Physiol Rev Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 79: 263-323, 1999;
0031-9333/99 $15.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCracken, J. A.
Right arrow Articles by Lamsa, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCracken, J. A.
Right arrow Articles by Lamsa, J. C.

Physiological Reviews, Vol. 79, No. 2, April 1999, pp. 263-323
Copyright ©1999 by the American Physiological Society

Luteolysis: A Neuroendocrine-Mediated Event

John A. McCracken, Edward E. Custer, and Justin C. Lamsa

Worcester Foundation for Biomedical Research, Shrewsbury, Massachusetts

McCracken, John A., Edward E. Custer, and Justin C. Lamsa. In many nonprimate mammalian species, cyclical regression of the corpus luteum (luteolysis) is caused by the episodic pulsatile secretion of uterine PGF2alpha , which acts either locally on the corpus luteum by a countercurrent mechanism or, in some species, via the systemic circulation. Hysterectomy in these nonprimate species causes maintenance of the corpora lutea, whereas in primates, removal of the uterus does not influence the cyclical regression of the corpus luteum. In several nonprimate species, the episodic pattern of uterine PGF2alpha secretion appears to be controlled indirectly by the ovarian steroid hormones estradiol-17beta and progesterone. It is proposed that, toward the end of the luteal phase, loss of progesterone action occurs both centrally in the hypothalamus and in the uterus due to the catalytic reduction (downregulation) of progesterone receptors by progesterone. Loss of progesterone action may permit the return of estrogen action, both centrally in the hypothalamus and peripherally in the uterus. Return of central estrogen action appears to cause the hypothalamic oxytocin pulse generator to alter its frequency and produce a series of intermittent episodes of oxytocin secretion. In the uterus, returning estrogen action concomitantly upregulates endometrial oxytocin receptors. The interaction of neurohypophysial oxytocin with oxytocin receptors in the endometrium evokes the secretion of luteolytic pulses of uterine PGF2alpha . Thus the uterus can be regarded as a transducer that converts intermittent neural signals from the hypothalamus, in the form of episodic oxytocin secretion, into luteolytic pulses of uterine PGF2alpha . In ruminants, portions of a finite store of luteal oxytocin are released synchronously by uterine PGF2alpha pulses. Luteal oxytocin in ruminants may thus serve to amplify neural oxytocin signals that are transduced by the uterus into pulses of PGF2alpha . Whether such amplification of episodic PGF2alpha pulses by luteal oxytocin is a necessary requirement for luteolysis in ruminants remains to be determined. Recently, oxytocin has been reported to be produced by the endometrium and myometrium of the sow, mare, and rat. It is possible that uterine production of oxytocin may act as a supplemental source of oxytocin during luteolysis in these species. In primates, oxytocin and its receptor and PGF2alpha and its receptor have been identified in the corpus luteum and/or ovary. Therefore, it is possible that oxytocin signals of ovarian and/or neural origin may be transduced locally at the ovarian level, thus explaining why luteolysis and ovarian cyclicity can proceed in the absence of the uterus in primates. However, it remains to be established whether the intraovarian process of luteolysis is mediated by arachidonic acid and/or its metabolite PGF2alpha and whether the central oxytocin pulse generator identified in nonprimate species plays a mediatory role during luteolysis in primates. Regardless of the mechanism, intraovarian luteolysis in primates (progesterone withdrawal) appears to be the primary stimulus for the subsequent production of endometrial prostaglandins associated with menstruation. In contrast, luteolysis in nonprimate species appears to depend on the prior production of endometrial prostaglandins. In primates, uterine prostaglandin production may reflect a vestigial mechanism that has been retained during evolution from an earlier dependence on uterine prostaglandin production for luteolysis.




