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Physiol. Rev. 77: 1033-1079, 1997; Free Article
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Physiological Reviews, Vol 77, 1033-1079, Copyright © 1997 by American Physiological Society

JOURNAL ARTICLE

Mast cells

D. D. Metcalfe, D. Baram and Y. A. Mekori
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Mast cells are found resident in tissues throughout the body, particularly in association with structures such as blood vessels and nerves, and in proximity to surfaces that interface the external environment. Mast cells are bone marrow-derived and particularly depend upon stem cell factor for their survival. Mast cells express a variety of phenotypic features within tissues as determined by the local environment. Withdrawal of required growth factors results in mast cell apoptosis. Mast cells appear to be highly engineered cells with multiple critical biological functions. They may be activated by a number of stimuli that are both Fc epsilon RI dependent and Fc epsilon RI independent. Activation through various receptors leads to distinct signaling pathways. After activation, mast cells may immediately extrude granule-associated mediators and generate lipid-derived substances that induce immediate allergic inflammation. Mast cell activation may also be followed by the synthesis of chemokines and cytokines. Cytokine and chemokine secretion, which occurs hours later, may contribute to chronic inflammation. Biological functions of mast cells appear to include a role in innate immunity, involvement in host defense mechanisms against parasitic infestations, immunomodulation of the immune system, and tissue repair and angiogenesis.


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J. S. Janicki, G. L. Brower, J. D. Gardner, M. F. Forman, J. A. Stewart Jr., D. B. Murray, and A. L. Chancey
Cardiac mast cell regulation of matrix metalloproteinase-related ventricular remodeling in chronic pressure or volume overload
Cardiovasc Res, February 15, 2006; 69(3): 657 - 665.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
T. Oki, J. Kitaura, K. Eto, Y. Lu, M. Maeda-Yamamoto, N. Inagaki, H. Nagai, Y. Yamanishi, H. Nakajina, H. Kumagai, et al.
Integrin {alpha}IIb{beta}3 Induces the Adhesion and Activation of Mast Cells through Interaction with Fibrinogen
J. Immunol., January 1, 2006; 176(1): 52 - 60.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
E. Zudaire, A. Martinez, M. Garayoa, R. Pio, G. Kaur, M. R. Woolhiser, D. D. Metcalfe, W. A. Hook, R. P. Siraganian, T. A. Guise, et al.
Adrenomedullin Is a Cross-Talk Molecule that Regulates Tumor and Mast Cell Function during Human Carcinogenesis
Am. J. Pathol., January 1, 2006; 168(1): 280 - 291.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
J. R. Timoshanko, R. Kitching, T. J. Semple, P. G. Tipping, and S. R. Holdsworth
A Pathogenetic Role for Mast Cells in Experimental Crescentic Glomerulonephritis
J. Am. Soc. Nephrol., January 1, 2006; 17(1): 150 - 159.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
Y. Liu, K. Furuta, R. Teshima, N. Shirata, Y. Sugimoto, A. Ichikawa, and S. Tanaka
Critical Role of Protein Kinase C {beta}II in Activation of Mast Cells by Monomeric IgE
J. Biol. Chem., November 25, 2005; 280(47): 38976 - 38981.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. Nguyen, A. J. Pace, and B. H. Koller
Age-Induced Reprogramming of Mast Cell Degranulation
J. Immunol., November 1, 2005; 175(9): 5701 - 5707.
[Abstract] [Full Text] [PDF]

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 J. Leukoc. Biol.Home page
J. Noguchi, E. Kuroda, and U. Yamashita
Strain difference of murine bone marrow-derived mast cell functions
J. Leukoc. Biol., September 1, 2005; 78(3): 605 - 611.
[Abstract] [Full Text] [PDF]

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 BloodHome page
C. Moller, J. Alfredsson, M. Engstrom, H. Wootz, Z. Xiang, J. Lennartsson, J.-I. Jonsson, and G. Nilsson
Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim
Blood, August 15, 2005; 106(4): 1330 - 1336.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
C.-C. Chen, M. A. Grimbaldeston, M. Tsai, I. L. Weissman, and S. J. Galli
From The Cover: Identification of mast cell progenitors in adult mice
PNAS, August 9, 2005; 102(32): 11408 - 11413.
[Abstract] [Full Text] [PDF]

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 Arterioscler. Thromb. Vasc. Bio.Home page
K. Al-Nedawi, J. Szemraj, and C. S. Cierniewski
Mast Cell-Derived Exosomes Activate Endothelial Cells to Secrete Plasminogen Activator Inhibitor Type 1
Arterioscler Thromb Vasc Biol, August 1, 2005; 25(8): 1744 - 1749.
[Abstract] [Full Text] [PDF]

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 GutHome page
T Gebhardt, A Lorentz, F Detmer, C Trautwein, H Bektas, M P Manns, and S C Bischoff
Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor {beta}1
Gut, July 1, 2005; 54(7): 928 - 934.
[Abstract] [Full Text] [PDF]

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 J. Pharmacol. Exp. Ther.Home page
C. Bandeira-Melo, A. G. C. Bonavita, B. L. Diaz, P. M. R. e Silva, V. F. Carvalho, P. J. Jose, R. J. Flower, M. Perretti, and M. A. Martins
A Novel Effect for Annexin 1-Derived Peptide Ac2-26: Reduction of Allergic Inflammation in the Rat
J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1416 - 1422.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
A. Lorentz, M. Wilke, G. Sellge, H. Worthmann, J. Klempnauer, M. P. Manns, and S. C. Bischoff
IL-4-Induced Priming of Human Intestinal Mast Cells for Enhanced Survival and Th2 Cytokine Generation Is Reversible and Associated with Increased Activity of ERK1/2 and c-Fos
J. Immunol., June 1, 2005; 174(11): 6751 - 6756.
[Abstract] [Full Text] [PDF]

