Physiol Rev AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 78: 1193-1231, 1998;
0031-9333/98 $15.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by JONES, G.
Right arrow Articles by DeLUCA, H. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by JONES, G.
Right arrow Articles by DeLUCA, H. F.

PHYSIOLOGICAL REVIEWS   Vol. 78 No. 4 October 1998, pp. 1193-1231
Copyright ©1998 The American Physiological Society

Current Understanding of the Molecular Actions of Vitamin D

GLENVILLE JONES, STEPHEN A. STRUGNELL, AND HECTOR F. DeLUCA

Departments of Biochemistry and Medicine, Queen's University, Kingston, Ontario, Canada; and Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin

Jones, Glenville, Stephen A. Strugnell, and Hector F. DeLuca. Current Understanding of the Molecular Actions of Vitamin D. Physiol. Rev. 78: 1193-1231, 1998. --- The important reactions that occur to the vitamin D molecule and the important reactions involved in the expression of the final active form of vitamin D are reviewed in a critical manner. After an overview of the metabolism of vitamin D to its active form and to its metabolic degradation products, the molecular understanding of the 1alpha -hydroxylation reaction and the 24-hydroxylation reaction of the vitamin D hormone is presented. Furthermore, the role of vitamin D in maintenance of serum calcium is reviewed at the physiological level and at the molecular level whenever possible. Of particular importance is the regulation of the parathyroid gland by the vitamin D hormone. A third section describes the known molecular events involved in the action of 1alpha ,25-dihydroxyvitamin D3 on its target cells. This includes reviewing what is now known concerning the overall mechanism of transcriptional regulation by vitamin D. It describes the vitamin D receptors that have been cloned and identified and describes the coactivators and retinoid X receptors required for the function of vitamin D in its genomic actions. The presence of receptor in previously uncharted target organs of vitamin D action has led to a study of the possible function of vitamin D in these organs. A good example of a new function described for 1alpha ,25-dihydroxyvitamin D3 is that found in the parathyroid gland. This is also true for the role of vitamin D hormone in skin, the immune system, a possible role in the pancreas, i.e., in the islet cells, and a possible role in female reproduction. This review also raises the intriguing question of whether vitamin D plays an important role in embryonic development, since vitamin D deficiency does not prohibit development, nor does vitamin D receptor knockout. The final section reviews some interesting analogs of the vitamin D hormone and their possible uses. The review ends with possible ideas with regard to future directions of vitamin D drug design.




This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. Jenab, J. McKay, H. B. Bueno-de-Mesquita, F. J.B. van Duijnhoven, P. Ferrari, N. Slimani, E. H.J.M. Jansen, T. Pischon, S. Rinaldi, A. Tjonneland, et al.
Vitamin D Receptor and Calcium Sensing Receptor Polymorphisms and the Risk of Colorectal Cancer in European Populations
Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2485 - 2491.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Ishizawa, K.-i. Iwasaki, S. Kato, and M. Makishima
Hypergravity modulates vitamin D receptor target gene mRNA expression in mice
Am J Physiol Endocrinol Metab, September 1, 2009; 297(3): E728 - E734.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. A. Zella, M. B. Meyer, R. D. Nerenz, and J. W. Pike
The Enhanced Hypercalcemic Response to 20-Epi-1,25-Dihydroxyvitamin D3 Results from a Selective and Prolonged Induction of Intestinal Calcium-Regulating Genes
Endocrinology, August 1, 2009; 150(8): 3448 - 3456.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
D. M Lee, A. Tajar, A. Ulubaev, N. Pendleton, T. W O'Neill, D. B O'Connor, G. Bartfai, S. Boonen, R. Bouillon, F. F Casanueva, et al.
Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men
J. Neurol. Neurosurg. Psychiatry, July 1, 2009; 80(7): 722 - 729.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. E. Wong, F. L. Szeto, W. Zhang, H. Ye, J. Kong, Z. Zhang, X. J. Sun, and Y. C. Li
Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins
Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E820 - E828.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. R. Becklund, D. W. Hansen Jr., and H. F. DeLuca
Enhancement of 1,25-dihydroxyvitamin D3-mediated suppression of experimental autoimmune encephalomyelitis by calcitonin
PNAS, March 31, 2009; 106(13): 5276 - 5281.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Y. Konno, S. Kodama, R. Moore, N. Kamiya, and M. Negishi
Nuclear Xenobiotic Receptor Pregnane X Receptor Locks Corepressor Silencing Mediator for Retinoid and Thyroid Hormone Receptors (SMRT) onto the CYP24A1 Promoter to Attenuate Vitamin D3 Activation
Mol. Pharmacol., February 1, 2009; 75(2): 265 - 271.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. D. Kutuzova, F. Sundersingh, J. Vaughan, B. P. Tadi, S. E. Ansay, S. Christakos, and H. F. DeLuca
TRPV6 is not required for 1{alpha},25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo
PNAS, December 16, 2008; 105(50): 19655 - 19659.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. H. White
Vitamin D Signaling, Infectious Diseases, and Regulation of Innate Immunity
Infect. Immun., September 1, 2008; 76(9): 3837 - 3843.
[Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
P. M Brannon, E. A Yetley, R. L Bailey, and M. F. Picciano
Overview of the conference "Vitamin D and Health in the 21st Century: an Update"
Am. J. Clinical Nutrition, August 1, 2008; 88(2): 483S - 490S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
G. Jones
Pharmacokinetics of vitamin D toxicity
Am. J. Clinical Nutrition, August 1, 2008; 88(2): 582S - 586S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. J. Menezes, R. T. Cheney, A. Husain, M. Tretiakova, G. Loewen, C. S. Johnson, V. Jayaprakash, K. B. Moysich, R. Salgia, and M. E. Reid
Vitamin D Receptor Expression in Normal, Premalignant, and Malignant Human Lung Tissue
Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1104 - 1110.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
G. S Bevelander, E. S L C Pinto, A. V M Canario, T. Spanings, and G. Flik
CYP27A1 expression in gilthead sea bream (Sparus auratus, L.): effects of calcitriol and parathyroid hormone-related protein
J. Endocrinol., March 1, 2008; 196(3): 625 - 635.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
G Priya, V P Jyotsna, N Gupta, S Chumber, C S Bal, A K Karak, A Seth, and A C Ammini
Clinical and laboratory profile of primary hyperparathyroidism in India
Postgrad. Med. J., January 1, 2008; 84(987): 34 - 39.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
Y.-C. Lin, L.-C. Hsieh, M.-W. Kuo, J. Yu, H.-H. Kuo, W.-L. Lo, R.-J. Lin, A. L. Yu, and W.-H. Li
Human TRIM71 and Its Nematode Homologue Are Targets of let-7 MicroRNA and Its Zebrafish Orthologue Is Essential for Development
Mol. Biol. Evol., November 1, 2007; 24(11): 2525 - 2534.
[Abstract] [Full Text] [PDF]

Home page
 Biol Res NursHome page
P. T. Alpert and U. Shaikh
The Effects of Vitamin D Deficiency and Insufficiency on the Endocrine and Paracrine Systems
Biol Res Nurs, October 1, 2007; 9(2): 117 - 129.
[Abstract] [PDF]

Home page
 DiabetesHome page
R. Bailey, J. D. Cooper, L. Zeitels, D. J. Smyth, J. H.M. Yang, N. M. Walker, E. Hypponen, D. B. Dunger, E. Ramos-Lopez, K. Badenhoop, et al.
Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes
Diabetes, October 1, 2007; 56(10): 2616 - 2621.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
Y. Arnson, H. Amital, and Y. Shoenfeld
Vitamin D and autoimmunity: new aetiological and therapeutic considerations
Ann Rheum Dis, September 1, 2007; 66(9): 1137 - 1142.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. B. Meyer, L. A. Zella, R. D. Nerenz, and J. W. Pike
Characterizing Early Events Associated with the Activation of Target Genes by 1,25-Dihydroxyvitamin D3 in Mouse Kidney and Intestine in Vivo
J. Biol. Chem., August 3, 2007; 282(31): 22344 - 22352.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Chen, G. P. Sims, X. X. Chen, Y. Y. Gu, S. Chen, and P. E. Lipsky
Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation
J. Immunol., August 1, 2007; 179(3): 1634 - 1647.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. E. Prosser, M. Kaufmann, B. O'Leary, V. Byford, and G. Jones
Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1{alpha},25-(OH)2D3-26,23-lactone
PNAS, July 31, 2007; 104(31): 12673 - 12678.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
A. Agic, Hong Xu, C. Altgassen, F. Noack, M. M. Wolfler, K. Diedrich, M. Friedrich, R. N. Taylor, and D. Hornung
Relative Expression of 1,25-Dihydroxyvitamin D3 Receptor, Vitamin D 1{alpha}-Hydroxylase, Vitamin D 24-Hydroxylase, and Vitamin D 25-Hydroxylase in Endometriosis and Gynecologic Cancers
Reproductive Sciences, July 1, 2007; 14(5): 486 - 497.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
S. Wu, S. Ren, L. Nguyen, J. S. Adams, and M. Hewison
Splice Variants of the CYP27b1 Gene and the Regulation of 1,25-Dihydroxyvitamin D3 Production
Endocrinology, July 1, 2007; 148(7): 3410 - 3418.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. A. Nehring, C. Zierold, and H. F. DeLuca
Lithocholic acid can carry out in vivo functions of vitamin D
PNAS, June 12, 2007; 104(24): 10006 - 10009.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
E J Lock, R Ornsrud, L Aksnes, F A T Spanings, R Waagbo, and G Flik
The vitamin D receptor and its ligand 1{alpha},25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar)
J. Endocrinol., June 1, 2007; 193(3): 459 - 471.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. B. Williams and H. F. DeLuca
Characterization of intestinal phosphate absorption using a novel in vivo method
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1917 - E1921.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. I. Ellison, R. L. Eckert, and P. N. MacDonald
Evidence for 1,25-Dihydroxyvitamin D3-independent Transactivation by the Vitamin D Receptor: UNCOUPLING THE RECEPTOR AND LIGAND IN KERATINOCYTES
J. Biol. Chem., April 13, 2007; 282(15): 10953 - 10962.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q.-P. Li, X. Qi, R. Pramanik, N. M. Pohl, M. Loesch, and G. Chen
Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity
J. Biol. Chem., January 19, 2007; 282(3): 1544 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. H. Samander and A. Arnold
Mutational Analysis of the Vitamin D Receptor Does Not Support Its Candidacy as a Tumor Suppressor Gene in Parathyroid Adenomas
J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5019 - 5021.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. N. Evans, L. Nguyen, J. Chan, B. A. Innes, J. N. Bulmer, M. D. Kilby, and M. Hewison
Effects of 25-Hydroxyvitamin D3 and 1,25-Dihydroxyvitamin D3 on Cytokine Production by Human Decidual Cells
Biol Reprod, December 1, 2006; 75(6): 816 - 822.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. Sundaram, M. J. Beckman, A. Bajwa, J. Wei, K. M. Smith, G. H. Posner, and D. A. Gewirtz
QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells.
Mol. Cancer Ther., November 1, 2006; 5(11): 2806 - 2814.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Overbergh, K. Stoffels, M. Waer, A. Verstuyf, R. Bouillon, and C. Mathieu
Immune Regulation of 25-Hydroxyvitamin D-1{alpha}-Hydroxylase in Human Monocytic THP1 Cells: Mechanisms of Interferon-{gamma}-Mediated Induction
J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3566 - 3574.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. D. Kutuzova, S. Akhter, S. Christakos, J. Vanhooke, C. Kimmel-Jehan, and H. F. DeLuca
Calbindin D9k knockout mice are indistinguishable from wild-type mice in phenotype and serum calcium level
PNAS, August 15, 2006; 103(33): 12377 - 12381.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Li, P. Hener, Z. Zhang, S. Kato, D. Metzger, and P. Chambon
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis
PNAS, August 1, 2006; 103(31): 11736 - 11741.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
P Vigano, D Lattuada, S Mangioni, L Ermellino, M Vignali, E Caporizzo, P Panina-Bordignon, M Besozzi, and A M Di Blasio
Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system.
