Physiol Rev Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Rev. 76: 319-370, 1996;
0031-9333/96 $15.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwab, M. E.
Right arrow Articles by Bartholdi, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwab, M. E.
Right arrow Articles by Bartholdi, D.

Physiological Reviews, Vol 76, 319-370, Copyright © 1996 by American Physiological Society

JOURNAL ARTICLE

Degeneration and regeneration of axons in the lesioned spinal cord

M. E. Schwab and D. Bartholdi
Brain Research Institute, University of Zurich, Switzerland.

For many decades, the inability of lesioned central neurons to regrow was accepted almost as a "law of nature", and on the clinical level, spinal cord and brain lesions were seen as being irreversible. Today we are starting to understand the mechanisms of neuronal regeneration in the central nervous system and its presence in the periphery. There is now a rapid expansion in this field of neuroscience. Developmental neurobiology has produced tools and concepts that start to show their impact on regeneration research. This is particularly true for the availability of antibodies and factors and for the rapidly growing cellular and molecular understanding of crucial aspects of neurite growth, guidance, target finding, and synapse stabilization. New cell biological concepts on the mechanisms of neuron survival and death and on the interaction of inflammatory cells with the central nervous system also find their way into the field of spinal cord and brain lesions and have, indeed, led already to new therapeutic approaches. This review briefly summarizes the current knowledge on the mechanisms involved in degeneration and tissue loss and in axonal regeneration subsequent to spinal cord lesions, particularly in mammals and humans.


This article has been cited by other articles:


Home page
 ICVTSHome page
H. A. Oliveira, M. Ximenes III, F. B. Filho, P. H.C. Carvalho, J. B. GamaFilho, E. R. Parra, V. L. Capelozzi, and J. R. Milanez DeCampos
Experimental selective sympathicotomy (ramicotomy) and sympathetic regeneration
Interactive CardioVascular and Thoracic Surgery, September 1, 2009; 9(3): 411 - 415.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Zou, C. Ho, K. Wong, and M. Tessier-Lavigne
Axotomy-Induced Smad1 Activation Promotes Axonal Growth in Adult Sensory Neurons
J. Neurosci., June 3, 2009; 29(22): 7116 - 7123.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. M. Papadopoulos, S.-Y. Tsai, V. Guillen, J. Ortega, G. L. Kartje, and W. A. Wolf
Motor Recovery and Axonal Plasticity With Short-Term Amphetamine After Stroke
Stroke, January 1, 2009; 40(1): 294 - 302.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
K. K. Park, K. Liu, Y. Hu, P. D. Smith, C. Wang, B. Cai, B. Xu, L. Connolly, I. Kramvis, M. Sahin, et al.
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Science, November 7, 2008; 322(5903): 963 - 966.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
F.-J. Obermair, A. Schroter, and M. Thallmair
Endogenous Neural Progenitor Cells as Therapeutic Target After Spinal Cord Injury
Physiology, October 1, 2008; 23(5): 296 - 304.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
M.-C. Tsai, L.-F. Shen, H.-S. Kuo, H. Cheng, and K.-F. Chak
Involvement of Acidic Fibroblast Growth Factor in Spinal Cord Injury Repair Processes Revealed by a Proteomics Approach
Mol. Cell. Proteomics, September 1, 2008; 7(9): 1668 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. M. Tysseling-Mattiace, V. Sahni, K. L. Niece, D. Birch, C. Czeisler, M. G. Fehlings, S. I. Stupp, and J. A. Kessler
Self-Assembling Nanofibers Inhibit Glial Scar Formation and Promote Axon Elongation after Spinal Cord Injury
