PHYSIOLOGICAL REVIEWS   Vol. 78 No. 1 January 1998, pp. 247-306
Copyright ©1998 The American Physiological Society

Functional Significance of Cell Volume Regulatory Mechanisms

FLORIAN LANG, GILLIAN L. BUSCH, MARKUS RITTER, HARALD VÖLKL, SIEGFRIED WALDEGGER, ERICH GULBINS, AND DIETER HÄUSSINGER

Institute of Physiology, University of Tübingen, Tübingen; Department of Internal Medicine, University of Düsseldorf, Düsseldorf, Germany; and Department of Internal Medicine and Institute of Physiology, University of Innsbruck, Innsbruck, Austria

Lang, Florian, Gillian L. Busch, Markus Ritter, Harald Völkl, Siegfried Waldegger, Erich Gulbins, and Dieter Häussinger. Functional Significance of Cell Volume Regulatory Mechanisms. Physiol. Rev. 78: 247-306, 1998.  To survive, cells have to avoid excessive alterations of cell volume that jeopardize structural integrity and constancy of intracellular milieu. The function of cellular proteins seems specifically sensitive to dilution and concentration, determining the extent of macromolecular crowding. Even at constant extracellular osmolarity, volume constancy of any mammalian cell is permanently challenged by transport of osmotically active substances across the cell membrane and formation or disappearance of cellular osmolarity by metabolism. Thus cell volume constancy requires the continued operation of cell volume regulatory mechanisms, including ion transport across the cell membrane as well as accumulation or disposal of organic osmolytes and metabolites. The various cell volume regulatory mechanisms are triggered by a multitude of intracellular signaling events including alterations of cell membrane potential and of intracellular ion composition, various second messenger cascades, phosphorylation of diverse target proteins, and altered gene expression. Hormones and mediators have been shown to exploit the volume regulatory machinery to exert their effects. Thus cell volume may be considered a second message in the transmission of hormonal signals. Accordingly, alterations of cell volume and volume regulatory mechanisms participate in a wide variety of cellular functions including epithelial transport, metabolism, excitation, hormone release, migration, cell proliferation, and cell death.

This article has been cited by other articles:

				Y.-F. Chen, C.-Y. Chou, R. J. Wilkins, J. C. Ellory, D. B. Mount, and M.-R. Shen Motor Protein-Dependent Membrane Trafficking of KCl Cotransporter-4 Is Important for Cancer Cell Invasion Cancer Res., November 15, 2009; 69(22): 8585 - 8593. [Abstract] [Full Text] [PDF]

				J. Almaca, Y. Tian, F. Aldehni, J. Ousingsawat, P. Kongsuphol, J. R. Rock, B. D. Harfe, R. Schreiber, and K. Kunzelmann TMEM16 Proteins Produce Volume-regulated Chloride Currents That Are Reduced in Mice Lacking TMEM16A J. Biol. Chem., October 16, 2009; 284(42): 28571 - 28578. [Abstract] [Full Text] [PDF]

				S. C. Chow, L. Y. Ching, A. M. F. Wong, and C. K. C. Wong Cloning and regulation of expression of the Na+-Cl--taurine transporter in gill cells of freshwater Japanese eels J. Exp. Biol., October 15, 2009; 212(20): 3205 - 3210. [Abstract] [Full Text] [PDF]

				Q. Xiao, K. Yu, Y.-y. Cui, and H. C. Hartzell Dysregulation of human bestrophin-1 by ceramide-induced dephosphorylation J. Physiol., September 15, 2009; 587(18): 4379 - 4391. [Abstract] [Full Text] [PDF]

				I. H. Lambert, T. K. Klausen, A. Bergdahl, C. Hougaard, and E. K. Hoffmann ROS activate KCl cotransport in nonadherent Ehrlich ascites cells but K+ and Cl- channels in adherent Ehrlich Lettre and NIH3T3 cells Am J Physiol Cell Physiol, July 1, 2009; 297(1): C198 - C206. [Abstract] [Full Text] [PDF]