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 BloodHome page
M. C. Jamur, A. C. G. Grodzki, E. H. Berenstein, M. M. Hamawy, R. P. Siraganian, and C. Oliver
Identification and characterization of undifferentiated mast cells in mouse bone marrow
Blood, June 1, 2005; 105(11): 4282 - 4289.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
F. Henningsson, K. Yamamoto, P. Saftig, T. Reinheckel, C. Peters, S. D. Knight, and G. Pejler
A role for cathepsin E in the processing of mast-cell carboxypeptidase A
J. Cell Sci., May 1, 2005; 118(9): 2035 - 2042.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
T. Oka, M. Hori, and H. Ozaki
Microtubule Disruption Suppresses Allergic Response through the Inhibition of Calcium Influx in the Mast Cell Degranulation Pathway
J. Immunol., April 15, 2005; 174(8): 4584 - 4589.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
N. Miyahara, K. Takeda, S. Miyahara, C. Taube, A. Joetham, T. Koya, S. Matsubara, A. Dakhama, A. M. Tager, A. D. Luster, et al.
Leukotriene B4 Receptor-1 Is Essential for Allergen-Mediated Recruitment of CD8+ T Cells and Airway Hyperresponsiveness
J. Immunol., April 15, 2005; 174(8): 4979 - 4984.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
Y. Kanamaru, K. Sumiyoshi, H. Ushio, H. Ogawa, K. Okumura, and A. Nakao
Smad3 Deficiency in Mast Cells Provides Efficient Host Protection against Acute Septic Peritonitis
J. Immunol., April 1, 2005; 174(7): 4193 - 4197.
[Abstract] [Full Text] [PDF]

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 JEMHome page
J. Sasaki, T. Sasaki, M. Yamazaki, K. Matsuoka, C. Taya, H. Shitara, S. Takasuga, M. Nishio, K. Mizuno, T. Wada, et al.
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}
J. Exp. Med., March 21, 2005; 201(6): 859 - 870.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
E. Tchougounova, A. Lundequist, I. Fajardo, J.-O. Winberg, M. Abrink, and G. Pejler
A Key Role for Mast Cell Chymase in the Activation of Pro-matrix Metalloprotease-9 and Pro-matrix Metalloprotease-2
J. Biol. Chem., March 11, 2005; 280(10): 9291 - 9296.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
R. Hepp, N. Puri, A. C. Hohenstein, G. L. Crawford, S. W. Whiteheart, and P. A. Roche
Phosphorylation of SNAP-23 Regulates Exocytosis from Mast Cells
J. Biol. Chem., February 25, 2005; 280(8): 6610 - 6620.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
H. M. Cherwinski, C. A. Murphy, B. L. Joyce, M. E. Bigler, Y. S. Song, S. M. Zurawski, M. M. Moshrefi, D. M. Gorman, K. L. Miller, S. Zhang, et al.
The CD200 Receptor Is a Novel and Potent Regulator of Murine and Human Mast Cell Function
J. Immunol., February 1, 2005; 174(3): 1348 - 1356.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
M. Neeft, M. Wieffer, A. S. de Jong, G. Negroiu, C. H.G. Metz, A. van Loon, J. Griffith, J. Krijgsveld, N. Wulffraat, H. Koch, et al.
Munc13-4 Is an Effector of Rab27a and Controls Secretion of Lysosomes in Hematopoietic Cells
Mol. Biol. Cell, February 1, 2005; 16(2): 731 - 741.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. Kempna, E. Reiter, M. Arock, A. Azzi, and J.-M. Zingg
Inhibition of HMC-1 Mast Cell Proliferation by Vitamin E: INVOLVEMENT OF THE PROTEIN KINASE B PATHWAY
J. Biol. Chem., December 3, 2004; 279(49): 50700 - 50709.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
R. R. Sivalenka and R. Jessberger
SWAP-70 Regulates c-kit-Induced Mast Cell Activation, Cell-Cell Adhesion, and Migration
Mol. Cell. Biol., December 1, 2004; 24(23): 10277 - 10288.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Matsumoto, Y. Inoue, K. Tsuchiya, T. Shimada, and T. Aikawa
Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R969 - R980.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. Abrink, M. Grujic, and G. Pejler
Serglycin Is Essential for Maturation of Mast Cell Secretory Granule
J. Biol. Chem., September 24, 2004; 279(39): 40897 - 40905.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
I. Couillin, I. Maillet, B. B. Vargaftig, M. Jacobs, G. C. Paesen, P. A. Nuttall, J. Lefort, R. Moser, W. Weston-Davies, and B. Ryffel
Arthropod-Derived Histamine-Binding Protein Prevents Murine Allergic Asthma
J. Immunol., September 1, 2004; 173(5): 3281 - 3286.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. Hallgren, S. Backstrom, S. Estrada, M. Thuveson, and G. Pejler
Histidines Are Critical for Heparin-Dependent Activation of Mast Cell Tryptase
J. Immunol., August 1, 2004; 173(3): 1868 - 1875.
[Abstract] [Full Text] [PDF]


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