J. Mol. Endocrinol., June 1, 2006; 36(3): 415 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. Zierold, J. A. Mings, and H. F. Deluca
19nor-1,25-Dihydroxyvitamin D2 Specifically Induces CYP3A9 in Rat Intestine More Strongly than 1,25-Dihydroxyvitamin D3 in Vivo and in Vitro
Mol. Pharmacol., May 1, 2006; 69(5): 1740 - 1747.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Blumberg, I. Tzameli, I. Astapova, F. S. Lam, J. S. Flier, and A. N. Hollenberg
Complex Role of the Vitamin D Receptor and Its Ligand in Adipogenesis in 3T3-L1 Cells
J. Biol. Chem., April 21, 2006; 281(16): 11205 - 11213.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Seoane and R. Perez-Fernandez
The Vitamin D Receptor Represses Transcription of the Pituitary Transcription Factor Pit-1 Gene without Involvement of the Retinoid X Receptor
Mol. Endocrinol., April 1, 2006; 20(4): 735 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. Masuda and G. Jones
Promise of vitamin D analogues in the treatment of hyperproliferative conditions.
Mol. Cancer Ther., April 1, 2006; 5(4): 797 - 808.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. J. Brown, C. S. Ritter, J. C. Knutson, and S. A. Strugnell
The vitamin D prodrugs 1{alpha}(OH)D2, 1{alpha}(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells
Nephrol. Dial. Transplant., March 1, 2006; 21(3): 644 - 650.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. L. Vanhooke, J. M. Prahl, C. Kimmel-Jehan, M. Mendelsohn, E. W. Danielson, K. D. Healy, and H. F. DeLuca
CYP27B1 null mice with LacZreporter gene display no 25-hydroxyvitamin D3-1{alpha}-hydroxylase promoter activity in the skin
PNAS, January 3, 2006; 103(1): 75 - 80.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T.-T. Wang, L. E. Tavera-Mendoza, D. Laperriere, E. Libby, N. Burton MacLeod, Y. Nagai, V. Bourdeau, A. Konstorum, B. Lallemant, R. Zhang, et al.
Large-Scale in Silico and Microarray-Based Identification of Direct 1,25-Dihydroxyvitamin D3 Target Genes
Mol. Endocrinol., November 1, 2005; 19(11): 2685 - 2695.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Matilainen, M. Malinen, K. Saavalainen, and C. Carlberg
Regulation of multiple insulin-like growth factor binding protein genes by 1{alpha},25-dihydroxyvitamin D3
Nucleic Acids Res., September 26, 2005; 33(17): 5521 - 5532.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. Diesel, J. Radermacher, M. Bureik, R. Bernhardt, M. Seifert, J. Reichrath, U. Fischer, and E. Meese
Vitamin D3 Metabolism in Human Glioblastoma Multiforme: Functionality of CYP27B1 Splice Variants, Metabolism of Calcidiol, and Effect of Calcitriol
Clin. Cancer Res., August 1, 2005; 11(15): 5370 - 5380.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C. M. Rohde and H. F. DeLuca
All-trans Retinoic Acid Antagonizes the Action of Calciferol and Its Active Metabolite, 1,25-Dihydroxycholecalciferol, in Rats
J. Nutr., July 1, 2005; 135(7): 1647 - 1652.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
P. P Dwivedi, P. H Anderson, J. L Omdahl, H L. Grimes, H. A Morris, and B. K May
Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells
Endocr. Relat. Cancer, June 1, 2005; 12(2): 351 - 365.
[Abstract] [Full Text] [PDF]

Home page
 IBMS BoneKEyHome page
B.E. C. Nordin and A. G. Need
The Relation Between Serum Calcidiol and Calcitriol
IBMS BoneKEy, May 1, 2005; 2(5): 7 - 16.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
J. G. J. Hoenderop and R. J. M. Bindels
Is vitamin D indispensable for Ca2+ homeostasis: lessons from knockout mouse models?
Nephrol. Dial. Transplant., May 1, 2005; 20(5): 864 - 867.
[Full Text] [PDF]

Home page
 J. Lipid Res.Home page
E. Fahy, S. Subramaniam, H. A. Brown, C. K. Glass, A. H. Merrill Jr., R. C. Murphy, C. R. H. Raetz, D. W. Russell, Y. Seyama, W. Shaw, et al.