J. Neurosci., April 2, 2008; 28(14): 3814 - 3823.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. D. McClellan, M. O. Kovalenko, J. A. Benes, and D. J. Schulz
Spinal Cord Injury Induces Changes in Electrophysiological Properties and Ion Channel Expression of Reticulospinal Neurons in Larval Lamprey
J. Neurosci., January 16, 2008; 28(3): 650 - 659.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
B. K Ormerod, T. D Palmer, and M. A Caldwell
Neurodegeneration and cell replacement
Phil Trans R Soc B, January 12, 2008; 363(1489): 153 - 170.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Ben-Zvi, L. Ben-Gigi, H. Klein, and O. Behar
Modulation of Semaphorin3A Activity by p75 Neurotrophin Receptor Influences Peripheral Axon Patterning
J. Neurosci., November 21, 2007; 27(47): 13000 - 13011.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. S. Boyce, M. Tumolo, I. Fischer, M. Murray, and M. A. Lemay
Neurotrophic Factors Promote and Enhance Locomotor Recovery in Untrained Spinalized Cats
J Neurophysiol, October 1, 2007; 98(4): 1988 - 1996.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
L. H. Shen, Y. Li, J. Chen, Y. Cui, C. Zhang, A. Kapke, M. Lu, S. Savant-Bhonsale, and M. Chopp
One-Year Follow-Up After Bone Marrow Stromal Cell Treatment in Middle-Aged Female Rats With Stroke
Stroke, July 1, 2007; 38(7): 2150 - 2156.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
Z. Su, L. Cao, Y. Zhu, X. Liu, Z. Huang, A. Huang, and C. He
Nogo enhances the adhesion of olfactory ensheathing cells and inhibits their migration
J. Cell Sci., June 1, 2007; 120(11): 1877 - 1887.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Buss, K. Pech, B. A. Kakulas, D. Martin, J. Schoenen, J. Noth, and G. A. Brook
Growth-modulating molecules are associated with invading Schwann cells and not astrocytes in human traumatic spinal cord injury
Brain, April 1, 2007; 130(4): 940 - 953.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Chen, X. Y. Chen, L. B. Jakeman, L. Chen, B. T. Stokes, and J. R. Wolpaw
Operant Conditioning of H-Reflex Can Correct a Locomotor Abnormality after Spinal Cord Injury in Rats
J. Neurosci., November 29, 2006; 26(48): 12537 - 12543.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. W. Barritt, M. Davies, F. Marchand, R. Hartley, J. Grist, P. Yip, S. B. McMahon, and E. J. Bradbury
Chondroitinase ABC Promotes Sprouting of Intact and Injured Spinal Systems after Spinal Cord Injury.
J. Neurosci., October 18, 2006; 26(42): 10856 - 10867.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
I. C Maier and M. E Schwab
Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity
Phil Trans R Soc B, September 29, 2006; 361(1473): 1611 - 1634.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. Vavrek, J. Girgis, W. Tetzlaff, G. W. Hiebert, and K. Fouad
BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats
Brain, June 1, 2006; 129(6): 1534 - 1545.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Dimou, L. Schnell, L. Montani, C. Duncan, M. Simonen, R. Schneider, T. Liebscher, M. Gullo, and M. E. Schwab
Nogo-A-Deficient Mice Reveal Strain-Dependent Differences in Axonal Regeneration
J. Neurosci., May 24, 2006; 26(21): 5591 - 5603.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Cao, Y. Gao, J. B. Bryson, J. Hou, N. Chaudhry, M. Siddiq, J. Martinez, T. Spencer, J. Carmel, R. B. Hart, et al.
The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth.
J. Neurosci., May 17, 2006; 26(20): 5565 - 5573.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
V. Koprivica, K.-S. Cho, J. B. Park, G. Yiu, J. Atwal, B. Gore, J. A. Kim, E. Lin, M. Tessier-Lavigne, D. F. Chen, et al.
EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans
Science, October 7, 2005; 310(5745): 106 - 110.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. M. Schwab, P. P. Monnier, H. J. Schluesener, S. Conrad, R. Beschorner, L. Chen, R. Meyermann, and B. K. Mueller
Central Nervous System Injury-Induced Repulsive Guidance Molecule Expression in the Adult Human Brain
Arch Neurol, October 1, 2005; 62(10): 1561 - 1568.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
D. P. Stirling, K. M. Koochesfahani, J. D. Steeves, and W. Tetzlaff
Minocycline as a Neuroprotective Agent
Neuroscientist, August 1, 2005; 11(4): 308 - 322.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
Y. Chen, X. Y. Chen, L. B. Jakeman, G. Schalk, B. T. Stokes, and J. R. Wolpaw
The Interaction of a New Motor Skill and an Old One: H-Reflex Conditioning and Locomotion in Rats
J. Neurosci., July 20, 2005; 25(29): 6898 - 6906.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
M. L. McEwen and J. E. Springer
A Mapping Study of Caspase-3 Activation Following Acute Spinal Cord Contusion in Rats
J. Histochem. Cytochem., July 1, 2005; 53(7): 809 - 819.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Brunelli, P. Spano, S. Barlati, B. Guarneri, A. Barbon, R. Bresciani, and M. Pizzi
Glutamatergic reinnervation through peripheral nerve graft dictates assembly of glutamatergic synapses at rat skeletal muscle
PNAS, June 14, 2005; 102(24): 8752 - 8757.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Fouad, L. Schnell, M. B. Bunge, M. E. Schwab, T. Liebscher, and D. D. Pearse
Combining Schwann Cell Bridges and Olfactory-Ensheathing Glia Grafts with Chondroitinase Promotes Locomotor Recovery after Complete Transection of the Spinal Cord
J. Neurosci., February 2, 2005; 25(5): 1169 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Buss, K. Pech, D. Merkler, B. A. Kakulas, D. Martin, J. Schoenen, J. Noth, M. E. Schwab, and G. A. Brook
Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cord
Brain, February 1, 2005; 128(2): 356 - 364.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
G. Serini and F. Bussolino
Common Cues in Vascular and Axon Guidance
Physiology, December 1, 2004; 19(6): 348 - 354.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. B. Reece, D. O. Okonkwo, P. I. Ellman, P. S. Warren, R. L. Smith, A. S. Hawkins, J. Linden, I. L. Kron, C. G. Tribble, and J. A. Kern
The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation
J. Thorac. Cardiovasc. Surg., December 1, 2004; 128(6): 925 - 932.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
V. Dietz and R. Muller
Degradation of neuronal function following a spinal cord injury: mechanisms and countermeasures
Brain, October 1, 2004; 127(10): 2221 - 2231.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Lu, H. Yang, L. L. Jones, M. T. Filbin, and M. H. Tuszynski
Combinatorial Therapy with Neurotrophins and cAMP Promotes Axonal Regeneration beyond Sites of Spinal Cord Injury
J. Neurosci., July 14, 2004; 24(28): 6402 - 6409.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Nikulina, J. L. Tidwell, H. N. Dai, B. S. Bregman, and M. T. Filbin
The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery
PNAS, June 8, 2004; 101(23): 8786 - 8790.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. J. Hutchinson, F. Gomez-Pinilla, M. J. Crowe, Z. Ying, and D. M. Basso
Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats
Brain, June 1, 2004; 127(6): 1403 - 1414.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Dietz and S. J. Harkema
Locomotor activity in spinal cord-injured persons
J Appl Physiol, May 1, 2004; 96(5): 1954 - 1960.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Buss, G. A. Brook, B. Kakulas, D. Martin, R. Franzen, J. Schoenen, J. Noth, and A. B. Schmitt
Gradual loss of myelin and formation of an astrocytic scar during Wallerian degeneration in the human spinal cord
Brain, January 1, 2004; 127(1): 34 - 44.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Moreau-Fauvarque, A. Kumanogoh, E. Camand, C. Jaillard, G. Barbin, I. Boquet, C. Love, E. Y. Jones, H. Kikutani, C. Lubetzki, et al.