This article has been cited by other articles:


Home page
 ReproductionHome page
V. A Sander, G. B Facorro, L. Piehl, E. Rubin de Celis, and A. B Motta
Effect of DHEA and metformin on corpus luteum in mice
Reproduction, September 1, 2009; 138(3): 571 - 579.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. R. Araujo, O.J. Ginther, J. C. Ferreira, M. M. Palhao, M. A. Beg, and M. C. Wiltbank
Role of Follicular Estradiol-17beta in Timing of Luteolysis in Heifers
Biol Reprod, August 1, 2009; 81(2): 426 - 437.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
O.J. Ginther, R.R. Araujo, M.P. Palhao, B.L. Rodrigues, and M.A. Beg
Necessity of Sequential Pulses of Prostaglandin F2alpha for Complete Physiologic Luteolysis in Cattle
Biol Reprod, April 1, 2009; 80(4): 641 - 648.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Priyanka, P. Jayaram, R. Sridaran, and R. Medhamurthy
Genome-Wide Gene Expression Analysis Reveals a Dynamic Interplay between Luteotropic and Luteolytic Factors in the Regulation of Corpus Luteum Function in the Bonnet Monkey (Macaca radiata)
Endocrinology, March 1, 2009; 150(3): 1473 - 1484.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. Krishnaswamy, P. Chapdelaine, J. P. Tremblay, and M. A. Fortier
Development and Characterization of a Simian Virus 40 Immortalized Bovine Endometrial Stromal Cell Line
Endocrinology, January 1, 2009; 150(1): 485 - 491.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
I. Woclawek-Potocka, J. Komiyama, J. S. Saulnier-Blache, E. Brzezicka, M. M. Bah, K. Okuda, and D. J Skarzynski
Lysophosphatic acid modulates prostaglandin secretion in the bovine uterus
Reproduction, January 1, 2009; 137(1): 95 - 105.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. L. Bogan, M. J. Murphy, R. L. Stouffer, and J. D. Hennebold
Prostaglandin Synthesis, Metabolism, and Signaling Potential in the Rhesus Macaque Corpus Luteum throughout the Luteal Phase of the Menstrual Cycle
Endocrinology, November 1, 2008; 149(11): 5861 - 5871.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. Bowolaksono, R. Nishimura, T. Hojo, R. Sakumoto, T. J. Acosta, and K. Okuda
Anti-Apoptotic Roles of Prostaglandin E2 and F2alpha in Bovine Luteal Steroidogenic Cells
Biol Reprod, August 1, 2008; 79(2): 310 - 317.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. Gonzalez-Fernandez, E. Martinez-Galisteo, F. Gaytan, J. A. Barcena, and J. E. Sanchez-Criado
Changes in the Proteome of Functional and Regressing Corpus Luteum During Pregnancy and Lactation in the Rat
Biol Reprod, July 1, 2008; 79(1): 100 - 114.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Komiyama, R. Nishimura, H.-Y. Lee, R. Sakumoto, M. Tetsuka, T. J. Acosta, D. J. Skarzynski, and K. Okuda
Cortisol Is a Suppressor of Apoptosis in Bovine Corpus Luteum
Biol Reprod, May 1, 2008; 78(5): 888 - 895.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. Ndiaye, D. H. Poole, and J. L. Pate
Expression and Regulation of Functional Oxytocin Receptors in Bovine T Lymphocytes
Biol Reprod, April 1, 2008; 78(4): 786 - 793.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. Nishimura, J. Komiyama, Y. Tasaki, T. J. Acosta, and K. Okuda
Hypoxia Promotes Luteal Cell Death in Bovine Corpus Luteum
Biol Reprod, March 1, 2008; 78(3): 529 - 536.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
F. Stormshak and C. V. Bishop
BOARD-INVITED REVIEW: Estrogen and progesterone signaling: Genomic and nongenomic actions in domestic ruminants
J Anim Sci, February 1, 2008; 86(2): 299 - 315.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. K. Banu, J. Lee, M. C. Satterfield, T. E. Spencer, F. W. Bazer, and J. A. Arosh
Molecular Cloning and Characterization of Prostaglandin (PG) Transporter in Ovine Endometrium: Role for Multiple Cell Signaling Pathways in Transport of PGF2{alpha}
Endocrinology, January 1, 2008; 149(1): 219 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. C. Peluffo, R. L. Stouffer, and M. Tesone
Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum
Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1215 - E1223.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Erdmann, A. Ricken, C. Merkwitz, I. Struman, R. Castino, K. Hummitzsch, F. Gaunitz, C. Isidoro, J. Martial, and K. Spanel-Borowski
The expression of prolactin and its cathepsin D-mediated cleavage in the bovine corpus luteum vary with the estrous cycle
Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1365 - E1377.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
Y. Chen, E. Antoniou, Z. Liu, L. B Hearne, and R M. Roberts
A microarray analysis for genes regulated by interferon-{tau} in ovine luminal epithelial cells
Reproduction, July 1, 2007; 134(1): 123 - 135.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
J. Nio and T. Iwanaga
Galectins in the Mouse Ovary: Concomitant Expression of Galectin-3 and Progesterone Degradation Enzyme (20{alpha}-HSD) in the Corpus Luteum
J. Histochem. Cytochem., May 1, 2007; 55(5): 423 - 432.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M Zerani, C Dall'Aglio, M Maranesi, A Gobbetti, G Brecchia, F Mercati, and C Boiti
Intraluteal regulation of prostaglandin F2{alpha}-induced prostaglandin biosynthesis in pseudopregnant rabbits
Reproduction, May 1, 2007; 133(5): 1005 - 1016.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
H.-Y. Lee, T. J Acosta, M. Tanikawa, R. Sakumoto, J. Komiyama, Y. Tasaki, M. Piskula, D. J Skarzynski, M. Tetsuka, and K. Okuda
The role of glucocorticoid in the regulation of prostaglandin biosynthesis in non-pregnant bovine endometrium
J. Endocrinol., April 1, 2007; 193(1): 127 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. J. Skarzynski, I. Woclawek-Potocka, A. Korzekwa, M. M. Bah, K. Piotrowska, B. Barszczewska, and K. Okuda
Infusion of Exogenous Tumor Necrosis Factor Dose Dependently Alters the Length of the Luteal Phase in Cattle: Differential Responses to Treatment with Indomethacin and L-NAME, a Nitric Oxide Synthase Inhibitor
Biol Reprod, April 1, 2007; 76(4): 619 - 627.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. Stocco, C. Telleria, and G. Gibori
The Molecular Control of Corpus Luteum Formation, Function, and Regression
Endocr. Rev., February 1, 2007; 28(1): 117 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Z. Naor, H. N. Jabbour, M. Naidich, A. J. Pawson, K. Morgan, S. Battersby, M. R. Millar, P. Brown, and R. P. Millar
Reciprocal Cross Talk between Gonadotropin-Releasing Hormone (GnRH) and Prostaglandin Receptors Regulates GnRH Receptor Expression and Differential Gonadotropin Secretion
Mol. Endocrinol., February 1, 2007; 21(2): 524 - 537.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
A. R. H. Moussavi, R. O. Gilbert, T. R. Overton, D. E. Bauman, and W. R. Butler
Effects of Feeding Fish Meal and n-3 Fatty Acids on Ovarian and Uterine Responses in Early Lactating Dairy Cows
J Dairy Sci, January 1, 2007; 90(1): 145 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. W. Arvisais, A. Romanelli, X. Hou, and J. S. Davis
AKT-independent Phosphorylation of TSC2 and Activation of mTOR and Ribosomal Protein S6 Kinase Signaling by Prostaglandin F2{alpha}
J. Biol. Chem., September 15, 2006; 281(37): 26904 - 26913.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Nishimura, R. Sakumoto, Y. Tatsukawa, T. J. Acosta, and K. Okuda
Oxygen Concentration Is an Important Factor for Modulating Progesterone Synthesis in Bovine Corpus Luteum
Endocrinology, September 1, 2006; 147(9): 4273 - 4280.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
H. Thackare, H. D. Nicholson, and K. Whittington
Oxytocin--its role in male reproduction and new potential therapeutic uses
Hum. Reprod. Update, July 1, 2006; 12(4): 437 - 448.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Chen, J. A. Green, E. Antoniou, A. D. Ealy, N. Mathialagan, A. M. Walker, M. P. Avalle, C. S. Rosenfeld, L. B. Hearne, and R. M. Roberts
Effect of Interferon-{tau} Administration on Endometrium of Nonpregnant Ewes: A Comparison with Pregnant Ewes
Endocrinology, May 1, 2006; 147(5): 2127 - 2137.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M. Parent, E. Madore, L. A MacLaren, and M. A Fortier
15-Hydroxyprostaglandin dehydrogenase in the bovine endometrium during the oestrous cycle and early pregnancy.