A comprehensive classification system for lipids
J. Lipid Res., May 1, 2005; 46(5): 839 - 862.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Townsend, C. M. Banwell, M. Guy, K. W. Colston, J. L. Mansi, P. M. Stewart, M. J. Campbell, and M. Hewison
Autocrine Metabolism of Vitamin D in Normal and Malignant Breast Tissue
Clin. Cancer Res., May 1, 2005; 11(9): 3579 - 3586.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Kumagai, L.-Y. Shih, S. V. Hughes, J. C. Desmond, J. O'Kelly, M. Hewison, and H. P. Koeffler
19-Nor-1,25(OH)2D2 (a Novel, Noncalcemic Vitamin D Analogue), Combined with Arsenic Trioxide, Has Potent Antitumor Activity against Myeloid Leukemia
Cancer Res., March 15, 2005; 65(6): 2488 - 2497.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
L. Schneider, C. El-Yazidi, A. Dace, M. Maraninchi, R. Planells, A. Margotat, and J. Torresani
Expression of the 1,25-(OH)2 vitamin D3 receptor gene during the differentiation of mouse Ob17 preadipocytes and cross talk with the thyroid hormone receptor signalling pathway
J. Mol. Endocrinol., February 1, 2005; 34(1): 221 - 235.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
I Hendrix, P H Anderson, J L Omdahl, B K May, and H A Morris
Response of the 5'-flanking region of the human 25-hydroxyvitamin D 1{alpha}-hydroxylase gene to physiological stimuli using a transgenic mouse model
J. Mol. Endocrinol., February 1, 2005; 34(1): 237 - 245.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Masuda, V. Byford, A. Arabian, Y. Sakai, M. B. Demay, R. St-Arnaud, and G. Jones
Altered Pharmacokinetics of 1{alpha},25-Dihydroxyvitamin D3 and 25-Hydroxyvitamin D3 in the Blood and Tissues of the 25-Hydroxyvitamin D-24-Hydroxylase (Cyp24a1) Null Mouse
Endocrinology, February 1, 2005; 146(2): 825 - 834.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. G. J. Hoenderop, B. Nilius, and R. J. M. Bindels
Calcium Absorption Across Epithelia
Physiol Rev, January 1, 2005; 85(1): 373 - 422.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
H. F DeLuca
Overview of general physiologic features and functions of vitamin D
Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1689S - 1696S.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Swamy, T. C. Chen, S. Peleg, P. Dhawan, S. Christakos, L. V. Stewart, N. L. Weigel, R. G. Mehta, M. F. Holick, and R. Ray
Inhibition of Proliferation and Induction of Apoptosis by 25-Hydroxyvitamin D3-3{beta}-(2)-Bromoacetate, a Nontoxic and Vitamin D Receptor-Alkylating Analog of 25-Hydroxyvitamin D3 in Prostate Cancer Cells
Clin. Cancer Res., December 1, 2004; 10(23): 8018 - 8027.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. Nejentsev, J. D. Cooper, L. Godfrey, J. M.M. Howson, H. Rance, S. Nutland, N. M. Walker, C. Guja, C. Ionescu-Tirgoviste, D. A. Savage, et al.
Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes
Diabetes, October 1, 2004; 53(10): 2709 - 2712.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. N. Evans, H. Taylor, D. Zehnder, M. D. Kilby, J. N. Bulmer, F. Shah, J. S. Adams, and M. Hewison
Increased Expression of 25-Hydroxyvitamin D-1{alpha}-Hydroxylase in Dysgerminomas: A Novel Form of Humoral Hypercalcemia of Malignancy
Am. J. Pathol., September 1, 2004; 165(3): 807 - 813.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. Nejentsev, L. Godfrey, H. Snook, H. Rance, S. Nutland, N. M. Walker, A. C. Lam, C. Guja, C. Ionescu-Tirgoviste, D. E. Undlien, et al.
