Physiol Rev Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


Physiol. Rev. 78: 247-306, 1998;
0031-9333/98 $15.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LANG, F.
Right arrow Articles by HÄUSSINGER, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LANG, F.
Right arrow Articles by HÄUSSINGER, D.

PHYSIOLOGICAL REVIEWS   Vol. 78 No. 1 January 1998, pp. 247-306
Copyright ©1998 The American Physiological Society

Functional Significance of Cell Volume Regulatory Mechanisms

FLORIAN LANG, GILLIAN L. BUSCH, MARKUS RITTER, HARALD VÖLKL, SIEGFRIED WALDEGGER, ERICH GULBINS, AND DIETER HÄUSSINGER

Institute of Physiology, University of Tübingen, Tübingen; Department of Internal Medicine, University of Düsseldorf, Düsseldorf, Germany; and Department of Internal Medicine and Institute of Physiology, University of Innsbruck, Innsbruck, Austria

Lang, Florian, Gillian L. Busch, Markus Ritter, Harald Völkl, Siegfried Waldegger, Erich Gulbins, and Dieter Häussinger. Functional Significance of Cell Volume Regulatory Mechanisms. Physiol. Rev. 78: 247-306, 1998. --- To survive, cells have to avoid excessive alterations of cell volume that jeopardize structural integrity and constancy of intracellular milieu. The function of cellular proteins seems specifically sensitive to dilution and concentration, determining the extent of macromolecular crowding. Even at constant extracellular osmolarity, volume constancy of any mammalian cell is permanently challenged by transport of osmotically active substances across the cell membrane and formation or disappearance of cellular osmolarity by metabolism. Thus cell volume constancy requires the continued operation of cell volume regulatory mechanisms, including ion transport across the cell membrane as well as accumulation or disposal of organic osmolytes and metabolites. The various cell volume regulatory mechanisms are triggered by a multitude of intracellular signaling events including alterations of cell membrane potential and of intracellular ion composition, various second messenger cascades, phosphorylation of diverse target proteins, and altered gene expression. Hormones and mediators have been shown to exploit the volume regulatory machinery to exert their effects. Thus cell volume may be considered a second message in the transmission of hormonal signals. Accordingly, alterations of cell volume and volume regulatory mechanisms participate in a wide variety of cellular functions including epithelial transport, metabolism, excitation, hormone release, migration, cell proliferation, and cell death.




This article has been cited by other articles:


