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Physiol. Rev. 75: 519-560, 1995;
0031-9333/95 $15.00
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Physiological Reviews, Vol 75, 519-560, Copyright © 1995 by American Physiological Society

JOURNAL ARTICLE

Flow-mediated endothelial mechanotransduction

P. F. Davies
Department of Pathology, Pritzker School of Medicine, University of Chicago, Illinois, USA.

Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodeling, and the localization of atherosclerotic lesions. Major regulation of the blood vessel responses occurs by the action of hemodynamic shear stresses on the endothelium. The transmission of hemodynamic forces throughout the endothelium and the mechanotransduction mechanisms that lead to biophysical, biochemical, and gene regulatory responses of endothelial cells to hemodynamic shear stresses are reviewed.


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N. B. Wood, S. Z. Zhao, A. Zambanini, M. Jackson, W. Gedroyc, S. A. Thom, A. D. Hughes, and X. Y. Xu
Curvature and tortuosity of the superficial femoral artery: a possible risk factor for peripheral arterial disease
J Appl Physiol, November 1, 2006; 101(5): 1412 - 1418.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
M. Chachisvilis, Y.-L. Zhang, and J. A. Frangos
G protein-coupled receptors sense fluid shear stress in endothelial cells
PNAS, October 17, 2006; 103(42): 15463 - 15468.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
K. Lawler, E. Foran, G. O'Sullivan, A. Long, and D. Kenny
Mobility and invasiveness of metastatic esophageal cancer are potentiated by shear stress in a ROCK- and Ras-dependent manner
Am J Physiol Cell Physiol, October 1, 2006; 291(4): C668 - C677.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
C. Friedrich, N. Endlich, W. Kriz, and K. Endlich
Podocytes are sensitive to fluid shear stress in vitro
Am J Physiol Renal Physiol, October 1, 2006; 291(4): F856 - F865.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
I. Eitenmuller, O. Volger, A. Kluge, K. Troidl, M. Barancik, W.-J. Cai, M. Heil, F. Pipp, S. Fischer, A. J.G. Horrevoets, et al.
The Range of Adaptation by Collateral Vessels After Femoral Artery Occlusion
Circ. Res., September 15, 2006; 99(6): 656 - 662.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
T. Moriguchi, M. Hamada, N. Morito, T. Terunuma, K. Hasegawa, C. Zhang, T. Yokomizo, R. Esaki, E. Kuroda, K. Yoh, et al.
MafB Is Essential for Renal Development and F4/80 Expression in Macrophages
Mol. Cell. Biol., August 1, 2006; 26(15): 5715 - 5727.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
A. Lichtenberg, I. Tudorache, S. Cebotari, M. Suprunov, G. Tudorache, H. Goerler, J.-K. Park, D. Hilfiker-Kleiner, S. Ringes-Lichtenberg, M. Karck, et al.
Preclinical Testing of Tissue-Engineered Heart Valves Re-Endothelialized Under Simulated Physiological Conditions
Circulation, July 4, 2006; 114(1_suppl): I-559 - I-565.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. Nakatsuka, T. Sokabe, K. Yamamoto, Y. Sato, K. Hatakeyama, A. Kamiya, and J. Ando
Shear stress induces hepatocyte PAI-1 gene expression through cooperative Sp1/Ets-1 activation of transcription
Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G26 - G34.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. H. Ali, P. T. Mungai, and P. T. Schumacker
Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants
Am J Physiol Lung Cell Mol Physiol, July 1, 2006; 291(1): L38 - L45.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
Y. Richter and E. R. Edelman
Cardiology Is Flow
Circulation, June 13, 2006; 113(23): 2679 - 2682.
[Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Hong, D. Jaron, D. G. Buerk, and K. A. Barbee
Heterogeneous response of microvascular endothelial cells to shear stress
Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2498 - H2508.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
R. Kelly, T. Ruane-O'Hora, M. I. M. Noble, A. J. Drake-Holland, and H. M. Snow
Differential inhibition by hyperglycaemia of shear stress- but not acetylcholine-mediated dilatation in the iliac artery of the anaesthetized pig
J. Physiol., May 15, 2006; 573(1): 133 - 145.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
N. I. Gokina and T. Goecks
Upregulation of endothelial cell Ca2+ signaling contributes to pregnancy-enhanced vasodilation of rat uteroplacental arteries
Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H2124 - H2135.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
Y. Fang, E. R. Mohler III, E. Hsieh, H. Osman, S. M. Hashemi, P. F. Davies, G. H. Rothblat, R. L. Wilensky, and I. Levitan
Hypercholesterolemia Suppresses Inwardly Rectifying K+ Channels in Aortic Endothelium In Vitro and In Vivo
Circ. Res., April 28, 2006; 98(8): 1064 - 1071.
[Abstract] [Full Text] [PDF]

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 Ann. Thorac. Surg.Home page
T. S. Maxey, L. G. Fernandez, T. B. Reece, W. B. Keeling, I. L. Kron, and V. E. Laubach
Endothelial Nitric Oxide Synthase is Essential for Postpneumonectomy Compensatory Vasodilation
Ann. Thorac. Surg., April 1, 2006; 81(4): 1234 - 1238.
[Abstract] [Full Text] [PDF]

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 Physiol. Rev.Home page
A. Tedgui and Z. Mallat
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Physiol Rev, April 1, 2006; 86(2): 515 - 581.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
S. M. Nauli, S. Rossetti, R. J. Kolb, F. J. Alenghat, M. B. Consugar, P. C. Harris, D. E. Ingber, M. Loghman-Adham, and J. Zhou
Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction
J. Am. Soc. Nephrol., April 1, 2006; 17(4): 1015 - 1025.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
L. H. Romer, K. G. Birukov, and J. G.N. Garcia
Focal Adhesions: Paradigm for a Signaling Nexus
Circ. Res., March 17, 2006; 98(5): 606 - 616.
[Abstract] [Full Text] [PDF]


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