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene
Hum. Mol. Genet., August 1, 2004; 13(15): 1633 - 1639.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
K. M. Spach, L. B. Pedersen, F. E. Nashold, T. Kayo, B. S. Yandell, T. A. Prolla, and C. E. Hayes
Gene expression analysis suggests that 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis
Physiol Genomics, July 8, 2004; 18(2): 141 - 151.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
K. N. Evans, J. N. Bulmer, M. D. Kilby, and M. Hewison
Vitamin D and Placental-Decidual Function
Reproductive Sciences, July 1, 2004; 11(5): 263 - 271.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
T. Yamasaki, S. Izumi, H. Ide, and Y. Ohyama
Identification of a Novel Rat Microsomal Vitamin D3 25-Hydroxylase
J. Biol. Chem., May 28, 2004; 279(22): 22848 - 22856.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Qi, J. Tang, R. Pramanik, R. M. Schultz, S. Shirasawa, T. Sasazuki, J. Han, and G. Chen
p38 MAPK Activation Selectively Induces Cell Death in K-ras-mutated Human Colon Cancer Cells through Regulation of Vitamin D Receptor
J. Biol. Chem., May 21, 2004; 279(21): 22138 - 22144.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. B. Cheng, M. A. Levine, N. H. Bell, D. J. Mangelsdorf, and D. W. Russell
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
PNAS, May 18, 2004; 101(20): 7711 - 7715.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. Plum, J. M. Prahl, X. Ma, R. R. Sicinski, S. Gowlugari, M. Clagett-Dame, and H. F. DeLuca
Biologically active noncalcemic analogs of 1{alpha},25-dihydroxyvitamin D with an abbreviated side chain containing no hydroxyl
PNAS, May 4, 2004; 101(18): 6900 - 6904.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Kamao, S. Tatematsu, S. Hatakeyama, T. Sakaki, N. Sawada, K. Inouye, K. Ozono, N. Kubodera, G. S. Reddy, and T. Okano
C-3 Epimerization of Vitamin D3 Metabolites and Further Metabolism of C-3 Epimers: 25-HYDROXYVITAMIN D3 IS METABOLIZED TO 3-EPI-25-HYDROXYVITAMIN D3 AND SUBSEQUENTLY METABOLIZED THROUGH C-1{alpha} OR C-24 HYDROXYLATION
J. Biol. Chem., April 16, 2004; 279(16): 15897 - 15907.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. K. Panda, D. Miao, I. Bolivar, J. Li, R. Huo, G. N. Hendy, and D. Goltzman
Inactivation of the 25-Hydroxyvitamin D 1{alpha}-Hydroxylase and Vitamin D Receptor Demonstrates Independent and Interdependent Effects of Calcium and Vitamin D on Skeletal and Mineral Homeostasis
J. Biol. Chem., April 16, 2004; 279(16): 16754 - 16766.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
L. V. Stewart and N. L. Weigel
Vitamin D and Prostate Cancer
Experimental Biology and Medicine, April 1, 2004; 229(4): 277 - 284.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
F. Barletta, P. Dhawan, and S. Christakos
Integration of hormone signaling in the regulation of human 25(OH)D3 24-hydroxylase transcription
Am J Physiol Endocrinol Metab, April 1, 2004; 286(4): E598 - E608.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Thomas, P. Moffatt, P. Salois, M.-H. Gaumond, R. Gingras, E. Godin, D. Miao, D. Goltzman, and C. Lanctot
Osteocrin, a Novel Bone-specific Secreted Protein That Modulates the Osteoblast Phenotype
J. Biol. Chem., December 12, 2003; 278(50): 50563 - 50571.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
O. Guryev, R. A. Carvalho, S. Usanov, A. Gilep, and R. W. Estabrook
A pathway for the metabolism of vitamin D3: Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)
PNAS, December 9, 2003; 100(25): 14754 - 14759.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Dong, T. Craig, N. Xing, L. A. Bachman, C. V. Paya, F. Weih, D. J. McKean, R. Kumar, and M. D. Griffin
Direct Transcriptional Regulation of RelB by 1{alpha},25-Dihydroxyvitamin D3 and Its Analogs: PHYSIOLOGIC AND THERAPEUTIC IMPLICATIONS FOR DENDRITIC CELL FUNCTION
J. Biol. Chem., December 5, 2003; 278(49): 49378 - 49385.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Yokomura, T. Suda, S. Sasaki, N. Inui, K. Chida, and H. Nakamura