				E. H. Zhou, X. Trepat, C. Y. Park, G. Lenormand, M. N. Oliver, S. M. Mijailovich, C. Hardin, D. A. Weitz, J. P. Butler, and J. J. Fredberg Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition PNAS, June 30, 2009; 106(26): 10632 - 10637. [Abstract] [Full Text] [PDF]

				K. M. Boini, D. Graf, A. M. Hennige, S. Koka, D. S. Kempe, K. Wang, T. F. Ackermann, M. Foller, V. Vallon, K. Pfeifer, et al. Enhanced insulin sensitivity of gene-targeted mice lacking functional KCNQ1 Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2009; 296(6): R1695 - R1701. [Abstract] [Full Text] [PDF]

				D. Duan Phenomics of cardiac chloride channels: the systematic study of chloride channel function in the heart J. Physiol., May 15, 2009; 587(10): 2163 - 2177. [Abstract] [Full Text] [PDF]

				Y. Okada, K. Sato, and T. Numata Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel J. Physiol., May 15, 2009; 587(10): 2141 - 2149. [Abstract] [Full Text] [PDF]

				M. Avella, O. Ducoudret, D. F. Pisani, and P. Poujeol Swelling-activated transport of taurine in cultured gill cells of sea bass: physiological adaptation and pavement cell plasticity Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1149 - R1160. [Abstract] [Full Text] [PDF]

				A. C. P. Thirone, P. Speight, M. Zulys, O. D. Rotstein, K. Szaszi, S. F. Pedersen, and A. Kapus Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response Am J Physiol Cell Physiol, March 1, 2009; 296(3): C463 - C475. [Abstract] [Full Text] [PDF]

				T. Morgenstern, G. Kurp, H. Mahmud, M. Foller, F. Lang, and F. C. Luft Surreptitious hyperkalaemia and its complications NDT Plus, February 1, 2009; 2(1): 23 - 26. [Abstract] [Full Text] [PDF]

				S. Watanabe, T. Hirano, E. G. Grau, and T. Kaneko Osmosensitivity of prolactin cells is enhanced by the water channel aquaporin-3 in a euryhaline Mozambique tilapia (Oreochromis mossambicus) Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R446 - R453. [Abstract] [Full Text] [PDF]

				E. K. Hoffmann, I. H. Lambert, and S. F. Pedersen Physiology of Cell Volume Regulation in Vertebrates Physiol Rev, January 1, 2009; 89(1): 193 - 277. [Abstract] [Full Text] [PDF]

				L.-T. Chien and H. C. Hartzell Rescue of Volume-regulated Anion Current by Bestrophin Mutants with Altered Charge Selectivity J. Gen. Physiol., November 1, 2008; 132(5): 537 - 546. [Abstract] [Full Text] [PDF]

				K. H. Ahmed and B. Pelster Ionic determinants of pH of acidic compartments under hypertonic conditions in trout hepatocytes J. Exp. Biol., October 15, 2008; 211(20): 3306 - 3314. [Abstract] [Full Text] [PDF]

				Z. Zhang and C. W. Bourque Amplification of Transducer Gain by Angiotensin II-Mediated Enhancement of Cortical Actin Density in Osmosensory Neurons J. Neurosci., September 17, 2008; 28(38): 9536 - 9544. [Abstract] [Full Text] [PDF]

				J. Jorgacevski, M. Stenovec, M. Kreft, A. Bajic, B. Rituper, N. Vardjan, S. Stojilkovic, and R. Zorec Hypotonicity and peptide discharge from a single vesicle Am J Physiol Cell Physiol, September 1, 2008; 295(3): C624 - C631. [Abstract] [Full Text] [PDF]

				J. R. Schelling and B. G. Abu Jawdeh Regulation of cell survival by Na+/H+ exchanger-1 Am J Physiol Renal Physiol, September 1, 2008; 295(3): F625 - F632. [Abstract] [Full Text] [PDF]

