TABLE 4.   Shared biological activities of IL-1, IL-6, and TNF- Immunologic propertiesT-cell activationB-cell activationNonspecific resistance to infection Neuroendocrine actionsActivation of the hypothalamic-pituitary-adrenal axisSuppression of the hypothalamic-pituitary-gonadal axisSuppression of the hypothalamic-pituitary-thyroidal axis CNS activitiesFeverHypermetabolismAnorexia Effects on liverAcute phase protein synthesis CNS, central nervous system.