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Physiol. Rev. 77: 699-729, 1997;
0031-9333/97 $15.00
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Physiological Reviews, Vol 77, 699-729, Copyright © 1997 by American Physiological Society

JOURNAL ARTICLE

Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions

C. Franzini-Armstrong and F. Protasi
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, USA.

The ryanodine receptor (RyR) is a high-conductance Ca2+ channel of the sarcoplasmic reticulum in muscle and of the endoplasmic reticulum in other cells. In striated muscle fibers, RyRs are responsible for the rapid release of Ca2+ that activates contraction. Ryanodine receptors are complex molecules, with unusually large cytoplasmic domains containing numerous binding sites for agents that control the state of activity of the channel-forming domain of the molecule. Structural considerations indicate that long-range interactions between cytoplasmic and intramembrane domains control channel function. Ryanodine receptors are located in specialized regions of the SR, where they are structurally and functionally associated with other intrinsic proteins and, indirectly, also with the luminal Ca2(+)-binding protein calsequestrin. Activation of RyRs during the early part of the excitation-contraction coupling cascade is initiated by the activity of surface-membrane Ca2+ channels, the dihydropyridine receptors (DHPRs). Skeletal and cardiac muscles contain different RyR and DHPR isoforms and both contribute to the diversity in cardiac and skeletal excitation-contraction coupling mechanisms. The architecture of the sarcoplasmic reticulum-surface junctions determines the types of RyR-DHPR interactions in the two muscle types.


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D. W. Shin, Z. Pan, E. K. Kim, J. M. Lee, M. B. Bhat, J. Parness, D. H. Kim, and J. Ma
A Retrograde Signal from Calsequestrin for the Regulation of Store-operated Ca2+ Entry in Skeletal Muscle
J. Biol. Chem., January 24, 2003; 278(5): 3286 - 3292.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
L. A Blatter, J. Kockskamper, K. A Sheehan, A. V Zima, J. Huser, and S. L Lipsius
Local calcium gradients during excitation-contraction coupling and alternans in atrial myocytes
J. Physiol., January 1, 2003; 546(1): 19 - 31.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
G. G. Du, B. Sandhu, V. K. Khanna, X. H. Guo, and D. H. MacLennan
Topology of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (RyR1)
PNAS, December 24, 2002; 99(26): 16725 - 16730.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
R. V. L. Papineni, K. M. S. O'Connell, H. Zhang, R. T. Dirksen, and S. L. Hamilton
Suramin Interacts with the Calmodulin Binding Site on the Ryanodine Receptor, RYR1
J. Biol. Chem., December 13, 2002; 277(51): 49167 - 49174.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
B. Xiao, H. Masumiya, D. Jiang, R. Wang, Y. Sei, L. Zhang, T. Murayama, Y. Ogawa, F. A. Lai, T. Wagenknecht, et al.
Isoform-dependent Formation of Heteromeric Ca2+ Release Channels (Ryanodine Receptors)
J. Biol. Chem., October 25, 2002; 277(44): 41778 - 41785.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
D. Jiang, B. Xiao, L. Zhang, and S.R. W. Chen
Enhanced Basal Activity of a Cardiac Ca2+ Release Channel (Ryanodine Receptor) Mutant Associated With Ventricular Tachycardia and Sudden Death
Circ. Res., August 9, 2002; 91(3): 218 - 225.
[Abstract] [Full Text] [PDF]

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 Mol. Pharmacol.Home page
M. S. Kapiloff
Contributions of Protein Kinase A Anchoring Proteins to Compartmentation of cAMP Signaling in the Heart
Mol. Pharmacol., August 1, 2002; 62(2): 193 - 199.
[Abstract] [Full Text] [PDF]

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 J Am Coll CardiolHome page
B. Bauce, A. Rampazzo, C. Basso, A. Bagattin, L. Daliento, N. Tiso, P. Turrini, G. Thiene, G. A. Danieli, and A. Nava
Screening for ryanodine receptor type 2 mutations in families with effort-induced polymorphic ventricular arrhythmias and sudden death: Early diagnosis of asymptomatic carriers
J. Am. Coll. Cardiol., July 17, 2002; 40(2): 341 - 349.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
D. Rossi, I. Simeoni, M. Micheli, M. Bootman, P. Lipp, P. D. Allen, and V. Sorrentino
RyR1 and RyR3 isoforms provide distinct intracellular Ca2+ signals in HEK 293 cells
J. Cell Sci., June 15, 2002; 115(12): 2497 - 2504.
[Abstract] [Full Text] [PDF]

