Physiol Rev AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 78: 487-545, 1998;
0031-9333/98 $15.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DEVÉS, R.
Right arrow Articles by BOYD, C. A. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DEVÉS, R.
Right arrow Articles by BOYD, C. A. R.

PHYSIOLOGICAL REVIEWS   Vol. 78 No. 2 April 1998, pp. 487-545
Copyright ©1998 The American Physiological Society

Transporters for Cationic Amino Acids in Animal Cells: Discovery, Structure, and Function

R. DEVÉS AND C. A. R. BOYD

Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago, Chile; and Department of Human Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

Devés, R., and C. A. R. Boyd. Transporters for Cationic Amino Acids in Animal Cells: Discovery, Structure, and Function. Physiol. Rev. 78: 487-545, 1998. --- The structure and function of the four cationic amino acid transporters identified in animal cells are discussed. The systems differ in specificity, cation dependence, and physiological role. One of them, system y+, is selective for cationic amino acids, whereas the others (B0,+, b0,+, and y+L) also accept neutral amino acids. In recent years, cDNA clones related to these activities have been isolated. Thus two families of proteins have been identified: 1) CAT or cationic amino acid transporters and 2) BAT or broad-scope transport proteins. In the CAT family, three genes encode for four different isoforms [CAT-1, CAT-2A, CAT-2(B) and CAT-3]; these are ~70-kDa proteins with multiple transmembrane segments (-), and despite their structural similarity, they differ in tissue distribution, kinetics, and regulatory properties. System y+ is the expression of the activity of CAT transporters. The BAT family includes two isoforms (rBAT and 4F2hc); these are 59- to 78-kDa proteins with one to four membrane-spanning segments, and it has been proposed that these proteins act as transport regulators. The expression of rBAT and 4F2hc induces system b0,+ and system y+L activity in Xenopus laevis oocytes, respectively. The roles of these transporters in nutrition, endocrinology, nitric oxide biology, and immunology, as well as in the genetic diseases cystinuria and lysinuric protein intolerance, are reviewed. Experimental strategies, which can be used in the kinetic characterization of coexpressed transporters, are also discussed.




This article has been cited by other articles:


Home page
 J. Physiol.Home page
E. Tsitsiou, C. P. Sibley, S. W. D'Souza, O. Catanescu, D. W. Jacobsen, and J. D. Glazier
Homocysteine transport by systems L, A and y+L across the microvillous plasma membrane of human placenta
J. Physiol., August 15, 2009; 587(16): 4001 - 4013.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. L. Vega, C. Puebla, R. Vasquez, M. Farias, J. Alarcon, M. Pastor-Anglada, B. Krause, P. Casanello, and L. Sobrevia
TGF-{beta}1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium
Cardiovasc Res, June 1, 2009; 82(3): 458 - 467.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
K. Jager, U. Bonisch, M. Risch, D. Worlitzsch, and F. Paulsen
Detection and Regulation of Cationic Amino Acid Transporters in Healthy and Diseased Ocular Surface
Invest. Ophthalmol. Vis. Sci., March 1, 2009; 50(3): 1112 - 1121.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
S. F. Liao, E. S. Vanzant, D. L. Harmon, K. R. McLeod, J. A. Boling, and J. C. Matthews
Ruminal and abomasal starch hydrolysate infusions selectively decrease the expression of cationic amino acid transporter mRNA by small intestinal epithelia of forage-fed beef steers
J Dairy Sci, March 1, 2009; 92(3): 1124 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
Y. C. Luiking, M. M. Hallemeesch, M. C. van de Poll, C. H. C. Dejong, W. J. de Jonge, W. H. Lamers, and N. E. P. Deutz
Reduced citrulline availability by OTC deficiency in mice is related to reduced nitric oxide production
