hintze, A. Koller, and G. Kaley Type 2 Diabetic Mice Have Increased Arteriolar Tone and Blood Pressure: Enhanced Release of COX-2-Derived Constrictor Prostaglandins Arterioscler Thromb Vasc Biol, August 1, 2005; 25(8): 1610 - 1616. [Abstract] [Full Text] [PDF] |
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D. G. Hemmings, S. J. Williams, and S. T. Davidge Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H674 - H682. [Abstract] [Full Text] [PDF] |
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L. A. Martinez-Lemus, T. Crow, M. J. Davis, and G. A. Meininger {alpha}v{beta}3- and {alpha}5{beta}1-integrin blockade inhibits myogenic constriction of skeletal muscle resistance arterioles Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H322 - H329. [Abstract] [Full Text] [PDF] |
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N. I. Gokina, K. M. Park, K. McElroy-Yaggy, and G. Osol Effects of Rho kinase inhibition on cerebral artery myogenic tone and reactivity J Appl Physiol, May 1, 2005; 98(5): 1940 - 1948. [Abstract] [Full Text] [PDF] |
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D. G. Hemmings, S. Veerareddy, P. N. Baker, and S. T. Davidge Increased Myogenic Responses in Uterine but not Mesenteric Arteries from Pregnant Offspring of Diet-Restricted Rat Dams Biol Reprod, April 1, 2005; 72(4): 997 - 1003. [Abstract] [Full Text] [PDF] |
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J. Ohanian, K. M. Gatfield, D. T. Ward, and V. Ohanian Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1756 - H1762. [Abstract] [Full Text] [PDF] |
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