Home page
Am. J. Physiol. Cell Physiol.Home page
J. Jorgacevski, M. Stenovec, M. Kreft, A. Bajic, B. Rituper, N. Vardjan, S. Stojilkovic, and R. Zorec
Hypotonicity and peptide discharge from a single vesicle
Am J Physiol Cell Physiol, September 1, 2008; 295(3): C624 - C631.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
J. R. Schelling and B. G. Abu Jawdeh
Regulation of cell survival by Na+/H+ exchanger-1
Am J Physiol Renal Physiol, September 1, 2008; 295(3): F625 - F632.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
D. Heitzmann and R. Warth
Physiology and Pathophysiology of Potassium Channels in Gastrointestinal Epithelia
Physiol Rev, July 1, 2008; 88(3): 1119 - 1182.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
Y. Jing, J. A. Dowdy, M. R. Van Scott, and J. S. Fedan
Hyperosmolarity-Induced Dilation and Epithelial Bioelectric Responses of Guinea Pig Trachea in Vitro: Role of Kinase Signaling
J. Pharmacol. Exp. Ther., July 1, 2008; 326(1): 186 - 195.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
W. K. F. Tse, S. C. Chow, and C. K. C. Wong
The cloning of eel osmotic stress transcription factor and the regulation of its expression in primary gill cell culture
J. Exp. Biol., June 15, 2008; 211(12): 1964 - 1968.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
E. Shumilina, R. S. Lam, F. Wolbing, N. Matzner, I. M. Zemtsova, M. Sobiesiak, H. Mahmud, U. Sausbier, T. Biedermann, P. Ruth, et al.
Blunted IgE-Mediated Activation of Mast Cells in Mice Lacking the Ca2+-Activated K+ Channel KCa3.1
J. Immunol., June 15, 2008; 180(12): 8040 - 8047.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
V. Kiedaisch, A. Akel, O. M Niemoeller, T. Wieder, and F. Lang
Zinc-induced suicidal erythrocyte death
Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1530 - 1534.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
H. C. Hartzell, Z. Qu, K. Yu, Q. Xiao, and L.-T. Chien
Molecular Physiology of Bestrophins: Multifunctional Membrane Proteins Linked to Best Disease and Other Retinopathies
Physiol Rev, April 1, 2008; 88(2): 639 - 672.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
F. Martinez-Pastor, E. Cabrita, F. Soares, L. Anel, and M. T. Dinis
Multivariate cluster analysis to study motility activation of Solea senegalensis spermatozoa: a model for marine teleosts
Reproduction, April 1, 2008; 135(4): 449 - 459.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
M.-B. Nielsen, S. T. Christensen, and E. K. Hoffmann
Effects of osmotic stress on the activity of MAPKs and PDGFR-{beta}-mediated signal transduction in NIH-3T3 fibroblasts
Am J Physiol Cell Physiol, April 1, 2008; 294(4): C1046 - C1055.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
V. Nechyporuk-Zloy, P. Dieterich, H. Oberleithner, C. Stock, and A. Schwab
Dynamics of single potassium channel proteins in the plasma membrane of migrating cells
Am J Physiol Cell Physiol, April 1, 2008; 294(4): C1096 - C1102.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
L. Lizana, B. Bauer, and O. Orwar
Controlling the rates of biochemical reactions and signaling networks by shape and volume changes
PNAS, March 18, 2008; 105(11): 4099 - 4104.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
P. K. Lauf, S. Misri, A. A. Chimote, and N. C. Adragna
Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cells
Am J Physiol Cell Physiol, March 1, 2008; 294(3): C820 - C832.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
P. Coulon, H.-J. Wusten, P. Hochstrate, and P. W. Dierkes
Swelling-activated chloride channels in leech Retzius neurons
J. Exp. Biol., February 15, 2008; 211(4): 630 - 641.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. E. Pafundo, O. Chara, M. P. Faillace, G. Krumschnabel, and P. J. Schwarzbaum
Kinetics of ATP release and cell volume regulation of hyposmotically challenged goldfish hepatocytes
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R220 - R233.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
C. W. McLaughlin, S. Zellhuber-McMillan, A. D. C. Macknight, and M. M. Civan
Electron microprobe analysis of rabbit ciliary epithelium indicates enhanced secretion posteriorly and enhanced absorption anteriorly
Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1455 - C1466.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
J. B. Kelley and B. M. Paschal
Hyperosmotic Stress Signaling to the Nucleus Disrupts the Ran Gradient and the Production of RanGTP
Mol. Biol. Cell, November 1, 2007; 18(11): 4365 - 4376.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Physiol.Home page
L.-T. Chien and H. C. Hartzell
Drosophila Bestrophin-1 Chloride Current Is Dually Regulated by Calcium and Cell Volume
J. Gen. Physiol., October 29, 2007; 130(5): 513 - 524.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. Sjostrom, K. Stenstrom, K. Eneling, J. Zwiller, A. I. Katz, H. Takemori, and A. M. Bertorello
SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process
PNAS, October 23, 2007; 104(43): 16922 - 16927.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
F. Lang, V. Vallon, M. Knipper, and P. Wangemann
Functional significance of channels and transporters expressed in the inner ear and kidney
Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1187 - C1208.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Coll. Nutr.Home page
F. Lang
Mechanisms and Significance of Cell Volume Regulation
J. Am. Coll. Nutr., October 1, 2007; 26(suppl_5): 613S - 623S.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
N. Rockel, C. Esser, S. Grether-Beck, U. Warskulat, U. Flogel, A. Schwarz, T. Schwarz, D. Yarosh, D. Haussinger, and J. Krutmann
The Osmolyte Taurine Protects against Ultraviolet B Radiation-Induced Immunosuppression
J. Immunol., September 15, 2007; 179(6): 3604 - 3612.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
B. L. vanTol, S. Missan, J. Crack, S. Moser, W. H. Baldridge, P. Linsdell, and E. A. Cowley
Contribution of KCNQ1 to the regulatory volume decrease in the human mammary epithelial cell line MCF-7
Am J Physiol Cell Physiol, September 1, 2007; 293(3): C1010 - C1019.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
M. Boschmann, J. Steiniger, G. Franke, A. L. Birkenfeld, F. C. Luft, and J. Jordan
Water Drinking Induces Thermogenesis through Osmosensitive Mechanisms
J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3334 - 3337.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Coll. Nutr.Home page
M. Boschmann and F. Thielecke
The Effects of Epigallocatechin-3-Gallate on Thermogenesis and Fat Oxidation in Obese Men: A Pilot Study
J. Am. Coll. Nutr., August 1, 2007; 26(4): 389S - 395S.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