Increased Expression of the 25-Hydroxyvitamin D3-1{alpha}-Hydroxylase Gene in Alveolar Macrophages of Patients with Lung Cancer
J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5704 - 5709.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Tsujikawa, Y. Kurotaki, T. Fujimori, K. Fukuda, and Y.-I. Nabeshima
Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System
Mol. Endocrinol., December 1, 2003; 17(12): 2393 - 2403.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. W. Good, T. George, and B. A. Watts III
Aldosterone potentiates 1,25-dihydroxyvitamin D3 action in renal thick ascending limb via a nongenomic, ERK-dependent pathway
Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1122 - C1130.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-C. Hsieh, J. M. Sisk, P. W. Jurutka, C. A. Haussler, S. A. Slater, M. R. Haussler, and C. C. Thompson
Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling
J. Biol. Chem., October 3, 2003; 278(40): 38665 - 38674.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. B. Cheng, D. L. Motola, D. J. Mangelsdorf, and D. W. Russell
De-orphanization of Cytochrome P450 2R1: A MICROSOMAL VITAMIN D 25-HYDROXYLASE
J. Biol. Chem., September 26, 2003; 278(39): 38084 - 38093.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Yamamoto, N. K. Shevde, A. Warrier, L. A. Plum, H. F. DeLuca, and J. W. Pike
2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 Potently Stimulates Gene-specific DNA Binding of the Vitamin D Receptor in Osteoblasts
J. Biol. Chem., August 22, 2003; 278(34): 31756 - 31765.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
T. Kumagai, J. O'Kelly, J. W. Said, and H. P. Koeffler
Vitamin D2 Analog 19-nor-1,25-Dihydroxyvitamin D2: Antitumor Activity Against Leukemia, Myeloma, and Colon Cancer Cells
J Natl Cancer Inst, June 18, 2003; 95(12): 896 - 905.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Hewison, L. Freeman, S. V. Hughes, K. N. Evans, R. Bland, A. G. Eliopoulos, M. D. Kilby, P. A. H. Moss, and R. Chakraverty
Differential Regulation of Vitamin D Receptor and Its Ligand in Human Monocyte-Derived Dendritic Cells
J. Immunol., June 1, 2003; 170(11): 5382 - 5390.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. L. M. Sutton and P. N. MacDonald
Vitamin D: More Than a "Bone-a-Fide" Hormone
Mol. Endocrinol., May 1, 2003; 17(5): 777 - 791.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. J. Armbrecht, M. A. Boltz, and T. L. Hodam
PTH increases renal 25(OH)D3-1alpha -hydroxylase (CYP1alpha ) mRNA but not renal 1,25(OH)2D3 production in adult rats
Am J Physiol Renal Physiol, May 1, 2003; 284(5): F1032 - F1036.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
R. A. Upton, J. C. Knutson, C. W. Bishop, and L. W. LeVan
Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone
Nephrol. Dial. Transplant., April 1, 2003; 18(4): 750 - 758.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X.-Y. Bai, D. Miao, D. Goltzman, and A. C. Karaplis
The Autosomal Dominant Hypophosphatemic Rickets R176Q Mutation in Fibroblast Growth Factor 23 Resists Proteolytic Cleavage and Enhances in Vivo Biological Potency
J. Biol. Chem., March 7, 2003; 278(11): 9843 - 9849.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Lin, T. T. Wang, W. H. Miller Jr., and J. H. White
Inhibition of F-Box Protein p45SKP2 Expression and Stabilization of Cyclin-Dependent Kinase Inhibitor p27KIP1 in Vitamin D Analog-Treated Cancer Cells
Endocrinology, March 1, 2003; 144(3): 749 - 753.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Larsson, I. Nemere, L. Aksnes, and K. Sundell
Environmental Salinity Regulates Receptor Expression, Cellular Effects, and Circulating Levels of Two Antagonizing Hormones, 1,25-Dihydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3, in Rainbow Trout
Endocrinology, February 1, 2003; 144(2): 559 - 566.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. Hirata, K. Makibayashi, K. Katsumata, K. Kusano, T. Watanabe, N. Fukushima, and T. Doi