Am J Physiol Endocrinol Metab, December 1, 2008; 295(6): E1315 - E1322.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. Gerber, M. Comellas-Bigler, B. A. Goetz, and K. P. Locher
Structural Basis of Trans-Inhibition in a Molybdate/Tungstate ABC Transporter
Science, July 11, 2008; 321(5886): 246 - 250.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. R. Talukder, R. Kekuda, P. Saha, S. Arthur, and U. Sundaram
Identification and characterization of rabbit small intestinal villus cell brush border membrane Na-glutamine cotransporter
Am J Physiol Gastrointest Liver Physiol, July 1, 2008; 295(1): G7 - G15.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
S. F. Liao, E. S. Vanzant, J. A. Boling, and J. C. Matthews
Identification and expression pattern of cationic amino acid transporter-1 mRNA in small intestinal epithelia of Angus steers at four production stages
J Anim Sci, March 1, 2008; 86(3): 620 - 631.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
C. A. R. Boyd
Facts, fantasies and fun in epithelial physiology
Exp Physiol, March 1, 2008; 93(3): 303 - 314.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. Broer
Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia
Physiol Rev, January 1, 2008; 88(1): 249 - 286.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Baylis
Nitric oxide deficiency in chronic kidney disease
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F1 - F9.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Chen, C. MacLeod, B. Deng, L. Mason, M. Kasaian, S. Goldman, S. Wolf, C. Williams, and M. R. Bowman
CAT-2 amplifies the agonist-evoked force of airway smooth muscle by enhancing spermine-mediated phosphatidylinositol-(4)-phosphate-5-kinase-{gamma} activity
Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L883 - L891.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
B. M. Rotoli, V. Dall'Asta, A. Barilli, R. D'Ippolito, A. Tipa, D. Olivieri, G. C. Gazzola, and O. Bussolati
Alveolar Macrophages from Normal Subjects Lack the NOS-Related System y+ for Arginine Transport
Am. J. Respir. Cell Mol. Biol., July 1, 2007; 37(1): 105 - 112.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. M. Morris Jr.
Arginine Metabolism: Boundaries of Our Knowledge
J. Nutr., June 1, 2007; 137(6): 1602S - 1609S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Rotmann, A. Simon, U. Martine, A. Habermeier, and E. I. Closs
Activation of classical protein kinase C decreases transport via systems y+ and y+L
Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2259 - C2268.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Belforte, M. C. Moreno, C. Cymeryng, M. Bordone, M. I. Keller Sarmiento, and R. E. Rosenstein
Effect of Ocular Hypertension on Retinal Nitridergic Pathway Activity
Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2127 - 2133.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Horowitz, D. G. Binion, V. M. Nelson, Y. Kanaa, P. Javadi, Z. Lazarova, C. Andrekopoulos, B. Kalyanaraman, M. F. Otterson, and P. Rafiee
Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease
Am J Physiol Gastrointest Liver Physiol, May 1, 2007; 292(5): G1323 - G1336.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. D. Peluffo
L-Arginine currents in rat cardiac ventricular myocytes
J. Physiol., May 1, 2007; 580(3): 925 - 936.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
V. Cerec, C. Piquet-Pellorce, H. A.A. Aly, A.-M. Touzalin, B. Jegou, and F. Bauche
Multiple Pathways for Cationic Amino Acid Transport in Rat Seminiferous Tubule Cells
Biol Reprod, February 1, 2007; 76(2): 241 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. M.C. Brunini, A. C. Mendes-Ribeiro, J. C. Ellory, and G. E. Mann
Platelet nitric oxide synthesis in uremia and malnutrition: A role for L-arginine supplementation in vascular protection?