B. F. Bessac and A. Fleig
TRPM7 channel is sensitive to osmotic gradients in human kidney cells
J. Physiol., August 1, 2007; 582(3): 1073 - 1086.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
D. K. Nielsen, A. K. Jensen, H. Harbak, S. C. Christensen, and L. O. Simonsen
Cell content of phosphatidylinositol (4,5)bisphosphate in Ehrlich mouse ascites tumour cells in response to cell volume perturbations in anisotonic and in isosmotic media
J. Physiol., August 1, 2007; 582(3): 1027 - 1036.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
A M Petrunkina, D Waberski, A R Gunzel-Apel, and E Topfer-Petersen
Determinants of sperm quality and fertility in domestic species
Reproduction, July 1, 2007; 134(1): 3 - 17.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
W. K. F. Tse, D. W. T. Au, and C. K. C. Wong
Effect of osmotic shrinkage and hormones on the expression of Na+/H+ exchanger-1, Na+/K+/2Cl- cotransporter and Na+/K+-ATPase in gill pavement cells of freshwater adapted Japanese eel, Anguilla japonica
J. Exp. Biol., June 15, 2007; 210(12): 2113 - 2120.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
K. Strange
Revisiting the Krogh Principle in the post-genome era: Caenorhabditis elegans as a model system for integrative physiology research
J. Exp. Biol., May 1, 2007; 210(9): 1622 - 1631.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Antolic, R. Harrison, C. Farlinger, N. M. Cermak, S. J. Peters, P. LeBlanc, and B. D. Roy
Effect of extracellular osmolality on cell volume and resting metabolism in mammalian skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1994 - R2000.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
F. Kamachi, H. S. Ban, N. Hirasawa, and K. Ohuchi
Inhibition of Lipopolysaccharide-Induced Prostaglandin E2 Production and Inflammation by the Na+/H+ Exchanger Inhibitors
J. Pharmacol. Exp. Ther., April 1, 2007; 321(1): 345 - 352.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
G. Tamma, G. Procino, M. Svelto, and G. Valenti
Hypotonicity causes actin reorganization and recruitment of the actin-binding ERM protein moesin in membrane protrusions in collecting duct principal cells
Am J Physiol Cell Physiol, April 1, 2007; 292(4): C1476 - C1484.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Schafer, L. Hoffmann, K. Heldt, M. R. Lornejad-Schafer, G. Brauers, T. Gehrmann, T. A. Garrow, D. Haussinger, E. Mayatepek, B. C. Schwahn, et al.
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells
Am J Physiol Gastrointest Liver Physiol, April 1, 2007; 292(4): G1089 - G1098.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
O. Bachmann, A. Heinzmann, A. Mack, M. P. Manns, and U. Seidler
Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells
Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G711 - G717.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
A M Petrunkina, R A P Harrison, M Tsolova, E Jebe, and E Topfer-Petersen
Signalling pathways involved in the control of sperm cell volume
Reproduction, January 1, 2007; 133(1): 61 - 73.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
T. Numata, T. Shimizu, and Y. Okada
TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells
Am J Physiol Cell Physiol, January 1, 2007; 292(1): C460 - C467.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
M. Takii, T. Ishikawa, H. Tsuda, K. Kanatani, T. Sunouchi, Y. Kaneko, and K. Nakayama
Involvement of stretch-activated cation channels in hypotonically induced insulin secretion in rat pancreatic beta-cells
Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1405 - C1411.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
S. F. Pedersen, K. A. Poulsen, and I. H. Lambert
Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts
Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1286 - C1296.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
T. Klein, T.G. Cooper, and C.H. Yeung
The Role of Potassium Chloride Cotransporters in Murine and Human Sperm Volume Regulation
Biol Reprod, December 1, 2006; 75(6): 853 - 858.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
R. Rexhepaj, F. Grahammer, H. Volkl, C. Remy, C. A. Wagner, D. Sandulache, F. Artunc, G. Henke, S. Nammi, G. Capasso, et al.
Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice
FASEB J, November 1, 2006; 20(13): 2214 - 2222.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
A. M. Heacock, D. J. Foster, and S. K. Fisher
Prostanoid Receptors Regulate the Volume-Sensitive Efflux of Osmolytes from Murine Fibroblasts via a Cyclic AMP-Dependent Mechanism
J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 963 - 971.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
C. M. McNicholas-Bevensee, K. B. DeAndrade, W. E. Bradley, L. J. Dell'Italia, P. A. Lucchesi, and M. O. Bevensee
Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure
Cardiovasc Res, November 1, 2006; 72(2): 262 - 270.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
F. Lang, C. Bohmer, M. Palmada, G. Seebohm, N. Strutz-Seebohm, and V. Vallon
(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms.
Physiol Rev, October 1, 2006; 86(4): 1151 - 1178.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
R. Reinehr, S. Becker, J. Braun, A. Eberle, S. Grether-Beck, and D. Haussinger
Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis
J. Biol. Chem., August 11, 2006; 281(32): 23150 - 23166.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
S. A. Kempson, J. M. Edwards, and M. Sturek
Inhibition of the renal betaine transporter by calcium ions
Am J Physiol Renal Physiol, August 1, 2006; 291(2): F305 - F313.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
A. P. Minton
How can biochemical reactions within cells differ from those in test tubes?
J. Cell Sci., July 15, 2006; 119(14): 2863 - 2869.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
E. C. Aromataris, M. L. Roberts, G. J. Barritt, and G. Y. Rychkov
Glucagon activates Ca2+ and Cl- channels in rat hepatocytes
J. Physiol., June 15, 2006; 573(3): 611 - 625.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
J. A. Usher-Smith, J. A. Fraser, P. S. J. Bailey, J. L. Griffin, and C. L.-H. Huang
The influence of intracellular lactate and H+ on cell volume in amphibian skeletal muscle
J. Physiol., June 15, 2006; 573(3): 799 - 818.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
A. M. Heacock, M. S. Dodd, and S. K. Fisher
Regulation of Volume-Sensitive Osmolyte Efflux from Human SH-SY5Y Neuroblastoma Cells following Activation of Lysophospholipid Receptors
J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 685 - 693.
[Abstract] [Full Text] [PDF]