				D. Heitzmann and R. Warth Physiology and Pathophysiology of Potassium Channels in Gastrointestinal Epithelia Physiol Rev, July 1, 2008; 88(3): 1119 - 1182. [Abstract] [Full Text] [PDF]

				Y. Jing, J. A. Dowdy, M. R. Van Scott, and J. S. Fedan Hyperosmolarity-Induced Dilation and Epithelial Bioelectric Responses of Guinea Pig Trachea in Vitro: Role of Kinase Signaling J. Pharmacol. Exp. Ther., July 1, 2008; 326(1): 186 - 195. [Abstract] [Full Text] [PDF]

				W. K. F. Tse, S. C. Chow, and C. K. C. Wong The cloning of eel osmotic stress transcription factor and the regulation of its expression in primary gill cell culture J. Exp. Biol., June 15, 2008; 211(12): 1964 - 1968. [Abstract] [Full Text] [PDF]

				E. Shumilina, R. S. Lam, F. Wolbing, N. Matzner, I. M. Zemtsova, M. Sobiesiak, H. Mahmud, U. Sausbier, T. Biedermann, P. Ruth, et al. Blunted IgE-Mediated Activation of Mast Cells in Mice Lacking the Ca2+-Activated K+ Channel KCa3.1 J. Immunol., June 15, 2008; 180(12): 8040 - 8047. [Abstract] [Full Text] [PDF]

				V. Kiedaisch, A. Akel, O. M Niemoeller, T. Wieder, and F. Lang Zinc-induced suicidal erythrocyte death Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1530 - 1534. [Abstract] [Full Text] [PDF]

				H. C. Hartzell, Z. Qu, K. Yu, Q. Xiao, and L.-T. Chien Molecular Physiology of Bestrophins: Multifunctional Membrane Proteins Linked to Best Disease and Other Retinopathies Physiol Rev, April 1, 2008; 88(2): 639 - 672. [Abstract] [Full Text] [PDF]

				F. Martinez-Pastor, E. Cabrita, F. Soares, L. Anel, and M. T. Dinis Multivariate cluster analysis to study motility activation of Solea senegalensis spermatozoa: a model for marine teleosts Reproduction, April 1, 2008; 135(4): 449 - 459. [Abstract] [Full Text] [PDF]

				M.-B. Nielsen, S. T. Christensen, and E. K. Hoffmann Effects of osmotic stress on the activity of MAPKs and PDGFR-{beta}-mediated signal transduction in NIH-3T3 fibroblasts Am J Physiol Cell Physiol, April 1, 2008; 294(4): C1046 - C1055. [Abstract] [Full Text] [PDF]

				V. Nechyporuk-Zloy, P. Dieterich, H. Oberleithner, C. Stock, and A. Schwab Dynamics of single potassium channel proteins in the plasma membrane of migrating cells Am J Physiol Cell Physiol, April 1, 2008; 294(4): C1096 - C1102. [Abstract] [Full Text] [PDF]

				L. Lizana, B. Bauer, and O. Orwar Controlling the rates of biochemical reactions and signaling networks by shape and volume changes PNAS, March 18, 2008; 105(11): 4099 - 4104. [Abstract] [Full Text] [PDF]

				P. K. Lauf, S. Misri, A. A. Chimote, and N. C. Adragna Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cells Am J Physiol Cell Physiol, March 1, 2008; 294(3): C820 - C832. [Abstract] [Full Text] [PDF]

				P. Coulon, H.-J. Wusten, P. Hochstrate, and P. W. Dierkes Swelling-activated chloride channels in leech Retzius neurons J. Exp. Biol., February 15, 2008; 211(4): 630 - 641. [Abstract] [Full Text] [PDF]

				A. d. de Tassigny, A. Berdeaux, R. Souktani, P. Henry, and B. Ghaleh The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2 Eur J Heart Fail, January 1, 2008; 10(1): 39 - 46. [Abstract] [Full Text] [PDF]