Reproduction, March 1, 2006; 131(3): 573 - 582.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. G. W. Fleming, T. E. Spencer, S. H. Safe, and F. W. Bazer
Estrogen Regulates Transcription of the Ovine Oxytocin Receptor Gene through GC-Rich SP1 Promoter Elements
Endocrinology, February 1, 2006; 147(2): 899 - 911.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Waclawik, A. Rivero-Muller, A. Blitek, M. M. Kaczmarek, L. J. S. Brokken, K. Watanabe, N. A. Rahman, and A. J. Ziecik
Molecular Cloning and Spatiotemporal Expression of Prostaglandin F Synthase and Microsomal Prostaglandin E Synthase-1 in Porcine Endometrium
Endocrinology, January 1, 2006; 147(1): 210 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M.P. Green, L.D. Spate, J.A. Bixby, A.D. Ealy, and R.M. Roberts
A Comparison of the Anti-Luteolytic Activities of Recombinant Ovine Interferon-Alpha and -Tau in Sheep
Biol Reprod, December 1, 2005; 73(6): 1087 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
S.K. Banu, J.A. Arosh, P. Chapdelaine, and M.A. Fortier
Expression of Prostaglandin Transporter in the Bovine Uterus and Fetal Membranes During Pregnancy
Biol Reprod, August 1, 2005; 73(2): 230 - 236.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
A. Blitek and A. J Ziecik
Effect of LH on prostaglandin F2{alpha} and prostaglandin E2 secretion by cultured porcine endometrial cells
Reproduction, July 1, 2005; 130(1): 105 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Parent and M. A. Fortier
Expression and Contribution of Three Different Isoforms of Prostaglandin E Synthase in the Bovine Endometrium
Biol Reprod, July 1, 2005; 73(1): 36 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
I. Woclawek-Potocka, T. J. Acosta, A. Korzekwa, M. M. Bah, M. Shibaya, K. Okuda, and D. J. Skarzynski
Phytoestrogens Modulate Prostaglandin Production in Bovine Endometrium: Cell Type Specificity and Intracellular Mechanisms
Experimental Biology and Medicine, May 1, 2005; 230(5): 326 - 333.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. Foyouzi, Z. Cai, Y. Sugimoto, and C. Stocco
Changes in the Expression of Steroidogenic and Antioxidant Genes in the Mouse Corpus Luteum During Luteolysis
Biol Reprod, May 1, 2005; 72(5): 1134 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. K. Yadav, G. Lakshmi, and R. Medhamurthy
Prostaglandin F2{alpha}-mediated Activation of Apoptotic Signaling Cascades in the Corpus Luteum during Apoptosis: INVOLVEMENT OF CASPASE-ACTIVATED DNase
J. Biol. Chem., March 18, 2005; 280(11): 10357 - 10367.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
I. Woclawek-Potocka, M. M. Bah, A. Korzekwa, M. K. Piskula, W. Wiczkowski, A. Depta, and D. J. Skarzynski
Soybean-Derived Phytoestrogens Regulate Prostaglandin Secretion in Endometrium During Cattle Estrous Cycle and Early Pregnancy
Experimental Biology and Medicine, March 1, 2005; 230(3): 189 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
M. R. Hussein
Apoptosis in the ovary: molecular mechanisms
Hum. Reprod. Update, March 1, 2005; 11(2): 162 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. P. Piekorz, S. Gingras, A. Hoffmeyer, J. N. Ihle, and Y. Weinstein
Regulation of Progesterone Levels during Pregnancy and Parturition by Signal Transducer and Activator of Transcription 5 and 20{alpha}-Hydroxysteroid Dehydrogenase
Mol. Endocrinol., February 1, 2005; 19(2): 431 - 440.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Shibaya, K. M. Deptula, A. Korzekwa, K. Okuda, and D. J. Skarzynski
Involvement of the Cytoskeleton in Oxytocin Secretion by Cultured Bovine Luteal Cells
Biol Reprod, January 1, 2005; 72(1): 200 - 205.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. Okuda, A. Korzekwa, M. Shibaya, S. Murakami, R. Nishimura, M. Tsubouchi, I. Woclawek-Potocka, and D. J. Skarzynski