Cardiovasc Res, January 15, 2007; 73(2): 359 - 367.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. L. Seymour, V. Ganapathy, A. L. Mellor, and D. H. Munn
A high-affinity, tryptophan-selective amino acid transport system in human macrophages
J. Leukoc. Biol., December 1, 2006; 80(6): 1320 - 1327.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. R. Queen, Y. Ji, B. Xu, L. Young, K. Yao, A. W. Wyatt, D. J. Rowlands, R. C. M. Siow, G. E. Mann, and A. Ferro
Mechanisms underlying {beta}2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells
J. Physiol., October 15, 2006; 576(2): 585 - 594.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
G. M. Attardo, I. A. Hansen, S.-H. Shiao, and A. S. Raikhel
Identification of two cationic amino acid transporters required for nutritional signaling during mosquito reproduction
J. Exp. Biol., August 15, 2006; 209(16): 3071 - 3078.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. M. Repetto, V. Pannunzio, F. Astort, C. Martinez Calejman, M. B. Moreno, O. P. Pignataro, and C. B. Cymeryng
Characterization of L-arginine transport in adrenal cells: effect of ACTH
Am J Physiol Endocrinol Metab, August 1, 2006; 291(2): E291 - E297.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. L. O'Kane, J. R. Vina, I. Simpson, R. Zaragoza, A. Mokashi, and R. A. Hawkins
Cationic amino acid transport across the blood-brain barrier is mediated exclusively by system y+
Am J Physiol Endocrinol Metab, August 1, 2006; 291(2): E412 - E419.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Kakoki, H.-S. Kim, C.-J. S. Edgell, N. Maeda, O. Smithies, and D. L. Mattson
Amino acids as modulators of endothelium-derived nitric oxide
Am J Physiol Renal Physiol, August 1, 2006; 291(2): F297 - F304.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
M. T. Talaue, V. Venketaraman, M. H. Hazbon, M. Peteroy-Kelly, A. Seth, R. Colangeli, D. Alland, and N. D. Connell
Arginine Homeostasis in J774.1 Macrophages in the Context of Mycobacterium bovis BCG Infection
J. Bacteriol., July 1, 2006; 188(13): 4830 - 4840.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Kato, T. Maeda, T. Akaike, and I. Tamai
Characterization of novel Na+-dependent nucleobase transport systems at the blood-testis barrier
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E968 - E975.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. Martin, M. Comalada, L. Marti, E. I. Closs, C. L. MacLeod, R. Martin del Rio, A. Zorzano, M. Modolell, A. Celada, M. Palacin, et al.
Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages
Am J Physiol Cell Physiol, May 1, 2006; 290(5): C1364 - C1372.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Shima, T. Maeda, S. Aizawa, I. Tsuboi, D. Kobayashi, R. Kato, and I. Tamai
L-arginine import via cationic amino acid transporter CAT1 is essential for both differentiation and proliferation of erythrocytes
Blood, February 15, 2006; 107(4): 1352 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
N. McCord, P. Ayuk, M. McMahon, R. C.A. Boyd, I. Sargent, and C. Redman
System y+ Arginine Transport and NO Production in Peripheral Blood Mononuclear Cells in Pregnancy and Preeclampsia
Hypertension, January 1, 2006; 47(1): 109 - 115.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. Casanello, A. Torres, F. Sanhueza, M. Gonzalez, M. Farias, V. Gallardo, M. Pastor-Anglada, R. S. Martin, and L. Sobrevia
Equilibrative Nucleoside Transporter 1 Expression Is Downregulated by Hypoxia in Human Umbilical Vein Endothelium
Circ. Res., July 8, 2005; 97(1): 16 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. T. Solbu, J.-L. Boulland, W. Zahid, M. K. Lyamouri Bredahl, M. Amiry-Moghaddam, J. Storm-Mathisen, B. A. Roberg, and F. A. Chaudhry
Induction and Targeting of the Glutamine Transporter SN1 to the Basolateral Membranes of Cortical Kidney Tubule Cells during Chronic Metabolic Acidosis Suggest a Role in pH Regulation
J. Am. Soc. Nephrol., April 1, 2005; 16(4): 869 - 877.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Verri, C. Dimitri, S. Treglia, F. Storelli, S. De Micheli, L. Ulianich, P. Vito, S. Marsigliante, C. Storelli, and B. Di Jeso
Multiple pathways for cationic amino acid transport in rat thyroid epithelial cell line PC Cl3
Am J Physiol Cell Physiol, February 1, 2005; 288(2): C290 - C303.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Kakoki, H.-S. Kim, W. J. Arendshorst, and D. L. Mattson
L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1478 - R1485.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