				D. E. Pafundo, O. Chara, M. P. Faillace, G. Krumschnabel, and P. J. Schwarzbaum Kinetics of ATP release and cell volume regulation of hyposmotically challenged goldfish hepatocytes Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R220 - R233. [Abstract] [Full Text] [PDF]

				C. W. McLaughlin, S. Zellhuber-McMillan, A. D. C. Macknight, and M. M. Civan Electron microprobe analysis of rabbit ciliary epithelium indicates enhanced secretion posteriorly and enhanced absorption anteriorly Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1455 - C1466. [Abstract] [Full Text] [PDF]

				J. B. Kelley and B. M. Paschal Hyperosmotic Stress Signaling to the Nucleus Disrupts the Ran Gradient and the Production of RanGTP Mol. Biol. Cell, November 1, 2007; 18(11): 4365 - 4376. [Abstract] [Full Text] [PDF]

				L.-T. Chien and H. C. Hartzell Drosophila Bestrophin-1 Chloride Current Is Dually Regulated by Calcium and Cell Volume J. Gen. Physiol., October 29, 2007; 130(5): 513 - 524. [Abstract] [Full Text] [PDF]

				M. Sjostrom, K. Stenstrom, K. Eneling, J. Zwiller, A. I. Katz, H. Takemori, and A. M. Bertorello SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process PNAS, October 23, 2007; 104(43): 16922 - 16927. [Abstract] [Full Text] [PDF]

				F. Lang, V. Vallon, M. Knipper, and P. Wangemann Functional significance of channels and transporters expressed in the inner ear and kidney Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1187 - C1208. [Abstract] [Full Text] [PDF]

				F. Lang Mechanisms and Significance of Cell Volume Regulation J. Am. Coll. Nutr., October 1, 2007; 26(suppl_5): 613S - 623S. [Abstract] [Full Text] [PDF]

				N. Rockel, C. Esser, S. Grether-Beck, U. Warskulat, U. Flogel, A. Schwarz, T. Schwarz, D. Yarosh, D. Haussinger, and J. Krutmann The Osmolyte Taurine Protects against Ultraviolet B Radiation-Induced Immunosuppression J. Immunol., September 15, 2007; 179(6): 3604 - 3612. [Abstract] [Full Text] [PDF]

				B. L. vanTol, S. Missan, J. Crack, S. Moser, W. H. Baldridge, P. Linsdell, and E. A. Cowley Contribution of KCNQ1 to the regulatory volume decrease in the human mammary epithelial cell line MCF-7 Am J Physiol Cell Physiol, September 1, 2007; 293(3): C1010 - C1019. [Abstract] [Full Text] [PDF]

				M. Boschmann, J. Steiniger, G. Franke, A. L. Birkenfeld, F. C. Luft, and J. Jordan Water Drinking Induces Thermogenesis through Osmosensitive Mechanisms J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3334 - 3337. [Abstract] [Full Text] [PDF]

				M. Boschmann and F. Thielecke The Effects of Epigallocatechin-3-Gallate on Thermogenesis and Fat Oxidation in Obese Men: A Pilot Study J. Am. Coll. Nutr., August 1, 2007; 26(4): 389S - 395S. [Abstract] [Full Text] [PDF]

				B. F. Bessac and A. Fleig TRPM7 channel is sensitive to osmotic gradients in human kidney cells J. Physiol., August 1, 2007; 582(3): 1073 - 1086. [Abstract] [Full Text] [PDF]

				D. K. Nielsen, A. K. Jensen, H. Harbak, S. C. Christensen, and L. O. Simonsen Cell content of phosphatidylinositol (4,5)bisphosphate in Ehrlich mouse ascites tumour cells in response to cell volume perturbations in anisotonic and in isosmotic media J. Physiol., August 1, 2007; 582(3): 1027 - 1036. [Abstract] [Full Text] [PDF]

				A M Petrunkina, D Waberski, A R Gunzel-Apel, and E Topfer-Petersen Determinants of sperm quality and fertility in domestic species Reproduction, July 1, 2007; 134(1): 3 - 17. [Abstract] [Full Text] [PDF]