Progesterone Is a Suppressor of Apoptosis in Bovine Luteal Cells
Biol Reprod, December 1, 2004; 71(6): 2065 - 2071.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. A. Arosh, S. K. Banu, S. Kimmins, P. Chapdelaine, L. A. MacLaren, and M. A. Fortier
Effect of Interferon-{tau} on Prostaglandin Biosynthesis, Transport, and Signaling at the Time of Maternal Recognition of Pregnancy in Cattle: Evidence of Polycrine Actions of Prostaglandin E2
Endocrinology, November 1, 2004; 145(11): 5280 - 5293.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
A. Guzeloglu, T. R. Bilby, A. Meikle, S. Kamimura, A. Kowalski, F. Michel, L. A. MacLaren, and W. W. Thatcher
Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy
J Dairy Sci, October 1, 2004; 87(10): 3268 - 3279.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E.M. Kolibianakis, K. Zikopoulos, J. Smitz, M. Camus, H. Tournaye, A.C. Van Steirteghem, and P. Devroey
Elevated progesterone at initiation of stimulation is associated with a lower ongoing pregnancy rate after IVF using GnRH antagonists
Hum. Reprod., July 1, 2004; 19(7): 1525 - 1529.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. E. Spencer, G. A. Johnson, R. C. Burghardt, and F. W. Bazer
Progesterone and Placental Hormone Actions on the Uterus: Insights from Domestic Animals
Biol Reprod, July 1, 2004; 71(1): 2 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. K. Goff
Steroid Hormone Modulation of Prostaglandin Secretion in the Ruminant Endometrium During the Estrous Cycle
Biol Reprod, July 1, 2004; 71(1): 11 - 16.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
S. Verma-Kumar, S V Srinivas, P Muraly, V. K Yadav, and R Medhamurthy
Cloning of a buffalo (Bubalus bubalis) prostaglandin F2{alpha} receptor: changes in its expression and concentration in the buffalo cow corpus luteum
Reproduction, June 1, 2004; 127(6): 705 - 715.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
J. D. Hennebold
Characterization of the ovarian transcriptome through the use of differential analysis of gene expression methodologies
Hum. Reprod. Update, May 1, 2004; 10(3): 227 - 239.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. A. Arosh, S. K. Banu, P. Chapdelaine, E. Madore, J. Sirois, and M. A. Fortier
Prostaglandin Biosynthesis, Transport, and Signaling in Corpus Luteum: A Basis for Autoregulation of Luteal Function
Endocrinology, May 1, 2004; 145(5): 2551 - 2560.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. Boerboom, K. A. Brown, D. Vaillancourt, P. Poitras, A. K. Goff, K. Watanabe, M. Dore, and J. Sirois
Expression of Key Prostaglandin Synthases in Equine Endometrium During Late Diestrus and Early Pregnancy
Biol Reprod, February 1, 2004; 70(2): 391 - 399.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. A. Arosh, S. K. Banu, P. Chapdelaine, and M. A. Fortier
Temporal and Tissue-Specific Expression of Prostaglandin Receptors EP2, EP3, EP4, FP, and Cyclooxygenases 1 and 2 in Uterus and Fetal Membranes during Bovine Pregnancy
Endocrinology, January 1, 2004; 145(1): 407 - 417.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
V. Emond, L. A. MacLaren, S. Kimmins, J. A. Arosh, M. A. Fortier, and R. D. Lambert
Expression of Cyclooxygenase-2 and Granulocyte-Macrophage Colony-Stimulating Factor in the Endometrial Epithelium of the Cow Is Up-Regulated During Early Pregnancy and in Response to Intrauterine Infusions of Interferon-{tau}
Biol Reprod, January 1, 2004; 70(1): 54 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. Okuda, Y. Kasahara, S. Murakami, H. Takahashi, I. Woclawek-Potocka, and D. J. Skarzynski
Interferon-{tau} Blocks the Stimulatory Effect of Tumor Necrosis Factor-{alpha} on Prostaglandin F2{alpha} Synthesis by Bovine Endometrial Stromal Cells