The Transmembrane Semaphorin Sema4D/CD100, an Inhibitor of Axonal Growth, Is Expressed on Oligodendrocytes and Upregulated after CNS Lesion
J. Neurosci., October 8, 2003; 23(27): 9229 - 9239.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. M. Jensen and R. Shi
Effects of 4-Aminopyridine on Stretched Mammalian Spinal Cord: The Role of Potassium Channels in Axonal Conduction
J Neurophysiol, October 1, 2003; 90(4): 2334 - 2340.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Bouslama-Oueghlani, R. Wehrle, C. Sotelo, and I. Dusart
The Developmental Loss of the Ability of Purkinje Cells to Regenerate Their Axons Occurs in the Absence of Myelin: An In Vitro Model to Prevent Myelination
J. Neurosci., September 10, 2003; 23(23): 8318 - 8329.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
S. J. Zottoli and M. M. Freemer
Recovery of C-starts, equilibrium and targeted feeding after whole spinal cord crush in the adult goldfish Carassius auratus
J. Exp. Biol., September 1, 2003; 206(17): 3015 - 3029.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Q. Bundesen, T. A. Scheel, B. S. Bregman, and L. F. Kromer
Ephrin-B2 and EphB2 Regulation of Astrocyte-Meningeal Fibroblast Interactions in Response to Spinal Cord Lesions in Adult Rats
J. Neurosci., August 27, 2003; 23(21): 7789 - 7800.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. J. Ruitenberg, G. W. Plant, F. P. T. Hamers, J. Wortel, B. Blits, P. A. Dijkhuizen, W. H. Gispen, G. J. Boer, and J. Verhaagen
Ex Vivo Adenoviral Vector-Mediated Neurotrophin Gene Transfer to Olfactory Ensheathing Glia: Effects on Rubrospinal Tract Regeneration, Lesion Size, and Functional Recovery after Implantation in the Injured Rat Spinal Cord
J. Neurosci., August 6, 2003; 23(18): 7045 - 7058.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Oertle, M. E. van der Haar, C. E. Bandtlow, A. Robeva, P. Burfeind, A. Buss, A. B. Huber, M. Simonen, L. Schnell, C. Brosamle, et al.
Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions
J. Neurosci., July 2, 2003; 23(13): 5393 - 5406.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
T. OERTLE, M. KLINGER, C. A. O. STUERMER, and M. E. SCHWAB
A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family
FASEB J, July 1, 2003; 17(10): 1238 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. L. Goldberg
How does an axon grow?
Genes & Dev., April 15, 2003; 17(8): 941 - 958.
[Full Text] [PDF]

Home page
 Inj. Prev.Home page
C H Tator
Strategies for recovery and regeneration after brain and spinal cord injury
Inj. Prev., December 1, 2002; 8(90004): iv33 - 36.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
F. M. Bareyre, B. Haudenschild, and M. E. Schwab
Long-Lasting Sprouting and Gene Expression Changes Induced by the Monoclonal Antibody IN-1 in the Adult Spinal Cord
J. Neurosci., August 15, 2002; 22(16): 7097 - 7110.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. H. Nash, R. C. Borke, and J. J. Anders
Ensheathing Cells and Methylprednisolone Promote Axonal Regeneration and Functional Recovery in the Lesioned Adult Rat Spinal Cord
J. Neurosci., August 15, 2002; 22(16): 7111 - 7120.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
B. Calancie, M. R. Molano, and J. G. Broton
Interlimb reflexes and synaptic plasticity become evident months after human spinal cord injury
Brain, May 1, 2002; 125(5): 1150 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. B. Huber, O. Weinmann, C. Brosamle, T. Oertle, and M. E. Schwab
Patterns of Nogo mRNA and Protein Expression in the Developing and Adult Rat and After CNS Lesions
J. Neurosci., May 1, 2002; 22(9): 3553 - 3567.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. E. Schwab
Repairing the Injured Spinal Cord
Science, February 8, 2002; 295(5557): 1029 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Hauben, A. Ibarra, T. Mizrahi, R. Barouch, E. Agranov, and M. Schwartz
Vaccination with a Nogo-A-derived peptide after incomplete spinal-cord injury promotes recovery via a T-cell-mediated neuroprotective response: Comparison with other myelin antigens
PNAS, December 18, 2001; 98(26): 15173 - 15178.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Ichijo and I. Kawabata
Roles of the Telencephalic Cells and their Chondroitin Sulfate Proteoglycans in Delimiting an Anterior Border of the Retinal Pathway
J. Neurosci., December 1, 2001; 21(23): 9304 - 9314.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. I. Romero, N. Rangappa, M. G. Garry, and G. M. Smith