				W. K. F. Tse, D. W. T. Au, and C. K. C. Wong Effect of osmotic shrinkage and hormones on the expression of Na+/H+ exchanger-1, Na+/K+/2Cl- cotransporter and Na+/K+-ATPase in gill pavement cells of freshwater adapted Japanese eel, Anguilla japonica J. Exp. Biol., June 15, 2007; 210(12): 2113 - 2120. [Abstract] [Full Text] [PDF]

				K. Strange Revisiting the Krogh Principle in the post-genome era: Caenorhabditis elegans as a model system for integrative physiology research J. Exp. Biol., May 1, 2007; 210(9): 1622 - 1631. [Abstract] [Full Text] [PDF]

				A. Antolic, R. Harrison, C. Farlinger, N. M. Cermak, S. J. Peters, P. LeBlanc, and B. D. Roy Effect of extracellular osmolality on cell volume and resting metabolism in mammalian skeletal muscle Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1994 - R2000. [Abstract] [Full Text] [PDF]

				F. Kamachi, H. S. Ban, N. Hirasawa, and K. Ohuchi Inhibition of Lipopolysaccharide-Induced Prostaglandin E2 Production and Inflammation by the Na+/H+ Exchanger Inhibitors J. Pharmacol. Exp. Ther., April 1, 2007; 321(1): 345 - 352. [Abstract] [Full Text] [PDF]

				G. Tamma, G. Procino, M. Svelto, and G. Valenti Hypotonicity causes actin reorganization and recruitment of the actin-binding ERM protein moesin in membrane protrusions in collecting duct principal cells Am J Physiol Cell Physiol, April 1, 2007; 292(4): C1476 - C1484. [Abstract] [Full Text] [PDF]

				C. Schafer, L. Hoffmann, K. Heldt, M. R. Lornejad-Schafer, G. Brauers, T. Gehrmann, T. A. Garrow, D. Haussinger, E. Mayatepek, B. C. Schwahn, et al. Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells Am J Physiol Gastrointest Liver Physiol, April 1, 2007; 292(4): G1089 - G1098. [Abstract] [Full Text] [PDF]

				O. Bachmann, A. Heinzmann, A. Mack, M. P. Manns, and U. Seidler Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G711 - G717. [Abstract] [Full Text] [PDF]

				A M Petrunkina, R A P Harrison, M Tsolova, E Jebe, and E Topfer-Petersen Signalling pathways involved in the control of sperm cell volume Reproduction, January 1, 2007; 133(1): 61 - 73. [Abstract] [Full Text] [PDF]

				T. Numata, T. Shimizu, and Y. Okada TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells Am J Physiol Cell Physiol, January 1, 2007; 292(1): C460 - C467. [Abstract] [Full Text] [PDF]

				M. Takii, T. Ishikawa, H. Tsuda, K. Kanatani, T. Sunouchi, Y. Kaneko, and K. Nakayama Involvement of stretch-activated cation channels in hypotonically induced insulin secretion in rat pancreatic beta-cells Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1405 - C1411. [Abstract] [Full Text] [PDF]

				S. F. Pedersen, K. A. Poulsen, and I. H. Lambert Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1286 - C1296. [Abstract] [Full Text] [PDF]

				T. Klein, T.G. Cooper, and C.H. Yeung The Role of Potassium Chloride Cotransporters in Murine and Human Sperm Volume Regulation Biol Reprod, December 1, 2006; 75(6): 853 - 858. [Abstract] [Full Text] [PDF]

				R. Rexhepaj, F. Grahammer, H. Volkl, C. Remy, C. A. Wagner, D. Sandulache, F. Artunc, G. Henke, S. Nammi, G. Capasso, et al. Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice FASEB J, November 1, 2006; 20(13): 2214 - 2222. [Abstract] [Full Text] [PDF]