E. I. Closs, A. Simon, N. Vekony, and A. Rotmann
Plasma Membrane Transporters for Arginine
J. Nutr., October 1, 2004; 134(10): 2752S - 2759S.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
D. G. Romero, M. Plonczynski, G. R. Vergara, E. P. Gomez-Sanchez, and C. E. Gomez-Sanchez
Angiotensin II early regulated genes in H295R human adrenocortical cells
Physiol Genomics, September 16, 2004; 19(1): 106 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. L. M. Ricciardolo, P. J. Sterk, B. Gaston, and G. Folkerts
Nitric Oxide in Health and Disease of the Respiratory System
Physiol Rev, July 1, 2004; 84(3): 731 - 765.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. G. Chicoine, M. L. Paffett, T. L. Young, and L. D. Nelin
Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L60 - L68.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. I. Zharikov, K. Y. Krotova, L. Belayev, and E. R. Block
Pertussis toxin activates L-arginine uptake in pulmonary endothelial cells through downregulation of PKC-{alpha} activity
Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L974 - L983.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. F. Speake, J. D. Glazier, P. T.-Y. Ayuk, M. Reade, C. P. Sibley, and S. W. D'Souza
L-Arginine Transport across the Basal Plasma Membrane of the Syncytiotrophoblast of the Human Placenta from Normal and Preeclamptic Pregnancies
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4287 - 4292.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
B. Jain-Vakkalagadda, S. Dey, D. Pal, and A. K. Mitra
Identification and Functional Characterization of a Na+-Independent Large Neutral Amino Acid Transporter, LAT1, in Human and Rabbit Cornea
Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 2919 - 2927.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Y. Krotova, S. I. Zharikov, and E. R. Block
Classical isoforms of PKC as regulators of CAT-1 transporter activity in pulmonary artery endothelial cells
Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L1037 - L1044.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Habermeier, S. Wolf, U. Martine, P. Graf, and E. I. Closs
Two Amino Acid Residues Determine the Low Substrate Affinity of Human Cationic Amino Acid Transporter-2A
J. Biol. Chem., May 23, 2003; 278(21): 19492 - 19499.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. Ortiz, B. A. Stoos, N. J. Hong, D. M. Boesch, C. F. Plato, and J. L. Garvin
High-Salt Diet Increases Sensitivity to NO and eNOS Expression But Not NO Production in THALs
Hypertension, March 1, 2003; 41(3): 682 - 687.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Flores, S. Rojas, C. Aguayo, J. Parodi, G. Mann, J. D. Pearson, P. Casanello, and L. Sobrevia
Rapid Stimulation of L-Arginine Transport by D-Glucose Involves p42/44mapk and Nitric Oxide in Human Umbilical Vein Endothelium
Circ. Res., January 10, 2003; 92(1): 64 - 72.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Bauch, N. Forster, D. Loffing-Cueni, V. Summa, and F. Verrey
Functional Cooperation of Epithelial Heteromeric Amino Acid Transporters Expressed in Madin-Darby Canine Kidney Cells
J. Biol. Chem., January 3, 2003; 278(2): 1316 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
G. E. Mann, D. L. Yudilevich, and L. Sobrevia
Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells
Physiol Rev, January 1, 2003; 83(1): 183 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
K. Kizhatil and L. M. Albritton
System y+ localizes to different membrane subdomains in the basolateral plasma membrane of epithelial cells
Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1784 - C1794.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Wagner, J. D. Klein, J. M. Sands, and C. Baylis
Urea transporters are distributed in endothelial cells and mediate inhibition of L-arginine transport
Am J Physiol Renal Physiol, September 1, 2002; 283(3): F578 - F582.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Vega-Agapito, A. Almeida, M. Hatzoglou, and J. P. Bolanos
Peroxynitrite Stimulates L-Arginine Transport System y+ in Glial Cells. A POTENTIAL MECHANISM FOR REPLENISHING NEURONAL L-ARGININE
J. Biol. Chem., August 9, 2002; 277(33): 29753 - 29759.
[Abstract] [Full Text] [PDF]

Home page
 Vasc MedHome page
R. Maas, E. Schwedhelm, J. Albsmeier, and R. H Boger
The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function
Vascular Medicine, August 1, 2002; 7(3): 213 - 225.