Biol Reprod, January 1, 2004; 70(1): 191 - 197.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. J. Skarzynski, M. M. Bah, K. M. Deptula, I. Woclawek-Potocka, A. Korzekwa, M. Shibaya, W. Pilawski, and K. Okuda
Roles of Tumor Necrosis Factor-{alpha} of the Estrous Cycle in Cattle: An In Vivo Study
Biol Reprod, December 1, 2003; 69(6): 1907 - 1913.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. K. Banu, J. A. Arosh, P. Chapdelaine, and M. A. Fortier
Molecular cloning and spatio-temporal expression of the prostaglandin transporter: A basis for the action of prostaglandins in the bovine reproductive system
PNAS, September 30, 2003; 100(20): 11747 - 11752.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. G. M. Beckers, N. S. Macklon, M. J. Eijkemans, M. Ludwig, R. E. Felberbaum, K. Diedrich, S. Bustion, E. Loumaye, and B. C. J. M. Fauser
Nonsupplemented Luteal Phase Characteristics after the Administration of Recombinant Human Chorionic Gonadotropin, Recombinant Luteinizing Hormone, or Gonadotropin-Releasing Hormone (GnRH) Agonist to Induce Final Oocyte Maturation in in Vitro Fertilization Patients after Ovarian Stimulation with Recombinant Follicle-Stimulating Hormone and GnRH Antagonist Cotreatment
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4186 - 4192.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. J. Skarzynski, J. J. Jaroszewski, M. M. Bah, K. M. Deptula, B. Barszczewska, B. Gawronska, and W. Hansel
Administration of a Nitric Oxide Synthase Inhibitor Counteracts Prostaglandin F2-Induced Luteolysis in Cattle
Biol Reprod, May 1, 2003; 68(5): 1674 - 1681.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Madore, N. Harvey, J. Parent, P. Chapdelaine, J. A. Arosh, and M. A. Fortier
An Aldose Reductase with 20alpha -Hydroxysteroid Dehydrogenase Activity Is Most Likely the Enzyme Responsible for the Production of Prostaglandin F2alpha in the Bovine Endometrium
J. Biol. Chem., March 21, 2003; 278(13): 11205 - 11212.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. L. Cook, M. C. Shallow, D. B. Zaragoza, K. I. Anderson, and D. M. Olson
Mouse Placental Prostaglandins Are Associated with Uterine Activation and the Timing of Birth
Biol Reprod, February 1, 2003; 68(2): 579 - 587.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. K. Pru, I. R. Hendry, J. S. Davis, and B. R. Rueda
Soluble Fas Ligand Activates the Sphingomyelin Pathway and Induces Apoptosis in Luteal Steroidogenic Cells Independently of Stress-Activated p38MAPK
Endocrinology, November 1, 2002; 143(11): 4350 - 4357.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. Nagaosa, A. Shiratsuchi, and Y. Nakanishi
Determination of Cell Type Specificity and Estrous Cycle Dependency of Monocyte Chemoattractant Protein-1 Expression in Corpora Lutea of Normally Cycling Rats in Relation to Apoptosis and Monocyte/Macrophage Accumulation
Biol Reprod, November 1, 2002; 67(5): 1502 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. A. Cavicchio, J. K. Pru, B. S. Davis, J. S. Davis, B. R. Rueda, and D. H. Townson
Secretion of Monocyte Chemoattractant Protein-1 by Endothelial Cells of the Bovine Corpus Luteum: Regulation by Cytokines But Not Prostaglandin F2{alpha}
Endocrinology, September 1, 2002; 143(9): 3582 - 3589.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
V. K. Yadav, R. R. Sudhagar, and R. Medhamurthy
Apoptosis During Spontaneous and Prostaglandin F2{alpha}-Induced Luteal Regression in the Buffalo Cow (Bubalus bubalis): Involvementof Mitogen-Activated Protein Kinases
Biol Reprod, September 1, 2002; 67(3): 752 - 759.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. A. Arosh, J. Parent, P. Chapdelaine, J. Sirois, and M. A. Fortier