				A. M. Heacock, D. J. Foster, and S. K. Fisher Prostanoid Receptors Regulate the Volume-Sensitive Efflux of Osmolytes from Murine Fibroblasts via a Cyclic AMP-Dependent Mechanism J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 963 - 971. [Abstract] [Full Text] [PDF]

				C. M. McNicholas-Bevensee, K. B. DeAndrade, W. E. Bradley, L. J. Dell'Italia, P. A. Lucchesi, and M. O. Bevensee Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure Cardiovasc Res, November 1, 2006; 72(2): 262 - 270. [Abstract] [Full Text] [PDF]

				F. Lang, C. Bohmer, M. Palmada, G. Seebohm, N. Strutz-Seebohm, and V. Vallon (Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms. Physiol Rev, October 1, 2006; 86(4): 1151 - 1178. [Abstract] [Full Text] [PDF]

				R. Reinehr, S. Becker, J. Braun, A. Eberle, S. Grether-Beck, and D. Haussinger Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis J. Biol. Chem., August 11, 2006; 281(32): 23150 - 23166. [Abstract] [Full Text] [PDF]

				S. A. Kempson, J. M. Edwards, and M. Sturek Inhibition of the renal betaine transporter by calcium ions Am J Physiol Renal Physiol, August 1, 2006; 291(2): F305 - F313. [Abstract] [Full Text] [PDF]

				A. P. Minton How can biochemical reactions within cells differ from those in test tubes? J. Cell Sci., July 15, 2006; 119(14): 2863 - 2869. [Abstract] [Full Text] [PDF]

				E. C. Aromataris, M. L. Roberts, G. J. Barritt, and G. Y. Rychkov Glucagon activates Ca2+ and Cl- channels in rat hepatocytes J. Physiol., June 15, 2006; 573(3): 611 - 625. [Abstract] [Full Text] [PDF]

				J. A. Usher-Smith, J. A. Fraser, P. S. J. Bailey, J. L. Griffin, and C. L.-H. Huang The influence of intracellular lactate and H+ on cell volume in amphibian skeletal muscle J. Physiol., June 15, 2006; 573(3): 799 - 818. [Abstract] [Full Text] [PDF]

				K Terashima, A Takeuchi, N Sarai, S Matsuoka, E.B Shim, C.H Leem, and A Noma Modelling Cl- homeostasis and volume regulation of the cardiac cell Phil Trans R Soc A, May 15, 2006; 364(1842): 1245 - 1265. [Abstract] [Full Text] [PDF]

				A. M. Heacock, M. S. Dodd, and S. K. Fisher Regulation of Volume-Sensitive Osmolyte Efflux from Human SH-SY5Y Neuroblastoma Cells following Activation of Lysophospholipid Receptors J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 685 - 693. [Abstract] [Full Text] [PDF]

				I. F. Abdullaev, A. Rudkouskaya, G. P. Schools, H. K. Kimelberg, and A. A. Mongin Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes J. Physiol., May 1, 2006; 572(3): 677 - 689. [Abstract] [Full Text] [PDF]

				U. Lodemann and H. Martens Effects of diet and osmotic pressure on Na+ transport and tissue conductance of sheep isolated rumen epithelium Exp Physiol, May 1, 2006; 91(3): 539 - 550. [Abstract] [Full Text] [PDF]

				N.-A. Liu, Q. Liu, K. Wawrowsky, Z. Yang, S. Lin, and S. Melmed Prolactin Receptor Signaling Mediates the Osmotic Response of Embryonic Zebrafish Lactotrophs Mol. Endocrinol., April 1, 2006; 20(4): 871 - 880. [Abstract] [Full Text] [PDF]

				A. Kurtz and F. Schweda Osmolarity-induced renin secretion from kidneys: evidence for readily releasable renin pools Am J Physiol Renal Physiol, April 1, 2006; 290(4): F797 - F805. [Abstract] [Full Text] [PDF]