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 J. Appl. Physiol.Home page
K. Culligan, N. Banville, P. Dowling, and K. Ohlendieck
Drastic reduction of calsequestrin-like proteins and impaired calcium binding in dystrophic mdx muscle
J Appl Physiol, February 1, 2002; 92(2): 435 - 445.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
B. Hinkle, B. Slepchenko, M. M. Rolls, T. C. Walther, P. A. Stein, L. M. Mehlmann, J. Ellenberg, and M. Terasaki
Chromosomal association of Ran during meiotic and mitotic divisions
J. Cell Sci., January 12, 2002; 115(23): 4685 - 4693.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
G. Bultynck, D. Rossi, G. Callewaert, L. Missiaen, V. Sorrentino, J. B. Parys, and H. De Smedt
The Conserved Sites for the FK506-binding Proteins in Ryanodine Receptors and Inositol 1,4,5-Trisphosphate Receptors Are Structurally and Functionally Different
J. Biol. Chem., December 7, 2001; 276(50): 47715 - 47724.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
W. G Kirsch, D. Uttenweiler, and R. H A Fink
Spark- and ember-like elementary Ca2+ release events in skinned fibres of adult mammalian skeletal muscle
J. Physiol., December 1, 2001; 537(2): 379 - 389.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
H. Masumiya, P. Li, L. Zhang, and S. R. W. Chen
Ryanodine Sensitizes the Ca2+ Release Channel (Ryanodine Receptor) to Ca2+ Activation
J. Biol. Chem., October 19, 2001; 276(43): 39727 - 39735.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
S. Chawla, J. N Skepper, A. R Hockaday, and C. L-H Huang
Calcium waves induced by hypertonic solutions in intact frog skeletal muscle fibres
J. Physiol., October 15, 2001; 536(2): 351 - 359.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
A. M. Duke and D. S. Steele
Mechanisms of reduced SR Ca2+ release induced by inorganic phosphate in rat skeletal muscle fibers
Am J Physiol Cell Physiol, August 1, 2001; 281(2): C418 - C429.
[Abstract] [Full Text] [PDF]

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 J. Appl. Physiol.Home page
C. M. Pabelick, G. C. Sieck, and Y. S. Prakash
Signal Transduction in Smooth Muscle: Invited Review: Significance of spatial and temporal heterogeneity of calcium transients in smooth muscle
J Appl Physiol, July 1, 2001; 91(1): 488 - 496.
[Abstract] [Full Text] [PDF]

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 Physiol. Rev.Home page
V. Bennett and A. J. Baines
Spectrin and Ankyrin-Based Pathways: Metazoan Inventions for Integrating Cells Into Tissues
Physiol Rev, July 1, 2001; 81(3): 1353 - 1392.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
H. Takekura, N. Fujinami, T. Nishizawa, H. Ogasawara, and N. Kasuga
Eccentric exercise-induced morphological changes in the membrane systems involved in excitation-contraction coupling in rat skeletal muscle
J. Physiol., June 1, 2001; 533(2): 571 - 583.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
C. L-H Huang
Charge movements in intact amphibian skeletal muscle fibres in the presence of cardiac glycosides
J. Physiol., April 15, 2001; 532(2): 509 - 523.
[Abstract] [Full Text] [PDF]

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 J. Histochem. Cytochem.Home page
H. Ueda, K. Ueda, T. Baba, and S. Ohno
{{delta}}- and {{gamma}}-Sarcoglycan Localization in the Sarcoplasmic Reticulum of Skeletal Muscle
J. Histochem. Cytochem., April 1, 2001; 49(4): 529 - 538.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
G. Avila, J. J. O'Brien, and R. T. Dirksen
Excitation-contraction uncoupling by a human central core disease mutation in the ryanodine receptor
PNAS, March 27, 2001; 98(7): 4215 - 4220.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
H. H. Valdivia
Cardiac Ryanodine Receptors and Accessory Proteins: Augmented Expression Does Not Necessarily Mean Big Function
Circ. Res., February 2, 2001; 88(2): 134 - 136.
[Full Text] [PDF]

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 CirculationHome page
L. Zhao, A. Sebkhi, D. J. R. Nunez, L. Long, C. S. Haley, J. Szpirer, C. Szpirer, A. J. Williams, and M. R. Wilkins
Right Ventricular Hypertrophy Secondary to Pulmonary Hypertension Is Linked to Rat Chromosome 17 : Evaluation of Cardiac Ryanodine Ryr2 Receptor as a Candidate
Circulation, January 23, 2001; 103(3): 442 - 447.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
M. S. Kapiloff, N. Jackson, and N. Airhart
mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope
J. Cell Sci., January 9, 2001; 114(17): 3167 - 3176.
[Abstract] [Full Text] [PDF]

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 PhysiologyHome page
S. L. Hamilton, I. Serysheva, and G. M. Strasburg
Calmodulin and Excitation-Contraction Coupling
Physiology, December 1, 2000; 15(6): 281 - 284.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Morrissette, L. Xu, A. Nelson, G. Meissner, and B. A. Block
Characterization of RyR1-slow, a ryanodine receptor specific to slow-twitch skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2000; 279(5): R1889 - R1898.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Ryan, K. W. Gross, and G. Hajduczok
Calcium-dependent activation of phospholipase C by mechanical distension in renin-expressing As4.1 cells
Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E823 - E829.
[Abstract] [Full Text] [PDF]


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