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Physiol. Rev. 78: 763-781, 1998;
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PHYSIOLOGICAL REVIEWS   Vol. 78 No. 3 July 1998, pp. 763-781
Copyright ©1998 The American Physiological Society

The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling

PAUL A. JANMEY

Experimental Medicine Division, Brigham and Women's Hospital, Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts

Janmey, Paul A. The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling. Physiol. Rev. 78: 763-781, 1998. --- The three-dimensional intracellular network formed by the filamentous polymers comprising the cytoskeletal affects the way cells sense their extracellular environment and respond to stimuli. Because the cytoskeleton is viscoelastic, it provides a continuous mechanical coupling throughout the cell that changes as the cytoskeleton remodels. Such mechanical effects, based on network formation, can influence ion channel activity at the plasma membrane of cells and may conduct mechanical stresses from the cell membrane to internal organelles. As a result, both rapid responses such as changes in intracellular Ca2+ and slower responses such as gene transcription or the onset of apoptosis can be elicited or modulated by mechanical perturbations. In addition to mechanical features, the cytoskeleton also provides a large negatively charged surface on which many signaling molecules including protein and lipid kinases, phospholipases, and GTPases localize in response to activation of specific transmembrane receptors. The resulting spatial localization and concomitant change in enzymatic activity can alter the magnitude and limit the range of intracellular signaling events.




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Mastoparan Alters Subcellular Distribution of Profilin and Remodels F-Actin Cytoskeleton in Cells of Maize Root Apices
Plant Cell Physiol., September 1, 2001; 42(9): 912 - 922.
[Abstract] [Full Text] [PDF]


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JCBHome page
W. Bloch, Y. Fan, J. Han, S. Xue, T. Schoneberg, G. Ji, Z. J. Lu, M. Walther, R. Fassler, J. Hescheler, et al.
Disruption of cytoskeletal integrity impairs Gi-mediated signaling due to displacement of Gi proteins
J. Cell Biol., August 20, 2001; 154(4): 753 - 762.
[Abstract] [Full Text] [PDF]


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GutHome page
M Tashiro, C Schafer, H Yao, S A Ernst, and J A Williams
Arginine induced acute pancreatitis alters the actin cytoskeleton and increases heat shock protein expression in rat pancreatic acinar cells
Gut, August 1, 2001; 49(2): 241 - 250.
[Abstract] [Full Text] [PDF]


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RadiologyHome page
T. Abruzzo, H. J. Cloft, G. G. Shengelaia, S. M. Waldrop, D. F. Kallmes, J. E. Dion, I. Constantinidis, and A. Sambanis
In Vitro Effects of Transcatheter Injection on Structure, Cell Viability, and Cell Metabolism in Fibroblast-impregnated Alginate Microspheres
Radiology, August 1, 2001; 220(2): 428 - 435.
[Abstract] [Full Text] [PDF]


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Cardiovasc ResHome page
P. Lacolley, P. Challande, S. Boumaza, G. Cohuet, S. Laurent, P. Boutouyrie, J.-A. Grimaud, D. Paulin, J.-M. D. Lamaziere, and Z. Li
Mechanical properties and structure of carotid arteries in mice lacking desmin
Cardiovasc Res, July 1, 2001; 51(1): 178 - 187.
[Abstract] [Full Text] [PDF]


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J. Physiol.Home page
X.-L. Chen, Z.-G. Zhong, S. Yokoyama, C. Bark, B. Meister, P.-O. Berggren, J. Roder, H. Higashida, and A. Jeromin
Overexpression of rat neuronal calcium sensor-1 in rodent NG108-15 cells enhances synapse formation and transmission
J. Physiol., May 1, 2001; 532(3): 649 - 659.
[Abstract] [Full Text] [PDF]


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J. Physiol.Home page
T. Koyama, M. Oike, and Y. Ito
Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells
J. Physiol., May 1, 2001; 532(3): 759 - 769.
[Abstract] [Full Text] [PDF]


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Cardiovasc ResHome page
D. Babuty and M. J Lab
Mechanoelectric contributions to sudden cardiac death
Cardiovasc Res, May 1, 2001; 50(2): 270 - 279.
[Full Text] [PDF]


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JBJSHome page
R. L. Vinall and A. H. Reddi
The Effect of BMP on the Expression of Cytoskeletal Proteins and Its Potential Relevance
J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S63 - 69.
[Full Text] [PDF]


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Am. J. Respir. Cell Mol. Bio.Home page
S. R. White, P. Williams, K. R. Wojcik, S. Sun, P. S. Hiemstra, K. F. Rabe, and D. R. Dorscheid
Initiation of Apoptosis by Actin Cytoskeletal Derangement in Human Airway Epithelial Cells
Am. J. Respir. Cell Mol. Biol., March 1, 2001; 24(3): 282 - 294.
[Abstract] [Full Text] [PDF]


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J. Am. Soc. Nephrol.Home page
N. ENDLICH, K. R. KRESS, J. REISER, D. UTTENWEILER, W. KRIZ, P. MUNDEL, and K. ENDLICH
Podocytes Respond to Mechanical Stress In Vitro
J. Am. Soc. Nephrol., March 1, 2001; 12(3): 413 - 422.
[Abstract] [Full Text]