[Abstract] [PDF]

Home page
 Circ. Res.Home page
P. Casanello and L. Sobrevia
Intrauterine Growth Retardation Is Associated With Reduced Activity and Expression of the Cationic Amino Acid Transport Systems y+/hCAT-1 and y+/hCAT-2B and Lower Activity of Nitric Oxide Synthase in Human Umbilical Vein Endothelial Cells
Circ. Res., July 26, 2002; 91(2): 127 - 134.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. A. Sanchez, R. Tryon, J. Green, I. Boor, and S. M. Landfear
Six Related Nucleoside/Nucleobase Transporters from Trypanosoma brucei Exhibit Distinct Biochemical Functions
J. Biol. Chem., June 7, 2002; 277(24): 21499 - 21504.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. Kakoki, W. Wang, and D. L. Mattson
Cationic Amino Acid Transport in the Renal Medulla and Blood Pressure Regulation
Hypertension, February 1, 2002; 39(2): 287 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. Sala, B. M. Rotoli, E. Colla, R. Visigalli, A. Parolari, O. Bussolati, G. C. Gazzola, and V. Dall'Asta
Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y+
Am J Physiol Cell Physiol, January 1, 2002; 282(1): C134 - C143.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
C. E. P. de Figueiredo, B. E. P. da Costa, L. Comerlato, E. Micheli, and E. Barros
Low dose L-arginine reduces blood pressure and endothelin-1 production in hypertensive uraemic rats
Nephrol. Dial. Transplant., October 1, 2001; 16(10): 2110 - 2111.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. A. Wagner, F. Lang, and S. Broer
Function and structure of heterodimeric amino acid transporters
Am J Physiol Cell Physiol, October 1, 2001; 281(4): C1077 - C1093.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. K. Kiemer and A. M. Vollmar
Induction of L-Arginine Transport Is Inhibited by Atrial Natriuretic Peptide: A Peptide Hormone as a Novel Regulator of Inducible Nitric-Oxide Synthase Substrate Availability
Mol. Pharmacol., September 1, 2001; 60(3): 421 - 426.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
N. E. Avissar, C. K. Ryan, V. Ganapathy, and H. C. Sax
Na+-dependent neutral amino acid transporter ATB0 is a rabbit epithelial cell brush-border protein
Am J Physiol Cell Physiol, September 1, 2001; 281(3): C963 - C971.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
V. T. Cannon, R. K. Zalups, and D. W. Barfuss
Amino Acid Transporters Involved in Luminal Transport of Mercuric Conjugates of Cysteine in Rabbit Proximal Tubule
J. Pharmacol. Exp. Ther., August 1, 2001; 298(2): 780 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Xiao, L. Wagner, J. Mahaney, and C. Baylis
Uremic levels of urea inhibit L-arginine transport in cultured endothelial cells
Am J Physiol Renal Physiol, June 1, 2001; 280(6): F989 - F995.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
R. Hammermann, M. D. M. Dreißig, J. Mössner, M. Fuhrmann, L. Berrino, M. Göthert, and K. Racké
Nuclear Factor-kappa B Mediates Simultaneous Induction of Inducible Nitric-Oxide Synthase and Up-Regulation of the Cationic Amino Acid Transporter CAT-2B in Rat Alveolar Macrophages
Mol. Pharmacol., April 13, 2001; 58(6): 1294 - 1302.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Kitiyakara, T. Chabrashvili, P. Jose, W. J. Welch, and C. S. Wilcox
Effects of dietary salt intake on plasma arginine
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1069 - R1075.
