Physiol Rev AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 77: 359-396, 1997;
0031-9333/97 $15.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Garty, H.
Right arrow Articles by Palmer, L. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Garty, H.
Right arrow Articles by Palmer, L. G.

Physiological Reviews, Vol 77, 359-396, Copyright © 1997 by American Physiological Society

JOURNAL ARTICLE

Epithelial sodium channels: function, structure, and regulation

H. Garty and L. G. Palmer
Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.

The apical (outward-facing) membranes of high-resistance epithelia contain Na+ channels, traditionally identified by their sensitivity to block by the K(+)-sparing diuretic amiloride. Such channels have been characterized in amphibian skin and urinary bladder, renal collecting duct, distal colon, sweat and salivary glands, lung, and taste buds. They mediate the first step of active Na+ reabsorption and play a major role in the maintenance of electrolyte and water homeostasis in all vertebrates. In the past, these channels were classified according to their biophysical and pharmacological properties. The recent cloning of the three homologous channel subunits denoted alpha-, beta-, and gamma-epithelial Na+ channels (ENaC) has provided a molecular definition of at least one class of amiloride-blockable channels. Subsequent studies have established that ENaC is a major Na(+)-conducting pathway in both absorbing and secretory epithelia and is related to one type of channel involved in mechanosensation. This review summarizes the biophysical characteristics, molecular properties, and regulatory mechanisms of epithelial amiloride-blockable Na+ channels. Special emphasis is given to recent studies utilizing cloned ENaC subunits and purified amiloride-binding proteins.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
K. K. Knight, D. M. Wentzlaff, and P. M. Snyder
Intracellular Sodium Regulates Proteolytic Activation of the Epithelial Sodium Channel
J. Biol. Chem., October 10, 2008; 283(41): 27477 - 27482.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Liang, M. B. Butterworth, K. W. Peters, W. H. Walker, and R. A. Frizzell
An Obligatory Heterodimer of 14-3-3{beta} and 14-3-3{epsilon} Is Required for Aldosterone Regulation of the Epithelial Sodium Channel
J. Biol. Chem., October 10, 2008; 283(41): 27418 - 27425.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
V. Bhalla and K. R. Hallows
Mechanisms of ENaC Regulation and Clinical Implications
J. Am. Soc. Nephrol., October 1, 2008; 19(10): 1845 - 1854.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Nesterov, A. Dahlmann, M. Bertog, and C. Korbmacher
Trypsin can activate the epithelial sodium channel (ENaC) in microdissected mouse distal nephron
Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1052 - F1062.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Bugaj, O. Pochynyuk, E. Mironova, A. Vandewalle, J. L. Medina, and J. D. Stockand
Regulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct
Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1063 - F1070.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Diakov, K. Bera, M. Mokrushina, B. Krueger, and C. Korbmacher
Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels
J. Physiol., October 1, 2008; 586(19): 4587 - 4608.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
O. J. Mace, A. M. Woollhead, and D. L. Baines
AICAR activates AMPK and alters PIP2 association with the epithelial sodium channel ENaC to inhibit Na+ transport in H441 lung epithelial cells
J. Physiol., September 15, 2008; 586(18): 4541 - 4557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. P. Shi, X. R. Cao, E. M. Sweezer, T. S. Kinney, N. R. Williams, R. F. Husted, R. Nair, R. M. Weiss, R. A. Williamson, C. D. Sigmund, et al.
Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2
Am J Physiol Renal Physiol, August 1, 2008; 295(2): F462 - F470.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
G. Frindt, Z. Ergonul, and L. G. Palmer
Surface Expression of Epithelial Na Channel Protein in Rat Kidney
J. Gen. Physiol., May 26, 2008; 131(6): 617 - 627.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
H. O'Neill, J. Lebeck, P. B. Collins, T.-H. Kwon, J. Frokiaer, and S. Nielsen
Aldosterone-mediated apical targeting of ENaC subunits is blunted in rats with streptozotocin-induced diabetes mellitus
Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1546 - 1555.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. M. Myerburg, E. E. McKenna, C. J. Luke, R. A. Frizzell, T. R. Kleyman, and J. M. Pilewski
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis
Am J Physiol Lung Cell Mol Physiol, May 1, 2008; 294(5): L932 - L941.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. J. Bedford, J. P. Leader, R. Jing, L. J. Walker, J. D. Klein, J. M. Sands, and R. J. Walker
Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus
Am J Physiol Renal Physiol, April 1, 2008; 294(4): F812 - F820.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
B. Edemir, S. Reuter, R. Borgulya, R. Schroter, U. Neugebauer, G. Gabriels, and E. Schlatter
Acute Rejection Modulates Gene Expression in the Collecting Duct
J. Am. Soc. Nephrol., March 1, 2008; 19(3): 538 - 546.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
O. Frohlich, D. Aggarwal, J. D. Klein, K. J. Kent, Y. Yang, R. B. Gunn, and J. M. Sands
Stimulation of UT-A1-mediated transepithelial urea flux in MDCK cells by lithium
Am J Physiol Renal Physiol, March 1, 2008; 294(3): F518 - F524.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Bertog, J. E. Cuffe, S. Pradervand, E. Hummler, A. Hartner, M. Porst, K. F. Hilgers, B. C. Rossier, and C. Korbmacher
Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome
J. Physiol., January 15, 2008; 586(2): 459 - 475.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
O. Pochynyuk, V. Bugaj, A. Vandewalle, and J. D. Stockand
Purinergic control of apical plasma membrane PI(4,5)P2 levels sets ENaC activity in principal cells
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F38 - F46.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Taruno, N. Niisato, and Y. Marunaka
Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F177 - F186.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
A. Adebamiro, Y. Cheng, U. S. Rao, H. Danahay, and R. J. Bridges
A Segment of {gamma} ENaC Mediates Elastase Activation of Na+ Transport
J. Gen. Physiol., November 26, 2007; 130(6): 611 - 629.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Li, S. Koshy, and H. G. Folkesson
Involvement of {alpha}ENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis
Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L1069 - L1078.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Bize and J.-D. Horisberger
Sodium self-inhibition of human epithelial sodium channel: selectivity and affinity of the extracellular sodium sensing site
Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1137 - F1146.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Jin, Z. Wang, Y. Zhang, B. Yang, and W.-H. Wang
PGE2 inhibits apical K channels in the CCD through activation of the MAPK pathway
Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1299 - F1307.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
O. Pochynyuk, Q. Tong, J. Medina, A. Vandewalle, A. Staruschenko, V. Bugaj, and J. D. Stockand
Molecular Determinants of PI(4,5)P2 and PI(3,4,5)P3 Regulation of the Epithelial Na+ Channel
J. Gen. Physiol., September 24, 2007; 130(4): 399 - 413.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. O. Wielputz, I.-H. Lee, A. Dinudom, S. Boulkroun, N. Farman, D. I. Cook, C. Korbmacher, and R. Rauh
(NDRG2) Stimulates Amiloride-sensitive Na+ Currents in Xenopus laevis Oocytes and Fisher Rat Thyroid Cells
J. Biol. Chem., September 21, 2007; 282(38): 28264 - 28273.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. B. Kashlan, G. M. Mueller, M. Z. Qamar, P. A. Poland, A. Ahner, R. C. Rubenstein, R. P. Hughey, J. L. Brodsky, and T. R. Kleyman
Small Heat Shock Protein {alpha}A-crystallin Regulates Epithelial Sodium Channel Expression
J. Biol. Chem., September 21, 2007; 282(38): 28149 - 28156.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
R. A. Falin and C. U. Cotton
Acute Downregulation of ENaC by EGF Involves the PY Motif and Putative ERK Phosphorylation Site
J. Gen. Physiol., August 27, 2007; 130(3): 313 - 328.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Boyd and A. Naray-Fejes-Toth
Steroid-Mediated Regulation of the Epithelial Sodium Channel Subunits in Mammary Epithelial Cells
Endocrinology, August 1, 2007; 148(8): 3958 - 3967.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. Althaus, R. Bogdan, W. G. Clauss, and M. Fronius