Expression of Cyclooxygenases 1 and 2 and Prostaglandin E Synthase in Bovine Endometrial Tissue During the Estrous Cycle
Biol Reprod, July 1, 2002; 67(1): 161 - 169.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. A. Copland, M. G. Zlatnik, K. L. Ives, and M. S. Soloff
Oxytocin Receptor Regulation and Action in a Human Granulosa-Lutein Cell Line
Biol Reprod, May 1, 2002; 66(5): 1230 - 1236.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
Y.-L. Wu and M. C. Wiltbank
Transcriptional Regulation of the Cyclooxygenase-2 Gene Changes from Protein Kinase (PK) A- to PKC-Dependence after Luteinization of Granulosa Cells
Biol Reprod, May 1, 2002; 66(5): 1505 - 1514.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
T. A. Towle, P. C.W. Tsang, R. A. Milvae, M. K. Newbury, and J. A. McCracken
Dynamic In Vivo Changes in Tissue Inhibitors of Metalloproteinases 1 and 2, and Matrix Metalloproteinases 2 and 9, During Prostaglandin F2{alpha}-Induced Luteolysis in Sheep
Biol Reprod, May 1, 2002; 66(5): 1515 - 1521.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
C. O. Stocco, L. F. Lau, and G. Gibori
A Calcium/Calmodulin-dependent Activation of ERK1/2 Mediates JunD Phosphorylation and Induction of nur77 and 20alpha -hsd Genes by Prostaglandin F2alpha in Ovarian Cells
J. Biol. Chem., January 25, 2002; 277(5): 3293 - 3302.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. Zetser, T. Kisliouk, E. Ivakin, and M. Lahav
Dependence on Prolactin of the Luteolytic Effect of Prostaglandin F2{alpha} in Rat Luteal Cell Cultures
Biol Reprod, October 1, 2001; 65(4): 1082 - 1091.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Hu, T. E. Ludwig, U. Salli, F. Stormshak, and M. A. Mirando
Autocrine/Paracrine Action of Oxytocin in Pig Endometrium
Biol Reprod, June 1, 2001; 64(6): 1682 - 1688.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
G. Gimpl and F. Fahrenholz
The Oxytocin Receptor System: Structure, Function, and Regulation
Physiol Rev, April 1, 2001; 81(2): 629 - 683.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
L. E. Anderson, Y.-L. Wu, S.-J. Tsai, and M. C. Wiltbank
Prostaglandin F2{{alpha}} Receptor in the Corpus Luteum: Recent Information on the Gene, Messenger Ribonucleic Acid, and Protein
Biol Reprod, April 1, 2001; 64(4): 1041 - 1047.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
K. K. Olson, L. E. Anderson, M. C. Wiltbank, and D. H. Townson
Actions of Prostaglandin F2{{alpha}} and Prolactin on Intercellular Adhesion Molecule-1 Expression and Monocyte/Macrophage Accumulation in the Rat Corpus Luteum
Biol Reprod, March 1, 2001; 64(3): 890 - 897.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
T. Engstrøm, P. Bratholm, N. J. Christensen, and H. Vilhardt
Effect of Oxytocin Receptor Blockade on Rat Myometrial Responsiveness to Prostaglandin F2{alpha}
Biol Reprod, November 1, 2000; 63(5): 1443 - 1449.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
D. J. Skarzynski, S. Kobayashi, and K. Okuda
Influence of Nitric Oxide and Noradrenaline on Prostaglandin F2{alpha}-Induced Oxytocin Secretion and Intracellular Calcium Mobilization in Cultured Bovine Luteal Cells
Biol Reprod, October 1, 2000; 63(4): 1000 - 1005.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
Y. Miyamoto, D. J. Skarzynski, and K. Okuda
Is Tumor Necrosis Factor {alpha} a Trigger for the Initiation of Endometrial Prostaglandin F2{alpha} Release at Luteolysis in Cattle?
Biol Reprod, May 1, 2000; 62(5): 1109 - 1115.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
H. M. Fraser, S. E. Dickson, S. F. Lunn, C. Wulff, K. D. Morris, V. A. Carroll, and R. Bicknell
Suppression of Luteal Angiogenesis in the Primate after Neutralization of Vascular Endothelial Growth Factor
Endocrinology, March 1, 2000; 141(3): 995 - 1000.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online