Physiol Rev Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 76: 1005-1026, 1996;
0031-9333/96 $15.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stewart, C. E.
Right arrow Articles by Rotwein, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stewart, C. E.
Right arrow Articles by Rotwein, P.

Physiological Reviews, Vol 76, 1005-1026, Copyright © 1996 by American Physiological Society

JOURNAL ARTICLE

Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors

C. E. Stewart and P. Rotwein
Department of Biochemistry, Washington University School of Medicine, Saint Louis, Missouri, USA.

The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a conserved pair of secreted proteins with diverse effects on growth, development, and metabolism. Insulin-like growth factor action is initiated upon binding to cell-surface receptors and is modulated through interactions with secreted IGF binding proteins (IGFBPs). The last decade has seen an explosion of new information about the physiological roles of the IGFs. In this review, we critically examine this information from biochemical, cell biological, and molecular genetic perspectives. We discuss the structures and functions of the two IGF receptors, outline the actions of the six IGFBPs, and summarize and interpret recent studies highlighting essential roles for components of the IGF system in the growth and development of the embryo and fetus, in tissue differentiation, in cell survival and proliferation, and in cancer. These results are discussed in the context of new opportunities for understanding the mechanisms of IGF action in multiple biological processes.


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. J. Vatten, J. M. Holly, D. Gunnell, and S. Tretli
Nested Case-Control Study of the Association of Circulating Levels of Serum Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 with Breast Cancer in Young Women in Norway
Cancer Epidemiol. Biomarkers Prev., August 1, 2008; 17(8): 2097 - 2100.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
R. Masnikosa, A. Nikolic, and O. Nedic
Affinity Modulation of Human Placental Insulin and Insulin-Like Growth Factor Receptors by Lectins
J. Biochem., June 1, 2008; 143(6): 813 - 820.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Ning, A. G. P. Schuller, C. A. Conover, and J. E. Pintar
Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activity in Vivo
Mol. Endocrinol., May 1, 2008; 22(5): 1213 - 1225.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Eleswarapu, Z. Gu, and H. Jiang
Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression May Be Mediated by Multiple Distal Signal Transducer and Activator of Transcription 5 Binding Sites
Endocrinology, May 1, 2008; 149(5): 2230 - 2240.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
Y. Hu, R. Tan, C. D. MacCalman, G. Eastabrook, S.-H. Park, J. P. Dutz, and P. von Dadelszen
IFN-{gamma}-mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: a role for insulin-like growth factors
Mol. Hum. Reprod., May 1, 2008; 14(5): 281 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Liao, X. Chen, S. Wang, A. F. Parlow, and J. Xu
Steroid Receptor Coactivator 3 Maintains Circulating Insulin-Like Growth Factor I (IGF-I) by Controlling IGF-Binding Protein 3 Expression
Mol. Cell. Biol., April 1, 2008; 28(7): 2460 - 2469.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. A. Kaplan and P. Cohen
REVIEW: The Somatomedin Hypothesis 2007: 50 Years Later
J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4529 - 4535.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. D. Hand, M. C. Kostek, R. E. Ferrell, M. J. Delmonico, L. W. Douglass, S. M. Roth, J. M. Hagberg, and B. F. Hurley
Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults
J Appl Physiol, November 1, 2007; 103(5): 1678 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. I. Lewis, M. Fournier, T. W. Storer, S. Bhasin, J. Porszasz, S.-G. Ren, X. Da, and R. Casaburi
Skeletal muscle adaptations to testosterone and resistance training in men with COPD
J Appl Physiol, October 1, 2007; 103(4): 1299 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
D. Spentzos, S. A Cannistra, F. Grall, D. A Levine, K. Pillay, T. A Libermann, and C. S Mantzoros
IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer
Endocr. Relat. Cancer, September 1, 2007; 14(3): 781 - 790.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. D. R. Harridge
Plasticity of human skeletal muscle: gene expression to in vivo function
Exp Physiol, September 1, 2007; 92(5): 783 - 797.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Jiang, Y. Wang, M. Wu, Z. Gu, S. J. Frank, and R. Torres-Diaz