Mechano-sensitivity of epithelial sodium channels (ENaCs): laminar shear stress increases ion channel open probability
FASEB J, August 1, 2007; 21(10): 2389 - 2399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Yu, D. C. Eaton, and M. N. Helms
Effect of divalent heavy metals on epithelial Na+ channels in A6 cells
Am J Physiol Renal Physiol, July 1, 2007; 293(1): F236 - F244.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. M. Snyder, K. C. Beck, S. T. Turner, E. A. Hoffman, M. J. Joyner, and B. D. Johnson
Genetic variation of the beta2-adrenergic receptor is associated with differences in lung fluid accumulation in humans
J Appl Physiol, June 1, 2007; 102(6): 2172 - 2178.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. Staruschenko, O. Pochynyuk, A. Vandewalle, V. Bugaj, and J. D. Stockand
Acute Regulation of the Epithelial Na+ Channel by Phosphatidylinositide 3-OH Kinase Signaling in Native Collecting Duct Principal Cells
J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1652 - 1661.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
O. Pochynyuk, Q. Tong, A. Staruschenko, and J. D. Stockand
Binding and direct activation of the epithelial Na+ channel (ENaC) by phosphatidylinositides
J. Physiol., April 15, 2007; 580(2): 365 - 372.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. Bengrine, J. Li, and M. S. Awayda
The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel
FASEB J, April 1, 2007; 21(4): 1189 - 1201.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Frindt, Z. Ergonul, and L. G. Palmer
Na channel expression and activity in the medullary collecting duct of rat kidney
Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1190 - F1196.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. W. Good
Nongenomic Actions of Aldosterone on the Renal Tubule
Hypertension, April 1, 2007; 49(4): 728 - 739.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. A. Tobey, C. M. Argote, M. S. Awayda, X. C. Vanegas, and R. C. Orlando
Effect of luminal acidity on the apical cation channel in rabbit esophageal epithelium
Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G796 - G805.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
Y. Bobkov and B. Ache
Block by Amiloride Derivatives of Odor-Evoked Discharge in Lobster Olfactory Receptor Neurons through Action on a Presumptive TRP Channel
Chem Senses, February 1, 2007; 32(2): 149 - 159.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
A. L. Brown, S. M. Fernandez-Illescas, Z. Liao, and M. B. Goodman
Gain-of-Function Mutations in the MEC-4 DEG/ENaC Sensory Mechanotransduction Channel Alter Gating and Drug Blockade
J. Gen. Physiol., January 29, 2007; 129(2): 161 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Nielsen, T.-H. Kwon, J. Frokiaer, M. A. Knepper, and S. Nielsen
Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade
Am J Physiol Renal Physiol, January 1, 2007; 292(1): F382 - F394.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Li, Z. Wang, P. Sun, Y. Jin, D.-H. Lin, S. C. Hebert, G. Giebisch, and W.-H. Wang
Inhibition of MAPK stimulates the Ca2+-dependent big-conductance K channels in cortical collecting duct
PNAS, December 19, 2006; 103(51): 19569 - 19574.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Su, Q. Li, K. Shrestha, E. Cormet-Boyaka, L. Chen, P. R. Smith, E. J. Sorscher, D. J. Benos, S. Matalon, and H.-L. Ji
Interregulation of Proton-gated Na+ Channel 3 and Cystic Fibrosis Transmembrane Conductance Regulator
J. Biol. Chem., December 1, 2006; 281(48): 36960 - 36968.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. C. Grifoni, K. P. Gannon, D. E. Stec, and H. A. Drummond
ENaC proteins contribute to VSMC migration
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H3076 - H3086.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. Sun, D.-H. Lin, T. Wang, E. Babilonia, Z. Wang, Y. Jin, R. Kemp, A. Nasjletti, and W.-H. Wang
Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1192 - F1200.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. L. Jernigan and H. A. Drummond
Myogenic vasoconstriction in mouse renal interlobar arteries: role of endogenous beta and {gamma}ENaC
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1184 - F1191.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Mazzochi, D. J. Benos, and P. R. Smith
Interaction of epithelial ion channels with the actin-based cytoskeleton
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1113 - F1122.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. B. Kashlan, A. B. Maarouf, C. Kussius, R. M. Denshaw, K. M. Blumenthal, and T. R. Kleyman
Distinct Structural Elements in the First Membrane-spanning Segment of the Epithelial Sodium Channel
J. Biol. Chem., October 13, 2006; 281(41): 30455 - 30462.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. J. Page and E. Di Cera
Role of na+ and k+ in enzyme function.