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JBJSHome page
R. L. Vinall and A. H. Reddi
The Effect of BMP on the Expression of Cytoskeletal Proteins and Its Potential Relevance
J. Bone Joint Surg. Am., March 1, 2001; 83(1_suppl_1): S63 - S69.
[Full Text] [PDF]


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J. Cell Sci.Home page
N Foger, R Marhaba, and M Zoller
Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells
J. Cell Sci., January 3, 2001; 114(6): 1169 - 1178.
[Abstract] [PDF]


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J. Appl. Physiol.Home page
D. Stamenovic and N. Wang
Cellular Responses to Mechanical Stress: Invited Review: Engineering approaches to cytoskeletal mechanics
J Appl Physiol, November 1, 2000; 89(5): 2085 - 2090.
[Abstract] [Full Text] [PDF]


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J. Neurosci.Home page
H. Morihata, F. Nakamura, T. Tsutada, and M. Kuno
Potentiation of a Voltage-Gated Proton Current in Acidosis-Induced Swelling of Rat Microglia
J. Neurosci., October 1, 2000; 20(19): 7220 - 7227.
[Abstract] [Full Text] [PDF]


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Physiol. Rev.Home page
M. J. Rebecchi and S. N. Pentyala
Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C
Physiol Rev, October 1, 2000; 80(4): 1291 - 1335.
[Abstract] [Full Text] [PDF]


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Circ. Res.Home page
K. G. Franchini, A. S. Torsoni, P. H. A. Soares, and M. J. A. Saad
Early Activation of the Multicomponent Signaling Complex Associated With Focal Adhesion Kinase Induced by Pressure Overload in the Rat Heart
Circ. Res., September 29, 2000; 87(7): 558 - 565.
[Abstract] [Full Text] [PDF]


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JCBHome page
R. L. Roll, E. M. Bauman, J. S. Bennett, and C. S. Abrams
Phosphorylated Pleckstrin Induces Cell Spreading via an Integrin-Dependent Pathway
J. Cell Biol., September 18, 2000; 150(6): 1461 - 1466.
[Abstract] [Full Text] [PDF]


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JCBHome page
M. Glogauer, J. Hartwig, and T. Stossel
Two Pathways through Cdc42 Couple the N-Formyl Receptor to Actin Nucleation in Permeabilized Human Neutrophils
J. Cell Biol., August 21, 2000; 150(4): 785 - 796.
[Abstract] [Full Text] [PDF]


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J. Physiol.Home page
J Harvey, S C Hardy, A J Irving, and M L J Ashford
Leptin activation of ATP-sensitive K+ (KATP) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton
J. Physiol., August 15, 2000; 527(1): 95 - 107.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
M. Nakamura, M. Sunagawa, T. Kosugi, and N. Sperelakis
Actin filament disruption inhibits L-type Ca2+ channel current in cultured vascular smooth muscle cells
Am J Physiol Cell Physiol, August 1, 2000; 279(2): C480 - C487.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Baritussio, A. Alberti, D. Armanini, F. Meloni, and D. Bruttomesso
Different pathways of degradation of SP-A and saturated phosphatidylcholine by alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, July 1, 2000; 279(1): L91 - L99.
[Abstract] [Full Text] [PDF]


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J. Physiol.Home page
Y. G. Wang, A. M Samarel, and S. L Lipsius
Laminin acts via {beta}1 integrin signalling to alter cholinergic regulation of L-type Ca2+ current in cat atrial myocytes
J. Physiol., July 1, 2000; 526(1): 57 - 68.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. Ressler, R. T. Lee, S. H. Randell, J. M. Drazen, and R. D. Kamm
Molecular responses of rat tracheal epithelial cells to transmembrane pressure
Am J Physiol Lung Cell Mol Physiol, June 1, 2000; 278(6): L1264 - L1272.
[Abstract] [Full Text] [PDF]


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Circ. Res.Home page
B. P. Helmke, R. D. Goldman, and P. F. Davies
Rapid Displacement of Vimentin Intermediate Filaments in Living Endothelial Cells Exposed to Flow
Circ. Res., April 14, 2000; 86(7): 745 - 752.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Heart Circ. Physiol.Home page
P. He, M. Zeng, and F. E. Curry
Dominant role of cAMP in regulation of microvessel permeability
Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1124 - H1133.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Marchi, W. Liu, and V. C. Broaddus
Mesothelial cell apoptosis is confirmed in vivo by morphological change in cytokeratin distribution
Am J Physiol Lung Cell Mol Physiol, March 1, 2000; 278(3): L528 - L535.
[Abstract] [Full Text] [PDF]


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J. Cell Sci.Home page
Y Shafrir, D ben-Avraham, and G Forgacs
Trafficking and signaling through the cytoskeleton: a specific mechanism
J. Cell Sci., January 8, 2000; 113(15): 2747 - 2757.
[Abstract] [PDF]




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