| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiological Reviews, Vol 77, 805-836, Copyright © 1997 by American Physiological Society
JOURNAL ARTICLE |
J. Stulc
Department of Pharmacology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
There are great interspecies differences in placental structure as well as in permeability properties of the placenta. In all species, however, the placenta behaves like a low-permeability barrier containing specific mechanisms of transcellular transport for minerals and other substrates for fetal growth and metabolism. The minerals that are contained in plasma in low concentrations and that are mainly intracellular or sequestered in bones (K+, Mg2+, Ca2+, phosphate) are transported to the fetus actively. The transfer of the main extracellular ions, Na+ and Cl-, exhibit great interspecies differences. In the sheep, the transfer rates of Na+ and Cl- to the fetus are consistent with passive transfer mechanisms. In the rat, Na+ is transported to the fetus actively and the transfer of Cl- is facilitated by a carrier and/or a channel. Transfer of minerals to the fetus is controlled by a variety of mechanisms ranging from very simple ones depending on intrinsic properties of the transport systems to complex mechanisms of hormonal control. Water is presumed to move across the placenta passively. The transfer may be facilitated by the 28-kDa water channel-forming integral protein (CHIP28), which is expressed in the trophoblast syncytium.
This article has been cited by other articles:
|
|
 |
|
  D. D Vandre, W. E Ackerman IV, D. A Kniss, A. K Tewari, M. Mori, T. Takizawa, and J. M Robinson Dysferlin Is Expressed in Human Placenta But Does Not Associate with Caveolin Biol Reprod, September 1, 2007; 77(3): 533 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Montalbetti, Q. Li, G. A Timpanaro, S. Gonzalez-Perrett, X.-Q. Dai, X.-Z. Chen, and H. F Cantiello Cytoskeletal regulation of calcium-permeable cation channels in the human syncytiotrophoblast: role of gelsolin J. Physiol., July 15, 2005; 566(2): 309 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.M. Driver, S. Rauz, E.A. Walker, M. Hewison, M.D. Kilby, and P.M. Stewart Characterization of human trophoblast as a mineralocorticoid target tissue Mol. Hum. Reprod., December 1, 2003; 9(12): 793 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hamel, D. Mergler, L. Takser, L. Simoneau, and J. Lafond Effects of Low Concentrations of Organochlorine Compounds in Women on Calcium Transfer in Human Placental Syncytiotrophoblast Toxicol. Sci., November 1, 2003; 76(1): 182 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gonzalez-Perrett, M. Batelli, K. Kim, M. Essafi, G. Timpanaro, N. Moltabetti, I. L. Reisin, M. A. Arnaout, and H. F. Cantiello Voltage Dependence and pH Regulation of Human Polycystin-2-mediated Cation Channel Activity J. Biol. Chem., July 5, 2002; 277(28): 24959 - 24966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Arturi, L. Lacroix, I. Presta, D. Scarpelli, B. Caillou, M. Schlumberger, D. Russo, J.-M. Bidart, and S. Filetti Regulation by Human Chorionic Gonadotropin of Sodium/Iodide Symporter Gene Expression in the JAr Human Choriocarcinoma Cell Line Endocrinology, June 1, 2002; 143(6): 2216 - 2220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-N. Huang and P. W. Swaan Riboflavin Uptake in Human Trophoblast-Derived BeWo Cell Monolayers: Cellular Translocation and Regulatory Mechanisms J. Pharmacol. Exp. Ther., July 1, 2001; 298(1): 264 - 271. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. W. Lyden, J. M. Robinson, S. Tridandapani, J.-L. Teillaud, S. A. Garber, J. M. Osborne, J. Frey, P. Budde, and C. L. Anderson The Fc Receptor for IgG Expressed in the Villus Endothelium of Human Placenta Is Fc{{gamma}}RIIb2 J. Immunol., March 15, 2001; 166(6): 3882 - 3889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Bidart, L. Lacroix, D. Evain-Brion, B. Caillou, V. Lazar, R. Frydman, D. Bellet, S. Filetti, and M. Schlumberger Expression of Na+/I- Symporter and Pendred Syndrome Genes in Trophoblast Cells J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4367 - 4372. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Johansson, T. Jansson, and T. L. Powell Na+-K+-ATPase is distributed to microvillous and basal membrane of the syncytiotrophoblast in human placenta Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R287 - R294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hirasawa, J. Takeyama, H. Sasano, K. Fukushima, T. Suzuki, Y. Muramatu, A. D. Darnel, C. Kaneko, N. Hiwatashi, T. Toyota, et al. 11{beta}-Hydroxysteroid Dehydrogenase Type II and Mineralocorticoid Receptor in Human Placenta J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 1306 - 1309. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Gonzalez-Perrett, K. Kim, C. Ibarra, A. E. Damiano, E. Zotta, M. Batelli, P. C. Harris, I. L. Reisin, M. A. Arnaout, and H. F. Cantiello From the Cover: Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel PNAS, January 30, 2001; 98(3): 1182 - 1187. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