				S. Sanchez-Armass, S. R. Sennoune, D. Maiti, F. Ortega, and R. Martinez-Zaguilan Spectral imaging microscopy demonstrates cytoplasmic pH oscillations in glial cells Am J Physiol Cell Physiol, February 1, 2006; 290(2): C524 - C538. [Abstract] [Full Text] [PDF]

				S. Ben-Tabou De-Leon, G. Ben-Zeev, and I. Nussinovitch Effects of osmotic shrinkage on voltage-gated Ca2+ channel currents in rat anterior pituitary cells Am J Physiol Cell Physiol, January 1, 2006; 290(1): C222 - C232. [Abstract] [Full Text] [PDF]

				V. Lyall, H. Pasley, T.-H. T. Phan, S. Mummalaneni, G. L. Heck, A. K. Vinnikova, and J. A. DeSimone Intracellular pH Modulates Taste Receptor Cell Volume and the Phasic Part of the Chorda Tympani Response to Acids J. Gen. Physiol., December 27, 2005; 127(1): 15 - 34. [Abstract] [Full Text] [PDF]

				J.P. Barfield, C.H. Yeung, and T.G. Cooper Characterization of potassium channels involved in volume regulation of human spermatozoa Mol. Hum. Reprod., December 1, 2005; 11(12): 891 - 897. [Abstract] [Full Text] [PDF]

				K. T. Kahle, J. Rinehart, P. de los Heros, A. Louvi, P. Meade, N. Vazquez, S. C. Hebert, G. Gamba, I. Gimenez, and R. P. Lifton WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability PNAS, November 15, 2005; 102(46): 16783 - 16788. [Abstract] [Full Text] [PDF]

				T. A. Cheema, C. E. Ward, and S. K. Fisher Subnanomolar Concentrations of Thrombin Enhance the Volume-Sensitive Efflux of Taurine from Human 1321N1 Astrocytoma Cells J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 755 - 763. [Abstract] [Full Text] [PDF]

				C.H. Yeung, J.P. Barfield, and T.G. Cooper Chloride Channels in Physiological Volume Regulation of Human Spermatozoa Biol Reprod, November 1, 2005; 73(5): 1057 - 1063. [Abstract] [Full Text] [PDF]

				G.-L. Wang, G.-X. Wang, S. Yamamoto, L. Ye, H. Baxter, J. R Hume, and D. Duan Molecular mechanisms of regulation of fast-inactivating voltage-dependent transient outward K+ current in mouse heart by cell volume changes J. Physiol., October 15, 2005; 568(2): 423 - 443. [Abstract] [Full Text] [PDF]

				M. B. Friis, C. R. Friborg, L. Schneider, M.-B. Nielsen, I. H. Lambert, S. T. Christensen, and E. K. Hoffmann Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts J. Physiol., September 1, 2005; 567(2): 427 - 443. [Abstract] [Full Text] [PDF]

				H. L. Ebner, A. Cordas, D. E. Pafundo, P. J. Schwarzbaum, B. Pelster, and G. Krumschnabel Importance of cytoskeletal elements in volume regulatory responses of trout hepatocytes Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R877 - R890. [Abstract] [Full Text] [PDF]

				E. T. Barfod, A. L. Moore, R. F. Melnick, and S. D. Lidofsky Src Regulates Distinct Pathways for Cell Volume Control through Vav and Phospholipase C{gamma} J. Biol. Chem., July 8, 2005; 280(27): 25548 - 25557. [Abstract] [Full Text] [PDF]

				S. Chifflet, J. A. Hernandez, and S. Grasso A possible role for membrane depolarization in epithelial wound healing Am J Physiol Cell Physiol, June 1, 2005; 288(6): C1420 - C1430. [Abstract] [Full Text] [PDF]

				X.-M. Chen, S. P. O'Hara, B. Q. Huang, P. L. Splinter, J. B. Nelson, and N. F. LaRusso Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion PNAS, May 3, 2005; 102(18): 6338 - 6343. [Abstract] [Full Text] [PDF]