Physiol Rev, October 1, 2006; 86(4): 1049 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. Pochynyuk, J. Medina, N. Gamper, H. Genth, J. D. Stockand, and A. Staruschenko
Rapid Translocation and Insertion of the Epithelial Na+ Channel in Response to RhoA Signaling
J. Biol. Chem., September 8, 2006; 281(36): 26520 - 26527.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Bhalla, N. M. Oyster, A. C. Fitch, M. A. Wijngaarden, D. Neumann, U. Schlattner, D. Pearce, and K. R. Hallows
AMP-activated Kinase Inhibits the Epithelial Na+ Channel through Functional Regulation of the Ubiquitin Ligase Nedd4-2
J. Biol. Chem., September 8, 2006; 281(36): 26159 - 26169.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Z. Ergonul, G. Frindt, and L. G. Palmer
Regulation of maturation and processing of ENaC subunits in the rat kidney
Am J Physiol Renal Physiol, September 1, 2006; 291(3): F683 - F693.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Anantharam, Y. Tian, and L. G. Palmer
Open probability of the epithelial sodium channel is regulated by intracellular sodium
J. Physiol., July 15, 2006; 574(2): 333 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
X. R. Cao, P. P. Shi, R. D. Sigmund, R. F. Husted, C. D. Sigmund, R. A. Williamson, J. B. Stokes, and B. Yang
Mice heterozygous for beta-ENaC deletion have defective potassium excretion
Am J Physiol Renal Physiol, July 1, 2006; 291(1): F107 - F115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. Malik, S. R. Price, W. E. Mitch, Q. Yue, and D. C. Eaton
Regulation of epithelial sodium channels by the ubiquitin-proteasome proteolytic pathway
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1285 - F1294.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Sheng, M. D. Carattino, J. B. Bruns, R. P. Hughey, and T. R. Kleyman
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1488 - F1496.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
O. Pochynyuk, Q. Tong, A. Staruschenko, H.-P. Ma, and J. D. Stockand
Regulation of the epithelial Na+ channel (ENaC) by phosphatidylinositides
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F949 - F957.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Wei, P. Sun, Z. Wang, B. Yang, M. A. Carroll, and W.-H. Wang
Adenosine inhibits ENaC via cytochrome P-450 epoxygenase-dependent metabolites of arachidonic acid
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1163 - F1168.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L.-M. Yang, R. Rinke, and C. Korbmacher
Stimulation of the Epithelial Sodium Channel (ENaC) by cAMP Involves Putative ERK Phosphorylation Sites in the C Termini of the Channel's beta- and {gamma}-Subunit
J. Biol. Chem., April 14, 2006; 281(15): 9859 - 9868.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. S. Edinger, J. Yospin, C. Perry, T. R. Kleyman, and J. P. Johnson
Regulation of Epithelial Na+ Channels (ENaC) by Methylation: A NOVEL METHYLTRANSFERASE STIMULATES ENaC ACTIVITY
J. Biol. Chem., April 7, 2006; 281(14): 9110 - 9117.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. N. Helms, X.-J. Chen, S. Ramosevac, D. C. Eaton, and L. Jain
Dopamine regulation of amiloride-sensitive sodium channels in lung cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L710 - L722.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-L. Ji, X.-F. Su, S. Kedar, J. Li, P. Barbry, P. R. Smith, S. Matalon, and D. J. Benos
{delta}-Subunit Confers Novel Biophysical Features to {alpha}beta{gamma}-Human Epithelial Sodium Channel (ENaC) via a Physical Interaction
J. Biol. Chem., March 24, 2006; 281(12): 8233 - 8241.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Yamamuro, M. Yoshimura, M. Nakayama, K. Abe, M. Shono, S. Suzuki, T. Sakamoto, Y. Saito, K. Nakao, H. Yasue, et al.
Direct Effects of Aldosterone on Cardiomyocytes in the Presence of Normal and Elevated Extracellular Sodium
Endocrinology, March 1, 2006; 147(3): 1314 - 1321.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
B. Pelucchi, G. Aguiari, A. Pignatelli, E. Manzati, R. Witzgall, L. del Senno, and O. Belluzzi
Nonspecific Cation Current Associated with Native Polycystin-2 in HEK-293 Cells
J. Am. Soc. Nephrol., February 1, 2006; 17(2): 388 - 397.
[Abstract] [Full Text] [PDF]