Functional Regeneration of Chronically Injured Sensory Afferents into Adult Spinal Cord after Neurotrophin Gene Therapy
J. Neurosci., November 1, 2001; 21(21): 8408 - 8416.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
M. B. Bunge
Book Review: Bridging Areas of Injury in the Spinal Cord
Neuroscientist, August 1, 2001; 7(4): 325 - 339.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
D. Cai, J. Qiu, Z. Cao, M. McAtee, B. S. Bregman, and M. T. Filbin
Neuronal Cyclic AMP Controls the Developmental Loss in Ability of Axons to Regenerate
J. Neurosci., July 1, 2001; 21(13): 4731 - 4739.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. M. McTigue, P. Wei, and B. T. Stokes
Proliferation of NG2-Positive Cells and Altered Oligodendrocyte Numbers in the Contused Rat Spinal Cord
J. Neurosci., May 15, 2001; 21(10): 3392 - 3400.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Weidner, A. Ner, N. Salimi, and M. H. Tuszynski
Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury
PNAS, March 13, 2001; 98(6): 3513 - 3518.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Brosamle, A. B. Huber, M. Fiedler, A. Skerra, and M. E. Schwab
Regeneration of Lesioned Corticospinal Tract Fibers in the Adult Rat Induced by a Recombinant, Humanized IN-1 Antibody Fragment
J. Neurosci., November 1, 2000; 20(21): 8061 - 8068.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Hauben, O. Butovsky, U. Nevo, E. Yoles, G. Moalem, E. Agranov, F. Mor, R. Leibowitz-Amit, E. Pevsner, S. Akselrod, et al.
Passive or Active Immunization with Myelin Basic Protein Promotes Recovery from Spinal Cord Contusion
J. Neurosci., September 1, 2000; 20(17): 6421 - 6430.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. J. Z'Graggen, K. Fouad, O. Raineteau, G. A. S. Metz, M. E. Schwab, and G. L. Kartje
Compensatory Sprouting and Impulse Rerouting after Unilateral Pyramidal Tract Lesion in Neonatal Rats
J. Neurosci., September 1, 2000; 20(17): 6561 - 6569.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
D M. Basso
Neuroanatomical Substrates of Functional Recovery After Experimental Spinal Cord Injury: Implications of Basic Science Research for Human Spinal Cord Injury
Physical Therapy, August 1, 2000; 80(8): 808 - 817.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. I. Romero, N. Rangappa, L. Li, E. Lightfoot, M. G. Garry, and G. M. Smith
Extensive Sprouting of Sensory Afferents and Hyperalgesia Induced by Conditional Expression of Nerve Growth Factor in the Adult Spinal Cord
J. Neurosci., June 15, 2000; 20(12): 4435 - 4445.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
G. D. Bittner, T. Schallert, and J. D. Peduzzi
Degeneration, Trophic Interactions, and Repair of Severed Axons: A Reconsideration of Some Common Assumptions
Neuroscientist, April 1, 2000; 6(2): 88 - 109.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
T W Ford, C W Vaughan, and P A Kirkwood
Changes in the distribution of synaptic potentials from bulbospinal neurones following axotomy in cat thoracic spinal cord
J. Physiol., April 1, 2000; 524(1): 163 - 178.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Buffo, M. Zagrebelsky, A. B. Huber, A. Skerra, M. E. Schwab, P. Strata, and F. Rossi
Application of Neutralizing Antibodies against NI-35/250 Myelin-Associated Neurite Growth Inhibitory Proteins to the Adult Rat Cerebellum Induces Sprouting of Uninjured Purkinje Cell Axons
J. Neurosci., March 15, 2000; 20(6): 2275 - 2286.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M Schmalfeldt, C. Bandtlow, M. Dours-Zimmermann, K. Winterhalter, and D. Zimmermann
Brain derived versican V2 is a potent inhibitor of axonal growth
J. Cell Sci., January 3, 2000; 113(5): 807 - 816.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
B. P. Niederost, D. R. Zimmermann, M. E. Schwab, and C. E. Bandtlow
Bovine CNS Myelin Contains Neurite Growth-Inhibitory Activity Associated with Chondroitin Sulfate Proteoglycans
J. Neurosci., October 15, 1999; 19(20): 8979 - 8989.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Liu, D. Kim, B. T. Himes, S. Y. Chow, T. Schallert, M. Murray, A. Tessler, and I. Fischer
Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function
J. Neurosci., June 1, 1999; 19(11): 4370 - 4387.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
R. D. Fields, M. E. Schwab, and J. Silver
Does CNS Myelin Inhibit Axon Regeneration?