Growth Hormone Stimulates Hepatic Expression of Bovine Growth Hormone Receptor Messenger Ribonucleic Acid through Signal Transducer and Activator of Transcription 5 Activation of a Major Growth Hormone Receptor Gene Promoter
Endocrinology, July 1, 2007; 148(7): 3307 - 3315.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Ning, B. Hoang, A. G. P. Schuller, T. P. Cominski, M.-S. Hsu, T. L. Wood, and J. E. Pintar
Delayed Mammary Gland Involution in Mice with Mutation of the Insulin-Like Growth Factor Binding Protein 5 Gene
Endocrinology, May 1, 2007; 148(5): 2138 - 2147.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
J. W. Lu, J. P. McMurtry, and C. N. Coon
Developmental Changes of Plasma Insulin, Glucagon, Insulin-like Growth Factors, Thyroid Hormones, and Glucose Concentrations in Chick Embryos and Hatched Chicks
Poult. Sci., April 1, 2007; 86(4): 673 - 683.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Moerth, M. R. Schneider, I. Renner-Mueller, A. Blutke, M. W. Elmlinger, R. G. Erben, C. Camacho-Hubner, A. Hoeflich, and E. Wolf
Postnatally Elevated Levels of Insulin-Like Growth Factor (IGF)-II Fail to Rescue the Dwarfism of IGF-I-Deficient Mice except Kidney Weight
Endocrinology, January 1, 2007; 148(1): 441 - 451.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
G. K. Noble, E. Houghton, C. J. Roberts, J. Faustino-Kemp, S. S. de Kock, B. C. Swanepoel, and M. N. Sillence
Effect of exercise, training, circadian rhythm, age, and sex on insulin-like growth factor-1 in the horse
J Anim Sci, January 1, 2007; 85(1): 163 - 171.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
F. Prefumo, S. Canini, A. Crovo, D. Pastorino, P. L. Venturini, and P. De Biasio
Correlation between first trimester fetal bone length and maternal serum pregnancy-associated plasma protein-A (PAPP-A)
Hum. Reprod., November 1, 2006; 21(11): 3019 - 3021.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Liao, R. K. Dearth, S. Zhou, O. L. Britton, A. V. Lee, and J. Xu
Liver-Specific Overexpression of the Insulin-like Growth Factor-I Enhances Somatic Growth and Partially Prevents the Effects of Growth Hormone Deficiency
Endocrinology, August 1, 2006; 147(8): 3877 - 3888.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. S. McLellan, T. Kealey, and K. Langlands
An E box in the exon 1 promoter regulates insulin-like growth factor-I expression in differentiating muscle cells
Am J Physiol Cell Physiol, August 1, 2006; 291(2): C300 - C307.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Castillo, I. Ammendrup-Johnsen, M. Codina, I. Navarro, and J. Gutierrez
IGF-I and insulin receptor signal transduction in trout muscle cells
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1683 - R1690.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
Y. Zhou and H. Jiang
Short Communication: A Milk Trait-Associated Polymorphism in the Bovine Growth Hormone Receptor Gene Does Not Affect Receptor Signaling
J Dairy Sci, May 1, 2006; 89(5): 1761 - 1764.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
E. Colombo, S. G. Giannelli, R. Galli, E. Tagliafico, C. Foroni, E. Tenedini, S. Ferrari, S. Ferrari, G. Corte, A. Vescovi, et al.
Embryonic Stem-Derived Versus Somatic Neural Stem Cells: A Comparative Analysis of Their Developmental Potential and Molecular Phenotype
Stem Cells, April 1, 2006; 24(4): 825 - 834.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
A. Sacco, R. Doyonnas, M. A. LaBarge, M. M. Hammer, P. Kraft, and H. M. Blau
IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors
J. Cell Biol., November 7, 2005; 171(3): 483 - 492.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Zekri, K. Chebli, H. Tourriere, F. C. Nielsen, T. V. O. Hansen, A. Rami, and J. Tazi
Control of Fetal Growth and Neonatal Survival by the RasGAP-Associated Endoribonuclease G3BP
Mol. Cell. Biol., October 1, 2005; 25(19): 8703 - 8716.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Grohmann, E. Foulstone, G. Welsh, J. Holly, J. Shield, E. Crowne, and C. Stewart
Isolation and validation of human prepubertal skeletal muscle cells: maturation and metabolic effects of IGF-I, IGFBP-3 and TNF{alpha}
J. Physiol., October 1, 2005; 568(1): 229 - 242.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
K Iida, C J Rosen, C Ackert-Bicknell, and M O Thorner
Genetic differences in the IGF-I gene among inbred strains of mice with different serum IGF-I levels
J. Endocrinol., September 1, 2005; 186(3): 481 - 489.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
M Elloumi, N El Elj, M Zaouali, F Maso, E Filaire, Z Tabka, and G Lac
IGFBP-3, a sensitive marker of physical training and overtraining
Br. J. Sports Med., September 1, 2005; 39(9): 604 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. L. Shumate, G. Yumet, T. A. Ahmed, and R. N. Cooney
Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes
Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G227 - G239.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. K. Tisi, X.-J. Liu, L. J. Wykes, C. D. Skinner, and K. G. Koski
Insulin-Like Growth Factor II and Binding Proteins 1 and 3 from Second Trimester Human Amniotic Fluid Are Associated with Infant Birth Weight
J. Nutr., July 1, 2005; 135(7): 1667 - 1672.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Ioannidis, L. G. Mahaira, S. A. Perez, A. D. Gritzapis, P. A. Sotiropoulou, G. J. Kavalakis, A. I. Antsaklis, C. N. Baxevanis, and M. Papamichail
CRD-BP/IMP1 Expression Characterizes Cord Blood CD34+ Stem Cells and Affects c-myc and IGF-II Expression in MCF-7 Cancer Cells
J. Biol. Chem., May 20, 2005; 280(20): 20086 - 20093.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, A. D. Rogol, J. C. Lovejoy, M. Sheffield-Moore, N. Mauras, and C. Y. Bowers
Endocrine Control of Body Composition in Infancy, Childhood, and Puberty
Endocr. Rev., February 1, 2005; 26(1): 114 - 146.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Yan, B. E. Forbes, K. A. McNeil, R. C. Baxter, and S. M. Firth
Role of N- and C-terminal Residues of Insulin-like Growth Factor (IGF)-binding Protein-3 in Regulating IGF Complex Formation and Receptor Activation
J. Biol. Chem., December 17, 2004; 279(51): 53232 - 53240.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. Iida, E. Itoh, D.-S. Kim, J. P del Rincon, K. T Coschigano, J. J Kopchick, and M. O Thorner
Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone-deficient lit/lit mice
J. Physiol., October 15, 2004; 560(2): 341 - 349.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
G. Chandrasekher and D. Sailaja
Phosphatidylinositol 3-Kinase (PI-3K)/Akt but Not PI-3K/p70 S6 Kinase Signaling Mediates IGF-1-Promoted Lens Epithelial Cell Survival
Invest. Ophthalmol. Vis. Sci., October 1, 2004; 45(10): 3577 - 3588.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. W. Siddals, E. Marshman, M. Westwood, and J. M. Gibson
Abrogation of Insulin-like Growth Factor-I (IGF-I) and Insulin Action by Mevalonic Acid Depletion: SYNERGY BETWEEN PROTEIN PRENYLATION AND RECEPTOR GLYCOSYLATION PATHWAYS
J. Biol. Chem., September 10, 2004; 279(37): 38353 - 38359.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. B. Boldt, K. Kjaer-Sorensen, M. T. Overgaard, K. Weyer, C. B. Poulsen, L. Sottrup-Jensen, C. A. Conover, L. C. Giudice, and C. Oxvig
The Lin12-Notch Repeats of Pregnancy-associated Plasma Protein-A Bind Calcium and Determine Its Proteolytic Specificity
J. Biol. Chem., September 10, 2004; 279(37): 38525 - 38531.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. DeLellis, S. Rinaldi, R. J. Kaaks, L. N. Kolonel, B. Henderson, and L. Le Marchand
Dietary and Lifestyle Correlates of Plasma Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3): The Multiethnic Cohort
Cancer Epidemiol. Biomarkers Prev., September 1, 2004; 13(9): 1444 - 1451.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L. J. Cobb, D. A. M. Salih, I. Gonzalez, G. Tripathi, E. J. Carter, F. Lovett, C. Holding, and J. M. Pell
Partitioning of IGFBP-5 actions in myogenesis: IGF-independent anti-apoptotic function
J. Cell Sci., May 1, 2004; 117(9): 1737 - 1746.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Castillo, M. Codina, M. L. Martinez, I. Navarro, and J. Gutierrez
Metabolic and mitogenic effects of IGF-I and insulin on muscle cells of rainbow trout
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2004; 286(5): R935 - R941.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Yamada, R. Yanai, M. Nakamura, M. Inui, and T. Nishida
Role of the C Domain of IGFs in Synergistic Promotion, with a Substance P-Derived Peptide, of Rabbit Corneal Epithelial Wound Healing
Invest. Ophthalmol. Vis. Sci., April 1, 2004; 45(4): 1125 - 1131.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. James and J. C. B. M. Zomerdijk
Phosphatidylinositol 3-Kinase and mTOR Signaling Pathways Regulate RNA Polymerase I Transcription in Response to IGF-1 and Nutrients
J. Biol. Chem., March 5, 2004; 279(10): 8911 - 8918.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. A. Conover, L. K. Bale, M. T. Overgaard, E. W. Johnstone, U. H. Laursen, E.-M. Fuchtbauer, C. Oxvig, and J. van Deursen
Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development
Development, March 1, 2004; 131(5): 1187 - 1194.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. Delafontaine, Y.-H. Song, and Y. Li
Expression, Regulation, and Function of IGF-1, IGF-1R, and IGF-1 Binding Proteins in Blood Vessels
Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 435 - 444.
[Abstract] [Full Text]