				V. P. Wright, P. F. Klawitter, D. F. Iscru, A. J. Merola, and T. L. Clanton Superoxide scavengers augment contractile but not energetic responses to hypoxia in rat diaphragm J Appl Physiol, May 1, 2005; 98(5): 1753 - 1760. [Abstract] [Full Text] [PDF]

				J.P. Barfield, C.H. Yeung, and T.G. Cooper The Effects of Putative K+ Channel Blockers on Volume Regulation of Murine Spermatozoa Biol Reprod, May 1, 2005; 72(5): 1275 - 1281. [Abstract] [Full Text] [PDF]

				S. Jiang and B. Storrie Cisternal Rab Proteins Regulate Golgi Apparatus Redistribution in Response to Hypotonic Stress Mol. Biol. Cell, May 1, 2005; 16(5): 2586 - 2596. [Abstract] [Full Text] [PDF]

				B. Friedrich, D. Alexander, W. K. Aicher, M. Duszenko, T. P. Schaub, J. Passlick-Deetjen, S. Waldegger, S. Wolf, T. Risler, and F. Lang Influence of standard haemodialysis treatment on transcription of human serum- and glucocorticoid-inducible kinase SGK1 and taurine transporter TAUT in blood leukocytes Nephrol. Dial. Transplant., April 1, 2005; 20(4): 768 - 774. [Abstract] [Full Text] [PDF]

				G. Gamba Molecular Physiology and Pathophysiology of Electroneutral Cation-Chloride Cotransporters Physiol Rev, April 1, 2005; 85(2): 423 - 493. [Abstract] [Full Text] [PDF]

				J. A Fraser, C. E. J Rang, J. A Usher-Smith, and C. L.-H Huang Slow volume transients in amphibian skeletal muscle fibres studied in hypotonic solutions J. Physiol., April 1, 2005; 564(1): 51 - 63. [Abstract] [Full Text] [PDF]

				C. Ferreira, F. van Voorst, A. Martins, L. Neves, R. Oliveira, M. C. Kielland-Brandt, C. Lucas, and A. Brandt A Member of the Sugar Transporter Family, Stl1p Is the Glycerol/H+ Symporter in Saccharomyces cerevisiae Mol. Biol. Cell, April 1, 2005; 16(4): 2068 - 2076. [Abstract] [Full Text] [PDF]

				J. A Fraser, C. E Middlebrook, J. A Usher-Smith, C. J Schwiening, and C. L.-H Huang The effect of intracellular acidification on the relationship between cell volume and membrane potential in amphibian skeletal muscle J. Physiol., March 15, 2005; 563(3): 745 - 764. [Abstract] [Full Text] [PDF]

				M. I Lindinger Intracellular [H+]: a determinant of cell volume in skeletal muscle J. Physiol., March 15, 2005; 563(3): 643 - 643. [Full Text] [PDF]

				M. Iwamoto, K. Sugino, R. D. Allen, and Y. Naitoh Cell volume control in Paramecium: factors that activate the control mechanisms J. Exp. Biol., February 1, 2005; 208(3): 523 - 537. [Abstract] [Full Text] [PDF]

				D. S. Kempe, P. A. Lang, K. Eisele, B. A. Klarl, T. Wieder, S. M. Huber, C. Duranton, and F. Lang Stimulation of erythrocyte phosphatidylserine exposure by lead ions Am J Physiol Cell Physiol, February 1, 2005; 288(2): C396 - C402. [Abstract] [Full Text] [PDF]

				M. Yamaguchi, Y. Tomiyama, T. Katayama, H. Kitahata, and S. Oshita Involvement of Adenosine Triphosphate-Sensitive Potassium Channels in the Response of Membrane Potential to Hyperosmolality in Cultured Human Aorta Endothelial Cells Anesth. Analg., February 1, 2005; 100(2): 419 - 426. [Abstract] [Full Text] [PDF]

				S. T. Lamitina and K. Strange Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress Am J Physiol Cell Physiol, February 1, 2005; 288(2): C467 - C474. [Abstract] [Full Text] [PDF]