[Abstract] [Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
N. E. Avissar, T. R. Ziegler, H. T. Wang, L. H. Gu, J.-n. H. Miller, P. Iannoli, F. H. Leibach, V. Ganapathy, and H. C. Sax
Growth Factors Regulation of Rabbit Sodium-Dependent Neutral Amino Acid Transporter ATB0 and Oligopeptide Transporter 1 mRNAs Expression after Enterectomy
JPEN J Parenter Enteral Nutr, March 1, 2001; 25(2): 65 - 72.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. I. Zharikov, A. A. Sigova, S. Chen, M. R. Bubb, and E. R. Block
Cytoskeletal regulation of the L-arginine/NO pathway in pulmonary artery endothelial cells
Am J Physiol Lung Cell Mol Physiol, March 1, 2001; 280(3): L465 - L473.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A.C. Mendes Ribeiro, T.M.C. Brunini, J.C. Ellory, and G.E. Mann
Abnormalities in L-arginine transport and nitric oxide biosynthesis in chronic renal and heart failure
Cardiovasc Res, March 1, 2001; 49(4): 697 - 712.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
V. Dall'Asta, O. Bussolati, R. Sala, B. M. Rotoli, G. Sebastio, M. P. Sperandeo, G. Andria, and G. C. Gazzola
Arginine transport through system y+L in cultured human fibroblasts: normal phenotype of cells from LPI subjects
Am J Physiol Cell Physiol, December 1, 2000; 279(6): C1829 - C1837.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Nawrath, J. W. Wegener, J. Rupp, A. Habermeier, and E. I. Closs
Voltage dependence of L-arginine transport by hCAT-2A and hCAT-2B expressed in oocytes from Xenopus laevis
Am J Physiol Cell Physiol, November 1, 2000; 279(5): C1336 - C1344.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
D. L. Jack, I. T. Paulsen, and M. H. Saier
The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations
Microbiology, August 1, 2000; 146(8): 1797 - 1814.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. T.-Y. Ayuk, C. P. Sibley, P. Donnai, S. D'Souza, and J. D. Glazier
Development and polarization of cationic amino acid transporters and regulators in the human placenta
Am J Physiol Cell Physiol, June 1, 2000; 278(6): C1162 - C1171.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. Wu, B. Cholewa, and D. L. Mattson
Characterization of L-arginine transporters in rat renal inner medullary collecting duct
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1506 - R1512.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Gloy, S. Reitinger, K.-G. Fischer, R. Schreiber, A. Boucherot, K. Kunzelmann, P. Mundel, and H. Pavenstadt
Amino acid transport in podocytes
Am J Physiol Renal Physiol, June 1, 2000; 278(6): F999 - F1005.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. P. Rajan, W. Huang, R. Kekuda, R. L. George, J. Wang, S. J. Conway, L. D. Devoe, F. H. Leibach, P. D. Prasad, and V. Ganapathy
Differential Influence of the 4F2 Heavy Chain and the Protein Related to b0,+ Amino Acid Transport on Substrate Affinity of the Heteromeric b0,+ Amino Acid Transporter
J. Biol. Chem., May 5, 2000; 275(19): 14331 - 14335.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. Mykkanen, D. Torrents, M. Pineda, M. Camps, M. E. Yoldi, N. Horelli-Kuitunen, K. Huoponen, M. Heinonen, J. Oksanen, O. Simell, et al.