Neuroscientist, January 1, 1999; 5(1): 12 - 18.
[Abstract] [PDF]

Home page
 PhysiologyHome page
M. E. Schwab
Regenerative Nerve Fiber Growth in the Adult Central Nervous System
Physiology, December 1, 1998; 13(6): 294 - 298.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Zagrebelsky, A. Buffo, A. Skerra, M. E. Schwab, P. Strata, and F. Rossi
Retrograde Regulation of Growth-Associated Gene Expression in Adult Rat Purkinje Cells by Myelin-Associated Neurite Growth Inhibitory Proteins
J. Neurosci., October 1, 1998; 18(19): 7912 - 7929.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H. Song, G. Ming, Z. He, M. Lehmann, L. McKerracher, M. Tessier-Lavigne, and M. Poo
Conversion of Neuronal Growth Cone Responses from Repulsion to Attraction by Cyclic Nucleotides
Science, September 4, 1998; 281(5382): 1515 - 1518.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. A. Spillmann, C. E. Bandtlow, F. Lottspeich, F. Keller, and M. E. Schwab
Identification and Characterization of a Bovine Neurite Growth Inhibitor (bNI-220)
J. Biol. Chem., July 24, 1998; 273(30): 19283 - 19293.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. J. Z'Graggen, G. A. S. Metz, G. L. Kartje, M. Thallmair, and M. E. Schwab
Functional Recovery and Enhanced Corticofugal Plasticity after Unilateral Pyramidal Tract Lesion and Blockade of Myelin-Associated Neurite Growth Inhibitors in Adult Rats
J. Neurosci., June 15, 1998; 18(12): 4744 - 4757.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. S. Diener and B. S. Bregman
Fetal Spinal Cord Transplants Support Growth of Supraspinal and Segmental Projections after Cervical Spinal Cord Hemisection in the Neonatal Rat
J. Neurosci., January 15, 1998; 18(2): 779 - 793.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. R. Saunders, P. Kitchener, G. W. Knott, J. G. Nicholls, A. Potter, and T. J. Smith
Development of Walking, Swimming and Neuronal Connections after Complete Spinal Cord Transection in the Neonatal Opossum, Monodelphis domestica
J. Neurosci., January 1, 1998; 18(1): 339 - 355.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Buffo, A. J. D. G. Holtmaat, T. Savio, J. S. Verbeek, J. Oberdick, A. B. Oestreicher, W. H. Gispen, J. Verhaagen, F. Rossi, and P. Strata
Targeted Overexpression of the Neurite Growth-Associated Protein B-50/GAP-43 in Cerebellar Purkinje Cells Induces Sprouting after Axotomy But Not Axon Regeneration into Growth-Permissive Transplants
J. Neurosci., November 15, 1997; 17(22): 8778 - 8791.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. Dusart, M. S. Airaksinen, and C. Sotelo
Purkinje Cell Survival and Axonal Regeneration Are Age Dependent: An In Vitro Study
J. Neurosci., May 15, 1997; 17(10): 3710 - 3726.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online