Physiol Rev AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 77: 627-641, 1997;
0031-9333/97 $15.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaczmarek, L. K.
Right arrow Articles by Blumenthal, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaczmarek, L. K.
Right arrow Articles by Blumenthal, E. M.

Physiological Reviews, Vol 77, 627-641, Copyright © 1997 by American Physiological Society

JOURNAL ARTICLE

Properties and regulation of the minK potassium channel protein

L. K. Kaczmarek and E. M. Blumenthal
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.

The minK gene encodes a protein of 130 amino acids that has a single transmembrane segment and is expressed in many tissues including heart, uterus, and kidney. When Xenopus oocytes are injected with minK mRNA, a very slowly activating voltage-dependent potassium current is induced in these cells. The induced channels appear to result from the interaction of the minK protein with other channel-forming subunits such as the KvLQT1 channel. The minK protein is intimately associated with the structure of the resultant channels, and mutations in minK can alter ion selectivity and modulation by second messengers. Strong candidates for native currents regulated by the minK protein include the slow component of the cardiac delayed rectifier and potassium currents recorded across epithelial cells in vestibular organs and cochlea.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
K. W. Dilly, J. Kurokawa, C. Terrenoire, S. Reiken, W. J. Lederer, A. R. Marks, and R. S. Kass
Overexpression of {beta}2-Adrenergic Receptors cAMP-dependent Protein Kinase Phosphorylates and Modulates Slow Delayed Rectifier Potassium Channels Expressed in Murine Heart: EVIDENCE FOR RECEPTOR/CHANNEL CO-LOCALIZATION
J. Biol. Chem., September 24, 2004; 279(39): 40778 - 40787.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Lewis, Z. A. McCrossan, and G. W. Abbott
MinK, MiRP1, and MiRP2 Diversify Kv3.1 and Kv3.2 Potassium Channel Gating
J. Biol. Chem., February 27, 2004; 279(9): 7884 - 7892.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
G. W. ABBOTT and S. A. N. GOLDSTEIN
Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism
FASEB J, March 1, 2002; 16(3): 390 - 400.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. Franco, S. Demolombe, S. Kupershmidt, R. Dumaine, J. N Dominguez, D. Roden, C. Antzelevitch, D. Escande, and A. F.M Moorman
Divergent expression of delayed rectifier K+ channel subunits during mouse heart development
Cardiovasc Res, October 1, 2001; 52(1): 65 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
G. W. Abbott and S. A. N. Goldstein
Potassium Channel Subunits: The MiRP Family
Mol. Interv., June 1, 2001; 1(2): 95 - 107.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Abriel, H. Motoike, and R. S. Kass
KChAP: a novel chaperone for specific K+ channels key to repolarization of the cardiac action potential. Focus on "KChAP as a chaperone for specific K+ channels"
Am J Physiol Cell Physiol, May 1, 2000; 278(5): C863 - C864.
[Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. Lehmann-Horn and K. Jurkat-Rott
Voltage-Gated Ion Channels and Hereditary Disease
Physiol Rev, October 1, 1999; 79(4): 1317 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release
Physiol Rev, July 1, 1999; 79(3): 1019 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Jaques, Y.-K. Kim, and L. L. McCarter
Mutations conferring resistance to phenamil and amiloride, inhibitors of sodium-driven motility of Vibrio parahaemolyticus
PNAS, May 11, 1999; 96(10): 5740 - 5745.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Wang, J. Xia, and R. S. Kass
MinK-KvLQT1 Fusion Proteins, Evidence for Multiple Stoichiometries of the Assembled IsK Channel
J. Biol. Chem., December 18, 1998; 273(51): 34069 - 34074.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. F. Lo and R. Numann
Independent and Exclusive Modulation of Cardiac Delayed Rectifying K+ Current by Protein Kinase C and Protein Kinase A
Circ. Res., November 16, 1998; 83(10): 995 - 1002.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Kathofer, W. Zhang, C. Karle, D. Thomas, W. Schoels, and J. Kiehn
Functional Coupling of Human beta 3-Adrenoreceptors to the KvLQT1/MinK Potassium Channel
J. Biol. Chem., August 25, 2000; 275(35): 26743 - 26747.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
G. Yue, D. Merlin, M. E. Selsted, W. I. Lencer, J. L. Madara, and D. C. Eaton
Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells
Am J Physiol Gastrointest Liver Physiol, May 1, 2002; 282(5): G757 - G765.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online