| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
PHYSIOLOGICAL REVIEWS Vol. 79 No. 1 January 1999,
pp. S175-S191
Copyright ©1999 The American Physiological Society
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania
Bradbury, Neil A. Intracellular CFTR: Localization and Function. Physiol. Rev. 79, Suppl.: S175-S191, 1999. 
There is considerable evidence that CFTR can function as a chloride-selective anion channel. Moreover, this function has been localized to the apical membrane of chloride secretory epithelial cells. However, because cystic fibrosis transmembrane conductance regulator (CFTR) is an integral membrane protein, it will also be present, to some degree, in a variety of other membrane compartments (including endoplasmic reticulum, Golgi stacks, endosomes, and lysosomes). An incomplete understanding of the molecular mechanisms by which alterations in an apical membrane chloride conductance could give rise to the various clinical manifestations of cystic fibrosis has prompted the suggestion that CFTR may also play a role in the normal function of certain intracellular compartments. A variety of intracellular functions have been attributed to CFTR, including regulation of membrane vesicle trafficking and fusion, acidification of organelles, and transport of small anions. This paper aims to review the evidence for localization of CFTR in intracellular organelles and the potential physiological consequences of that localization.
This article has been cited by other articles:
|
|
 |
|
  Y. Guo, M. Su, M. A. McNutt, and J. Gu Expression and Distribution of Cystic Fibrosis Transmembrane Conductance Regulator in Neurons of the Human Brain J. Histochem. Cytochem., December 1, 2009; 57(12): 1113 - 1120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Merigo, D. Benati, M. Galie, C. Crescimanno, F. Osculati, and A. Sbarbati Immunohistochemical Localization of Cystic Fibrosis Transmembrane Regulator and Clara Cell Secretory Protein in Taste Receptor Cells of Rat Circumvallate Papillae Chem Senses, March 1, 2008; 33(3): 231 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Harada, T. Okiyoneda, Y. Hashimoto, K. Ueno, K. Nakamura, K. Yamahira, T. Sugahara, T. Shuto, I. Wada, M. A. Suico, et al. Calreticulin Negatively Regulates the Cell Surface Expression of Cystic Fibrosis Transmembrane Conductance Regulator J. Biol. Chem., May 5, 2006; 281(18): 12841 - 12848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Oertle, M. E. van der Haar, C. E. Bandtlow, A. Robeva, P. Burfeind, A. Buss, A. B. Huber, M. Simonen, L. Schnell, C. Brosamle, et al. Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions J. Neurosci., July 2, 2003; 23(13): 5393 - 5406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-S. Yoo, B. D. Moyer, S. Bannykh, H.-M. Yoo, J. R. Riordan, and W. E. Balch Non-conventional Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator through the Early Secretory Pathway J. Biol. Chem., March 22, 2002; 277(13): 11401 - 11409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Weixel and N. A. Bradbury The Carboxyl Terminus of the Cystic Fibrosis Transmembrane Conductance Regulator Binds to AP-2 Clathrin Adaptors J. Biol. Chem., February 4, 2000; 275(5): 3655 - 3660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liu, B. B. Singh, and I. S. Ambudkar ATP-dependent Activation of KCa and ROMK-type KATP Channels in Human Submandibular Gland Ductal Cells J. Biol. Chem., August 27, 1999; 274(35): 25121 - 25129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Riedel, O. Levy, and N. Carrasco Post-transcriptional Regulation of the Sodium/Iodide Symporter by Thyrotropin J. Biol. Chem., June 8, 2001; 276(24): 21458 - 21463. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
