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Physiol. Rev. 77: 901-930, 1997;
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Physiological Reviews, Vol 77, 901-930, Copyright © 1997 by American Physiological Society

JOURNAL ARTICLE

Store depletion and calcium influx

A. B. Parekh and R. Penner
Department of Membrane Biophysics, Max-Planck-Institute for Biophysical Chemistry, Gottingen, Germany.

Calcium influx in nonexcitable cells regulates such diverse processes as exocytosis, contraction, enzyme control, gene regulation, cell proliferation, and apoptosis. The dominant Ca2+ entry pathway in these cells is the store-operated one, in which Ca2+ entry is governed by the Ca2+ content of the agonist-sensitive intracellular Ca2+ stores. Only recently has a Ca2+ current been described that is activated by store depletion. The properties of this new current, called Ca2+ release-activated Ca2+ current (ICRAC), have been investigated in detail using the patch-clamp technique. Despite intense research, the nature of the signal that couples Ca2+ store content to the Ca2+ channels in the plasma membrane has remained elusive. Although ICRAC appears to be the most effective and widespread influx pathway, other store-operated currents have also been observed. Although the Ca2+ release-activated Ca2+ channel has not yet been cloned, evidence continues to accumulate that the Drosophila trp gene might encode a store-operated Ca2+ channel. In this review, we describe the historical development of the field of Ca2+ signaling and the discovery of store-operated Ca2+ currents. We focus on the electrophysiological properties of the prototype store-operated current ICRAC, discuss the regulatory mechanisms that control it, and finally consider recent advances toward the identification of molecular mechanisms involved in this ubiquitous and important Ca2+ entry pathway.


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M. A. Spassova, J. Soboloff, L.-P. He, W. Xu, M. A. Dziadek, and D. L. Gill
STIM1 has a plasma membrane role in the activation of store-operated Ca2+ channels.
PNAS, March 14, 2006; 103(11): 4040 - 4045.
[Abstract] [Full Text] [PDF]

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 J BiochemHome page
T. Ebihara, F. Guo, L. Zhang, J. Y. Kim, and D. Saffen
Muscarinic Acetylcholine Receptors Stimulate Ca2+ Influx in PC12D Cells Predominantly via Activation of Ca2+ Store-Operated Channels.
J. Biochem., March 1, 2006; 139(3): 449 - 458.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
L. Nunez, R. A. Valero, L. Senovilla, S. Sanz-Blasco, J. Garcia-Sancho, and C. Villalobos
Cell proliferation depends on mitochondrial Ca2+ uptake: inhibition by salicylate
J. Physiol., February 15, 2006; 571(1): 57 - 73.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
J. R. H. Mauban, K. Wilkinson, C. Schach, and J. X.-J. Yuan
Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells
Am J Physiol Cell Physiol, February 1, 2006; 290(2): C325 - C336.
[Abstract] [Full Text] [PDF]

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 Sci SignalHome page
C. Hisatsune and K. Mikoshiba
Novel Compartment Implicated in Calcium Signaling--Is It an "Induced Coupling Domain"?
Sci. Signal., December 6, 2005; 2005(313): pe53 - pe53.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
D. L. Cioffi, S. Wu, M. Alexeyev, S. R. Goodman, M. X. Zhu, and T. Stevens
Activation of the Endothelial Store-Operated ISOC Ca2+ Channel Requires Interaction of Protein 4.1 With TRPC4
Circ. Res., November 25, 2005; 97(11): 1164 - 1172.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
A. M. Hurne, J. J. O'Brien, D. Wingrove, G. Cherednichenko, P. D. Allen, K. G. Beam, and I. N. Pessah
Ryanodine Receptor Type 1 (RyR1) Mutations C4958S and C4961S Reveal Excitation-coupled Calcium Entry (ECCE) Is Independent of Sarcoplasmic Reticulum Store Depletion
J. Biol. Chem., November 4, 2005; 280(44): 36994 - 37004.
[Abstract] [Full Text] [PDF]

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 J. Pharmacol. Exp. Ther.Home page
C. Feisst, L. Franke, G. Appendino, and O. Werz
Identification of Molecular Targets of the Oligomeric Nonprenylated Acylphloroglucinols from Myrtus communis and Their Implication as Anti-Inflammatory Compounds
J. Pharmacol. Exp. Ther., October 1, 2005; 315(1): 389 - 396.
[Abstract] [Full Text] [PDF]