Functional analysis of novel mutations in y+LAT-1 amino acid transporter gene causing lysinuric protein intolerance (LPI)
Hum. Mol. Genet., February 12, 2000; 9(3): 431 - 438.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
E. I. Closs, J.-S. Scheld, M. Sharafi, and U. Förstermann
Substrate Supply for Nitric-Oxide Synthase in Macrophages and Endothelial Cells: Role of Cationic Amino Acid Transporters
Mol. Pharmacol., January 1, 2000; 57(1): 68 - 74.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. A. Ogonowski, W. H. Kaesemeyer, L. Jin, V. Ganapathy, F. H. Leibach, and R. W. Caldwell
Effects of NO donors and synthase agonists on endothelial cell uptake of L-Arg and superoxide production
Am J Physiol Cell Physiol, January 1, 2000; 278(1): C136 - C143.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. D. Walters, F. Zhang, and R. J. Nakkula
Mechanisms of Fluoroquinolone Transport by Human Neutrophils
Antimicrob. Agents Chemother., November 1, 1999; 43(11): 2710 - 2715.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
D. P. Rajan, R. Kekuda, W. Huang, H. Wang, L. D. Devoe, F. H. Leibach, P. D. Prasad, and V. Ganapathy
Cloning and Expression of a b0,+-like Amino Acid Transporter Functioning as a Heterodimer with 4F2hc Instead of rBAT. A NEW CANDIDATE GENE FOR CYSTINURIA
J. Biol. Chem., October 8, 1999; 274(41): 29005 - 29010.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. L. Sloan and S. Mager
Cloning and Functional Expression of a Human Na+ and Cl--dependent Neutral and Cationic Amino Acid Transporter B0+
J. Biol. Chem., August 20, 1999; 274(34): 23740 - 23745.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Pineda, E. Fernandez, D. Torrents, R. Estevez, C. Lopez, M. Camps, J. Lloberas, A. Zorzano, and M. Palacin
Identification of a Membrane Protein, LAT-2, That Co-expresses with 4F2 Heavy Chain, an L-type Amino Acid Transport Activity with Broad Specificity for Small and Large Zwitterionic Amino Acids
J. Biol. Chem., July 9, 1999; 274(28): 19738 - 19744.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. B. Cymeryng, L. A. Dada, C. Colonna, C. F. Mendez, and E. J. Podestá
Effects of L-Arginine in Rat Adrenal Cells: Involvement of Nitric Oxide Synthase
Endocrinology, July 1, 1999; 140(7): 2962 - 2967.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
V. L. Tlapak-Simmons, B. A. Baggenstoss, T. Clyne, and P. H. Weigel
Purification and Lipid Dependence of the Recombinant Hyaluronan Synthases from Streptococcus pyogenes and Streptococcus equisimilis
J. Biol. Chem., February 12, 1999; 274(7): 4239 - 4245.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G A Barker, R J Wilkins, S Golding, and J C Ellory
Neutral amino acid transport in bovine articular chondrocytes
J. Physiol., February 1, 1999; 514(3): 795 - 808.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Torrents, R. Estevez, M. Pineda, E. Fernandez, J. Lloberas, Y.-B. Shi, A. Zorzano, and M. Palacin
Identification and Characterization of a Membrane Protein (y+L Amino Acid Transporter-1) That Associates with 4F2hc to Encode the Amino Acid Transport Activity y+L. A CANDIDATE GENE FOR LYSINURIC PROTEIN INTOLERANCE
J. Biol. Chem., December 4, 1998; 273(49): 32437 - 32445.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. PALACIN, R. ESTEVEZ, J. BERTRAN, and A. ZORZANO
Molecular Biology of Mammalian Plasma Membrane Amino Acid Transporters
Physiol Rev, October 1, 1998; 78(4): 969 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Kanai, Y. Fukasawa, S. H. Cha, H. Segawa, A. Chairoungdua, D. K. Kim, H. Matsuo, J. Y. Kim, K.-i. Miyamoto, E. Takeda, et al.
Transport Properties of a System y+L Neutral and Basic Amino Acid Transporter. INSIGHTS INTO THE MECHANISMS OF SUBSTRATE RECOGNITION
J. Biol. Chem., June 30, 2000; 275(27): 20787 - 20793.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Nicholson, C. K. Manner, J. Kleeman, and C. L. MacLeod
Sustained Nitric Oxide Production in Macrophages Requires the Arginine Transporter CAT2
J. Biol. Chem., May 4, 2001; 276(19): 15881 - 15885.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Llull, E. Garcia, and R. Lopez
Tts, a Processive beta -Glucosyltransferase of Streptococcus pneumoniae, Directs the Synthesis of the Branched Type 37 Capsular Polysaccharide in Pneumococcus and Other Gram-positive Species
J. Biol. Chem., June 8, 2001; 276(24): 21053 - 21061.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online