Home page
 J. Physiol.Home page
M. Hameed, K. H. W. Lange, J. L. Andersen, P. Schjerling, M. Kjaer, S. D. R. Harridge, and G. Goldspink
The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men
J. Physiol., February 15, 2004; 555(1): 231 - 240.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. Colao, D. Ferone, P. Marzullo, and G. Lombardi
Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management
Endocr. Rev., February 1, 2004; 25(1): 102 - 152.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
B Gonzalez-Timon, M Gonzalez-Munoz, C Zaragoza, S Lamas, and E.M Melian
Native and oxidized low density lipoproteins oppositely modulate the effects of insulin-like growth factor I on VSMC
Cardiovasc Res, February 1, 2004; 61(2): 247 - 255.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. C. Sundgren, G. D. Giraud, J. M. Schultz, M. R. Lasarev, P. J. S. Stork, and K. L. Thornburg
Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1481 - R1489.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Herr, O. D. Liang, J. Herrero, U. Lang, K. T. Preissner, V. K. M. Han, and M. Zygmunt
Possible Angiogenic Roles of Insulin-Like Growth Factor II and Its Receptors in Uterine Vascular Adaptation to Pregnancy
J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 4811 - 4817.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. A. Wetterau, M. J. Francis, L. Ma, and P. Cohen
Insulin-Like Growth Factor I Stimulates Telomerase Activity in Prostate Cancer Cells
J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3354 - 3359.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
K. J. Turner, B. S. McIntyre, S. L. Phillips, N. J. Barlow, C. J. Bowman, and P. M. D. Foster
Altered Gene Expression during Rat Wolffian Duct Development in Response to in Utero Exposure to the Antiandrogen Linuron
Toxicol. Sci., July 1, 2003; 74(1): 114 - 128.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
Y. Iwata, Y. Katanosaka, Y. Arai, K. Komamura, K. Miyatake, and M. Shigekawa
A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor-regulated channel
J. Cell Biol., June 9, 2003; 161(5): 957 - 967.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Zaina, L. Pettersson, A. B. Thomsen, C.-M. Chai, Z. Qi, J. Thyberg, and J. Nilsson
Shortened Life Span, Bradycardia, and Hypotension in Mice with Targeted Expression of an Igf2 Transgene in Smooth Muscle Cells
Endocrinology, June 1, 2003; 144(6): 2695 - 2703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. E. Spangenburg, T. Abraha, T. E. Childs, J. S. Pattison, and F. W. Booth
Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent
Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E340 - E350.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. S. Chang, L. Wang, D. Liu, L. Mao, W. K. Hong, F. R. Khuri, and H.-Y. Lee
Correlation between Insulin-like Growth Factor-binding Protein-3 Promoter Methylation and Prognosis of Patients with Stage I Non-Small Cell Lung Cancer
Clin. Cancer Res., December 1, 2002; 8(12): 3669 - 3675.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. Fernandez-Celemin, N. Pasko, V. Blomart, and J.-P. Thissen
Inhibition of muscle insulin-like growth factor I expression by tumor necrosis factor-alpha
Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1279 - E1290.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
W. Kammouni, G. Ramakrishna, G. Sithanandam, G. T. Smith, L. W. Fornwald, A. Masuda, T. Takahashi, and L. M. Anderson
Increased K-Ras Protein and Activity in Mouse and Human Lung Epithelial Cells at Confluence
Cell Growth Differ., September 1, 2002; 13(9): 441 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Castillo, P.-Y. Le Bail, G. Paboeuf, I. Navarro, C. Weil, B. Fauconneau, and J. Gutierrez
IGF-I binding in primary culture of muscle cells of rainbow trout: changes during in vitro development
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R647 - R652.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
H. Yu, F. Jin, X.-O. Shu, B. D. L. Li, Q. Dai, J.-R. Cheng, H. J. Berkel, and W. Zheng
Insulin-like Growth Factors and Breast Cancer Risk in Chinese Women
Cancer Epidemiol. Biomarkers Prev., August 1, 2002; 11(8): 705 - 712.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Fruchtman, D. C. McVey, and R. J. Borski
Characterization of pituitary IGF-I receptors: modulation of prolactin and growth hormone
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R468 - R476.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M.L. Macpherson, R.C.M. Simmen, F.A. Simmen, J. Hernandez, B.R. Sheerin, D.D. Varner, P. Loomis, M.E. Cadario, C.D. Miller, S.P. Brinsko, et al.
Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-2 and -5 in Equine Seminal Plasma: Association with Sperm Characteristics and Fertility
Biol Reprod, August 1, 2002; 67(2): 648 - 654.
[Abstract] [Full Text] [PDF]