22-Oxacalcitriol prevents progressive glomerulosclerosis without adversely affecting calcium and phosphorus metabolism in subtotally nephrectomized rats
Nephrol. Dial. Transplant., December 1, 2002; 17(12): 2132 - 2137.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. Brigelius-Flohe, F. J Kelly, J. T Salonen, J. Neuzil, J.-M. Zingg, and A. Azzi
The European perspective on vitamin E: current knowledge and future research
Am. J. Clinical Nutrition, October 1, 2002; 76(4): 703 - 716.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. F. Raposo, L. G. Sobrinho, and H. G. Ferreira
A Minimal Mathematical Model of Calcium Homeostasis
J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4330 - 4340.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. P. Dwivedi, C. S. T. Hii, A. Ferrante, J. Tan, C. J. Der, J. L. Omdahl, H. A. Morris, and B. K. May
Role of MAP Kinases in the 1,25-Dihydroxyvitamin D3-induced Transactivation of the Rat Cytochrome P450C24 (CYP24) Promoter. SPECIFIC FUNCTIONS FOR ERK1/ERK2 AND ERK5
J. Biol. Chem., August 9, 2002; 277(33): 29643 - 29653.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
B. R. Wiegand, J. C. Sparks, D. C. Beitz, F. C. Parrish Jr., R. L. Horst, A. H. Trenkle, and R. C. Ewan
Short-term feeding of vitamin D3 improves color but does not change tenderness of pork-loin chops
J Anim Sci, August 1, 2002; 80(8): 2116 - 2121.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
L. E. Johnson and H. F. DeLuca
Reproductive Defects Are Corrected in Vitamin D-Deficient Female Rats Fed a High Calcium, Phosphorus and Lactose Diet
J. Nutr., August 1, 2002; 132(8): 2270 - 2273.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Qi, R. Pramanik, J. Wang, R. M. Schultz, R. K. Maitra, J. Han, H. F. DeLuca, and G. Chen
The p38 and JNK Pathways Cooperate to trans-Activate Vitamin D Receptor via c-Jun/AP-1 and Sensitize Human Breast Cancer Cells to Vitamin D3-induced Growth Inhibition
J. Biol. Chem., July 12, 2002; 277(29): 25884 - 25892.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. C. Rebsamen, J. Sun, A. W. Norman, and J. K. Liao
1{alpha},25-Dihydroxyvitamin D3 Induces Vascular Smooth Muscle Cell Migration via Activation of Phosphatidylinositol 3-Kinase
Circ. Res., July 12, 2002; 91(1): 17 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
J. V. Chithalen, L. Luu, M. Petkovich, and G. Jones
HPLC-MS/MS analysis of the products generated from all-trans-retinoic acid using recombinant human CYP26A
J. Lipid Res., July 1, 2002; 43(7): 1133 - 1142.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. G. Erben, D. W. Soegiarto, K. Weber, U. Zeitz, M. Lieberherr, R. Gniadecki, G. Moller, J. Adamski, and R. Balling
Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D
Mol. Endocrinol., July 1, 2002; 16(7): 1524 - 1537.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. Zehnder, K. N. Evans, M. D. Kilby, J. N. Bulmer, B. A. Innes, P. M. Stewart, and M. Hewison
The Ontogeny of 25-Hydroxyvitamin D3 1{alpha}-Hydroxylase Expression in Human Placenta and Decidua
Am. J. Pathol., July 1, 2002; 161(1): 105 - 114.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
U. Segersten, P. Correa, M. Hewison, P. Hellman, H. Dralle, T. Carling, G. Akerstrom, and G. Westin
25-Hydroxyvitamin D3-1{alpha}-Hydroxylase Expression in Normal and Pathological Parathyroid Glands
J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2967 - 2972.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. Lin, Y. Nagai, R. Sladek, Y. Bastien, J. Ho, K. Petrecca, G. Sotiropoulou, E. P. Diamandis, T. J. Hudson, and J. H. White
Expression Profiling in Squamous Carcinoma Cells Reveals Pleiotropic Effects of Vitamin D3 Analog EB1089 Signaling on Cell Proliferation, Differentiation, and Immune System Regulation
Mol. Endocrinol., June 1, 2002; 16(6): 1243 - 1256.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online