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 JCBHome page
M. Madesh, B. J. Hawkins, T. Milovanova, C. D. Bhanumathy, S. K. Joseph, S. P. RamachandraRao, K. Sharma, T. Kurosaki, and A. B. Fisher
Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis
J. Cell Biol., September 26, 2005; 170(7): 1079 - 1090.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
O. Mignen, J. L Thompson, and T. J Shuttleworth
Arachidonate-regulated Ca2+-selective (ARC) channel activity is modulated by phosphorylation and involves an A-kinase anchoring protein
J. Physiol., September 15, 2005; 567(3): 787 - 798.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Y. Kim and D. Saffen
Activation of M1 Muscarinic Acetylcholine Receptors Stimulates the Formation of a Multiprotein Complex Centered on TRPC6 Channels
J. Biol. Chem., September 9, 2005; 280(36): 32035 - 32047.
[Abstract] [Full Text] [PDF]

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 JEMHome page
S. Feske, M. Prakriya, A. Rao, and R. S. Lewis
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients
J. Exp. Med., September 6, 2005; 202(5): 651 - 662.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
E. Bradley, M. A. Hollywood, N. G. McHale, K. D. Thornbury, and G. P. Sergeant
Pacemaker activity in urethral interstitial cells is not dependent on capacitative calcium entry
Am J Physiol Cell Physiol, September 1, 2005; 289(3): C625 - C632.
[Abstract] [Full Text] [PDF]

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 J. Pharmacol. Exp. Ther.Home page
S. Kazerounian, G. M. Pitari, F. J. Shah, G. S. Frick, M. Madesh, I. Ruiz-Stewart, S. Schulz, G. Hajnoczky, and S. A. Waldman
Proliferative Signaling by Store-Operated Calcium Channels Opposes Colon Cancer Cell Cytostasis Induced by Bacterial Enterotoxins
J. Pharmacol. Exp. Ther., September 1, 2005; 314(3): 1013 - 1022.
[Abstract] [Full Text] [PDF]

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 BloodHome page
G. Tolhurst, C. Vial, C. Leon, C. Gachet, R. J. Evans, and M. P. Mahaut-Smith
Interplay between P2Y1, P2Y12, and P2X1 receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling
Blood, September 1, 2005; 106(5): 1644 - 1651.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
A. Sampieri, M. Diaz-Munoz, A. Antaramian, and L. Vaca
The Foot Structure from the Type 1 Ryanodine Receptor Is Required for Functional Coupling to Store-operated Channels
J. Biol. Chem., July 1, 2005; 280(26): 24804 - 24815.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. Weigand, J. Foxson, J. Wang, L. A. Shimoda, and J. T. Sylvester
Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca2+ and nonselective cation channels
Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L5 - L13.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
M Liu, A. P Albert, and W. A Large
Facilitatory effect of Ins(1,4,5)P3 on store-operated Ca2+-permeable cation channels in rabbit portal vein myocytes
J. Physiol., July 1, 2005; 566(1): 161 - 171.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
X. Liu, B. C. Bandyopadhyay, B. B. Singh, K. Groschner, and I. S. Ambudkar
Molecular Analysis of a Store-operated and 2-Acetyl-sn-glycerol-sensitive Non-selective Cation Channel: HETEROMERIC ASSEMBLY OF TRPC1-TRPC3
J. Biol. Chem., June 3, 2005; 280(22): 21600 - 21606.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
W. Cao, K. M. Harnett, L. Cheng, M. T. Kirber, J. Behar, and P. Biancani
H2O2: a mediator of esophagitis-induced damage to calcium-release mechanisms in cat lower esophageal sphincter
Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1170 - G1178.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Wang, L. A. Shimoda, L. Weigand, W. Wang, D. Sun, and J. T. Sylvester
Acute hypoxia increases intracellular [Ca2+] in pulmonary arterial smooth muscle by enhancing capacitative Ca2+ entry
Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1059 - L1069.
[Abstract] [Full Text] [PDF]