Home page
Protein Sci.Home page
A. J. Beevers and A. Kukol
Secondary structure, orientation, and oligomerization of phospholemman, a cardiac transmembrane protein
Protein Sci., May 1, 2006; 15(5): 1127 - 1132.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
I. F. Abdullaev, A. Rudkouskaya, G. P. Schools, H. K. Kimelberg, and A. A. Mongin
Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes
J. Physiol., May 1, 2006; 572(3): 677 - 689.
[Abstract] [Full Text] [PDF]


Home page
Exp PhysiolHome page
U. Lodemann and H. Martens
Effects of diet and osmotic pressure on Na+ transport and tissue conductance of sheep isolated rumen epithelium
Exp Physiol, May 1, 2006; 91(3): 539 - 550.
[Abstract] [Full Text] [PDF]


Home page
Mol. Endocrinol.Home page
N.-A. Liu, Q. Liu, K. Wawrowsky, Z. Yang, S. Lin, and S. Melmed
Prolactin Receptor Signaling Mediates the Osmotic Response of Embryonic Zebrafish Lactotrophs
Mol. Endocrinol., April 1, 2006; 20(4): 871 - 880.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
A. Kurtz and F. Schweda
Osmolarity-induced renin secretion from kidneys: evidence for readily releasable renin pools
Am J Physiol Renal Physiol, April 1, 2006; 290(4): F797 - F805.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
S. Sanchez-Armass, S. R. Sennoune, D. Maiti, F. Ortega, and R. Martinez-Zaguilan
Spectral imaging microscopy demonstrates cytoplasmic pH oscillations in glial cells
Am J Physiol Cell Physiol, February 1, 2006; 290(2): C524 - C538.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
S. Ben-Tabou De-Leon, G. Ben-Zeev, and I. Nussinovitch
Effects of osmotic shrinkage on voltage-gated Ca2+ channel currents in rat anterior pituitary cells
Am J Physiol Cell Physiol, January 1, 2006; 290(1): C222 - C232.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Physiol.Home page
V. Lyall, H. Pasley, T.-H. T. Phan, S. Mummalaneni, G. L. Heck, A. K. Vinnikova, and J. A. DeSimone
Intracellular pH Modulates Taste Receptor Cell Volume and the Phasic Part of the Chorda Tympani Response to Acids
J. Gen. Physiol., December 27, 2005; 127(1): 15 - 34.
[Abstract] [Full Text] [PDF]


Home page
Mol Hum ReprodHome page
J.P. Barfield, C.H. Yeung, and T.G. Cooper
Characterization of potassium channels involved in volume regulation of human spermatozoa
Mol. Hum. Reprod., December 1, 2005; 11(12): 891 - 897.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
K. T. Kahle, J. Rinehart, P. de los Heros, A. Louvi, P. Meade, N. Vazquez, S. C. Hebert, G. Gamba, I. Gimenez, and R. P. Lifton
WNK3 modulates transport of Cl