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 Eur Respir JHome page
R. Goggel and S. Uhlig
The inositol trisphosphate pathway mediates platelet-activating-factor-induced pulmonary oedema
Eur. Respir. J., May 1, 2005; 25(5): 849 - 857.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
V. Bugaj, V. Alexeenko, A. Zubov, L. Glushankova, A. Nikolaev, Z. Wang, E. Kaznacheyeva, I. Bezprozvanny, and G. N. Mozhayeva
Functional Properties of Endogenous Receptor- and Store-operated Calcium Influx Channels in HEK293 Cells
J. Biol. Chem., April 29, 2005; 280(17): 16790 - 16797.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
T. Oka, M. Hori, and H. Ozaki
Microtubule Disruption Suppresses Allergic Response through the Inhibition of Calcium Influx in the Mast Cell Degranulation Pathway
J. Immunol., April 15, 2005; 174(8): 4584 - 4589.
[Abstract] [Full Text] [PDF]

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 Physiol. Rev.Home page
A. B. Parekh and J. W. Putney Jr.
Store-Operated Calcium Channels
Physiol Rev, April 1, 2005; 85(2): 757 - 810.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L.-P. He, T. Hewavitharana, J. Soboloff, M. A. Spassova, and D. L. Gill
A Functional Link between Store-operated and TRPC Channels Revealed by the 3,5-Bis(trifluoromethyl)pyrazole Derivative, BTP2
J. Biol. Chem., March 25, 2005; 280(12): 10997 - 11006.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. Iwai, Y. Tateishi, M. Hattori, A. Mizutani, T. Nakamura, A. Futatsugi, T. Inoue, T. Furuichi, T. Michikawa, and K. Mikoshiba
Molecular Cloning of Mouse Type 2 and Type 3 Inositol 1,4,5-Trisphosphate Receptors and Identification of a Novel Type 2 Receptor Splice Variant
J. Biol. Chem., March 18, 2005; 280(11): 10305 - 10317.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
B. Moreau, S. Straube, R. J. Fisher, J. W. Putney Jr., and A. B. Parekh
Ca2+-Calmodulin-dependent Facilitation and Ca2+ Inactivation of Ca2+ Release-activated Ca2+ Channels
J. Biol. Chem., March 11, 2005; 280(10): 8776 - 8783.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. Dong, Z. M. Sellers, A. Smith, J. Y. C. Chow, and K. E. Barrett
Na+/Ca2+ exchange regulates Ca2+-dependent duodenal mucosal ion transport and HCO3- secretion in mice
Am J Physiol Gastrointest Liver Physiol, March 1, 2005; 288(3): G457 - G465.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
L. C. Ng, S. M Wilson, and J. R Hume
Mobilization of sarcoplasmic reticulum stores by hypoxia leads to consequent activation of capacitative Ca2+ entry in isolated canine pulmonary arterial smooth muscle cells
J. Physiol., March 1, 2005; 563(2): 409 - 419.
[Abstract] [Full Text] [PDF]

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 Sci SignalHome page
C. Montell
The TRP Superfamily of Cation Channels
Sci. Signal., February 22, 2005; 2005(272): re3 - re3.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. Zablocki, J. Szczepanowska, and J. Duszynski
Extracellular pH Modifies Mitochondrial Control of Capacitative Calcium Entry in Jurkat Cells
J. Biol. Chem., February 4, 2005; 280(5): 3516 - 3521.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
A. De Luca, B. Nico, A. Liantonio, M. P. Didonna, B. Fraysse, S. Pierno, R. Burdi, D. Mangieri, J.-F. Rolland, C. Camerino, et al.
A Multidisciplinary Evaluation of the Effectiveness of Cyclosporine A in Dystrophic Mdx Mice
Am. J. Pathol., February 1, 2005; 166(2): 477 - 489.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
S. Zhang, J. X.-J. Yuan, K. E. Barrett, and H. Dong
Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells
Am J Physiol Cell Physiol, February 1, 2005; 288(2): C245 - C252.
[Abstract] [Full Text] [PDF]

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 J. Appl. Physiol.Home page
J. R. H. Mauban, C. V. Remillard, and J. X.-J. Yuan
Hypoxic pulmonary vasoconstriction: role of ion channels
J Appl Physiol, January 1, 2005; 98(1): 415 - 420.
[Abstract] [Full Text] [PDF]


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